Bioprocessing application notebookPurification of biomolecules
The purification and recovery of a biological target molecule out of a tissue, cell or fermentation broth - the so called downstream processing (DSP) - usually requires a combination of separation technologies. Bioprocess chromatography is the most important technique for this purpose.
Today, biopharmaceuticals are the fastest growing product segment of the pharmaceutical industry. An effective and affordable purification of therapeutic biomolecules is key for the successful development and commercialization of new drugs, no matter whether biologic, biosimilar, or biobetter. With new biopharmaceutical formats, such as bispecific mAbs, antibody fragments and antibody-drug-conjugates (ADCs) in the pipeline, rapid development of DSP steps will become even more important.
Toyopearl®, TSKgel®, and Ca++Pure-HA® process media are renowned for their quality, reliability, and productivity, and cover all modes of bioprocess chromatography, including affinity (AFC), ion exchange