News items October 2020

Creative Biostructure, a biotechnology company that provides contract services to both academia and industries in the field of structural biology, now provides Plasmid Design and Construction platform to rapidly and reliably deliver application-specialized plasmids. Plasmids are intrinsically tiny, self-contained genomes that can replicate independently and often do not adversely affect host cells. Therefore, they are very useful tools for manipulating genes. Creative Biostructure is proud to provide various customized plasmid vector construction services, including constitutive and inducible vectors for various expression systems (bacteria, yeast, mammals, and insects). Creative Biostructure can also help you if your desired plasmid vector is not available. The company has developed an advanced gene synthesis platform for modular construction of plasmid vectors. Some modules have segments that are easily interchangeable, encoding not only regulatory and functional

Matexcel, a company that specialized in providing materials and services for worldwide researchers in academia and industry, recently announced the release of a series of collagen products that can be used for tissue-culture, gel, drug delivery, skin replacement, and bone substitutes and so on. Collagen is the most abundant protein in mammals, accounting for 25% to 30% of the total protein. It is widely present in all tissues from the body surface of lower vertebrates to the mammalian body. The collagen monomer is a long cylindrical protein with a length of about 280 nm and a diameter of 1.4~1.5 nm. It consists of three polypeptide chains entwined in a super-coiled form. Collagen is composed of a group of proteins with slightly different structures. 27 different types of collagen have been found. According to the order of discovery, they are divided into type I collagen, type II collagen, and type IM collagen. The most common type is type I collagen. Collagen is a

As a prominent plant biotechnology company, Lifeasible now provides flow cytometry services in the field of plant biology as an efficient method for quantitative cell measurement with reduced cost. Flow cytometry is a widely used laser-based biophysical technique for cell counting, cell properties measurement and biomarker detection. The standard flow cytometer system consists of fluidic, optical and electronic components. During the assay, suspended cells traverse a laser beam one at a time and the parameters of the cells are detected and measured by light scattering. When connected to a sorting device, it can also physically separate cells and biological particles. Flow cytometry techniques were originally developed in animal systems. Flow cytometry assays were first used in plants four decades ago. Over the years, flow cytometry has gained wide application in the field of plant biology as a low-cost, effective method for quantitative cell measurements. So far, flow

Profacgen, with an organized team of scientists with extensive experience in the study of protein-protein interaction, recently updated its pull down assay service to help efficiently and specifically verify the predicted protein-protein interactions or identify novel interactions. Protein-protein interactions (PPIs) are established when protein molecules physically contact each other through hydrogen or hydrophobic bonds, van der Waals forces, ionic forces, or even covalent bonds. This phenomenon underlies a wide range of fundamental cellular events, such as signal transduction, molecular transport and various metabolic pathways. PPIs also underlie many diseases. Therefore, PPIs have been extensively studied in the field of bioscience and medical research. Protein pull-down assay is an in vitro affinity purification method that uses bait proteins to enrich proteins that interact with bait proteins. It can be used to confirm existing protein-protein interactions found

Sieve shaker S 12 Vibrotechnik The Sieve Shakers are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics S 12 Sieve diameter -120 (mm) Maximum number of sieves - 10 Type of vibration drive: VD 30, VD 30T, EVD Amplitude of vibrations (depending on weight of sample and number of sieves) - 0,25-0,75 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220 (V) Maximum overall dimensions: Length - 390 (mm) Width - 350 (mm) Height - 684 (mm) Maximum weight - 23 (kg)

Sieve Shaker S 20 — Vibrotechnik The Sieve Shaker S 20 are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics S 20 Sieve diameter -200  (mm)        Maximum number of sieves - 8 Amplitude of vibrations (depending on weight of sample and number of sieves) - 0,25-0,75 (mm)     Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220 (V)   Maximum overall dimensions:                Length - 390 (mm) Width - 350 (mm) Height - 760 (mm) Maximum weight - 26 (kg)       

Sieve Shaker S 30 — Vibrotechnik The Sieve Shaker S 30 are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics S 30 Sieve diameter -300  (mm)        Maximum number of sieves - 6 Amplitude of vibrations (depending on weight of sample and number of sieves) - 0,25-0,75 (mm)     Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220 (V)   Maximum overall dimensions:               Length - 390 (mm) Width - 350 (mm) Height - 650 (mm) Maximum weight - 28 (kg)     

Sieve Shaker S 40 — Vibrotechnik The Sieve Shaker S 40 are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics S 40 Sieve diameter -400  (mm)        Maximum number of sieves - 10 Type of vibration drive: VD 50 Amplitude of vibrations (depending on weight of sample and number of sieves) - 2-4 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220/380 (V)        Maximum overall dimensions:                Length - 576 (mm) Width - 576 (mm) Height -  1236 (mm) Maximum weight - 136 (kg)      

Sieve Shaker S 50 — Vibrotechnik The Sieve Shaker S 50 are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics S 50 Sieve diameter - 500  (mm)       Maximum number of sieves - 8 Type of vibration drive: VD 50 Amplitude of vibrations (depending on weight of sample and number of sieves) - 2-4 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220/380 (V)        Maximum overall dimensions:                Length - 560 (mm) Width -  550 (mm) Height - 1100 (mm) Maximum weight - 101(kg)       

Sieve Shaker S 20x4 (on base VD 50) - Vibrotechnik The Sieve Shaker S 20x4 (on base VD 50) are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics S 20x4 Sieve diameter - 200  (mm)       Maximum number of sieves - 4x10 Type of vibration drive: VP 50 Amplitude of vibrations (depending on weight of sample and number of sieves) - 2-4 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220/380 (V)        Maximum overall dimensions:                Length - 560 (mm) Width - 550 (mm) Height - 1000 (mm) Maximum weight - 100(kg)       

Sieve Shaker S 30 (on base VD 50) - Vibrotechnik The Sieve Shaker S 30 (on base VD 50) are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics S 30 (on base VD 50) Sieve diameter - 300  (mm)       Maximum number of sieves - 12 Type of vibration drive: VD 50 Amplitude of vibrations (depending on weight of sample and number of sieves) - 2-4 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220/380 (V)        Maximum overall dimensions:                Length - 565 (mm) Width - 550 (mm) Height - 1155 (mm) Maximum weight - 82(kg)         

CD Genomics, a leader in sequencing, microarray analysis, library construction and genotyping, recently announced availability of its CDAMP® SARS-CoV-2 Panel Kit, CDCAP® β-CoVs Panel Kit and CDCAP® Respiratory Virus Panel Kit for SARS-CoV-2 detection and research via its predesigend NGS panels. The highly multiplexed target enrichment kit covers the entire genome of the SARS-CoV-2 virus that is the cause of the global COVID-19 pandemic, enabling complete genome sequencing and epidemiological studies of this dangerous new pathogen. The novel Coronavirus pandemic has gathered a quick response from the viral research and therapeutics community around the world. The researchers need robust and reliable genomic tools to classify and characterize viral samples, and genome engineering tools to build effective vaccines to help stop the spread of this virus. CD Genomics chief scientist commented, “It is important for researchers to learn more about the SARS-CoV-2 virus,

As an excellent supplier and manufacturer, Creative Enzymes has recently released enzymes for chemical processing to satisfy the demands of researchers in chemical industry. With more than ten years of experience in offering professional services and high-quality products for academic use and pharmaceutical industries, Creative Enzymes is able to offer remarkable enzyme products for biochemists. The chemical industry represents one of the biggest economic sectors worldwide and American companies play a dominant role. The American chemical industry is highly-developed, but the introduction of new technologies continues. The impact of enzymes as catalysts in the chemical industry enzyme applications, which are in different development stages, are found mainly in the organics, drugs, and cleaners segments. “As a sustainable catalyst with high reaction rate, enzymes have attracted more attention beyond chemical catalysts. Nowadays, more and more chemical processes are

Non-Glass: Hydrogen Ion Activity instead of H+ Concentration ISFET Sensors Versus Glass Bulb pH Electrodes The method by which ISFET sensors and glass bulb pH electrodes achieve a response is significantly different. In buffers and most samples, the pH value based on both technologies will be the same. However, differences due to method may occur in applications like milk and cheese. As these are reproducible readings, the bias can be set in the pH meters to come to the same readings as the glass electrodes. The reason for different outcomes is primarily the following. Glass bulb electrodes use a permeable glass membrane involving an ion exchange process. The pH value measured by glass electrodes is based on the hydrogen ion (H+) concentration. Instead, ISFET sensors use an instantaneous surface reaction. The pH value measured by ISFET electrodes is based on the H+ activity as described below. What Is pH? The pH is a widely used way of expressing the acidity or alkalinity of aqueous solutions. In essence it is a means of indicating

Aiming to build a bridge between academics and industry, Protheragen, a company founded in Ronkonkoma, New York, 2009, announces to offer license opportunities for drug R&D companies. Protheragen is previously known for three businesses, including: intermediary service, project incubation, and equity investment. For pharmaceutical companies, the seeking of high-quality novel drug research and development programs is not always easy. “Fully aware of how hard it is to successfully develop a new drug, we decide to provide free access to licensing opportunities concerning drug development programs,” says the Marketing Chief of Protheragen. “We aspire to play a role in transforming the scientific innovations into medications, helping patients with the most challenging diseases.” The majority projects that are ready to be licensed are focused on oncology, and many of them are at preclinical stage with great therapeutic and market potential. In terms of different treatment

for Drug Discovery On October 24, 2020, AI & Medicine, one of the forerunners in the AI-assisted medicine area, announces it now provides PK/PD modeling service to help scientists and researchers more efficiently screen drugs and thus accelerating the process of new drug development. The company is known as an expert in applying artificial intelligence into drug discovery, personalized healthcare and various other medical applications. PK/PD modeling is a mathematical technique used to predict the effect and efficacy of drug dosing over time. “More specifically, pharmacokinetic models describe how the body reacts to a drug in terms of absorption, distribution, metabolism, and excretion. Pharmacodynamic models describe how a drug affects the body by linking the drug concentration to an efficacy (or safety) metric. A well-characterized PK/PD model is an important tool in guiding the design of experiments and trials,” commented a senior expert from AI & Medicine. With the progress of pharmacokinetic

AI & Medicine The broad prospects of artificial intelligence (AI) have led many pharmaceutical companies to incorporate it into their strategic focus. Especially considering the current high R&D investment and long R&D cycle, even a slight improvement to the status quo is sufficient to prove that AI is actually helpful in drug development. Similarly, the increasingly important post-marketing patient support and rational drug use tracking will further promote the application of AI in the medical industry. At the same time, as the technology itself continues to evolve, AI companies are also continuing to improve their products to meet the different needs of pharmaceutical customers. Driven by the above factors, it can be foreseen that in the next ten years, AI technology will flourish in the field of biological sciences (especially drug discovery). The development of AI technology will significantly change the way pharmaceutical companies operate and replace some traditional time-consuming

from Molecular Research to Large-Scale Population Modeling Projects that apply deep learning (DL) to cancer treatment can not only advance cancer research and treatment, but also improve the capabilities and infrastructure of deep learning, and ultimately accelerate the research of exascale computers (capable of a billion billion calculations per second). The advancement of biomedicine and the rise of the next generation of leading computers (exascale Development) will definitely promote the development of cancer treatment. Among them, the rapid development of deep learning and data-driven science should be credited. The Joint Design of Advanced Computing Solutions for Cancer (JDACS4C) program was created in 2016 to accelerate cancer research using emerging exascale computing capabilities. Three JDACS4C pilot projects, including many studies from the molecular level to population size, are to support the CANcer Distributed Learning Environment project. These works aim to gain insights into scalable machine learning tools, reduce

for Material, Medicinal, Agricultural, Organic Chemistry Research The benefits of fluorochemistry to pharmaceutical applications are obvious and the past decades has seen increasing synthesis of fluorinated compounds in the preparation of new pharmaceuticals and agrochemicals. To better meet the growing needs of customers worldwide, the New York-based chemical supplier Alfa Chemistry announced to offer high-purity fluorinated building blocks for various application scenarios such as material, medicine, agriculture and organic chemistry. Fluorinated building blocks are compounds containing negatively charged fluorine, and are usually used for preparing compounds. “In recent years, the preparations and the applications of fluorinated compounds have aroused widespread interest among scientists. Researchers have explored the possible benefits they could bring about to fields like material chemistry, medicinal chemistry, organic chemistry and biochemistry,” says a senior scientist from Alfa Chemistry. At Alfa Chemistry, the two major

On October 22, 2020, the US-based company Alfa Chemistry announced to provide varieties of analytical standard reagents for the analysis and detection of chromatography (HPLC, GPC, GC), electrophoresis, microscopy, spectrophotometry, titration, and physical property testing. The products newly added cover life science standards, agricultural and environmental standards, clinical application standards, air testing standards, certification standards, food and beverage standards, cosmetics testing standards, organic standard solutions, etc. Meanwhile, Alfa Chemistry also offers custom-tailored analytical testing services that can help clients solve problems case by case. An analytical standard is a compound of suitable purity and known concentration and is often used as a calibration standard for an assay for the following purposes: to confirm the presence of specific components in mixtures; to increase the precision of quantitative analysis; to perform a test or a calibration

Fuels Drug R&D Alfa Chemistry has a cGMP-compliant laboratory that can provide high-quality pharmaceutical analytical services at every stage of drug development. With constantly updated analytical methods and equipment and also the ability to adapt to changing regulations and ongoing needs, the lab helps customers to specify and solve the difficulties and problems that may exist in drug R&D so as to achieve the final success. Effectiveness and safety are the top concerns in developing pharmaceutical products. During the research and production process, lots of factors are playing a role in deciding the final results, for example, the physical and chemical properties, the impurities introduced in the production process, and even the storage container of the pharmaceutical. “Having realized the significance of pharmaceutical analytical testing, some pharmaceutical companies come to us and seek for customized pharmaceutical analytical services including Biopharmaceutical Characterization,

for Diverse Applications On October 23, 2020, Alfa Chemistry Catalysts, a specialized sub-brand of Alfa Chemistry, announced the release of bulk catalysts, which could be extensively used in industries like automotive, battery manufacturing, fuel cells, hydrogen storage, oil & gas, solar energy, water treatment, etc. Catalysts typically speed up a reaction by reducing the activation energy or changing the reaction mechanism. “Common types of catalysts include enzymes, acid-base catalysts, and heterogeneous catalysts. Here at Alfa Chemistry, customers can easily find the exact catalysts they need from our varieties of collections,” explains a senior scientist from Alfa Chemistry Catalysts. Catalysts find application across all industry segments, such as refinery, petrochemicals, chemicals, and foods. With the increased demand for green technologies, catalysts play a very significant role in petroleum refinery operations. Furthermore, key refinery processes such as cracking, hydro processing,

On October 27, 2020, Alfa Chemistry Materials, a specialized brand of Alfa Chemistry, announces to provide diverse options of polymer compounds for the global market, which are widely studied in the fields of polymer science (including polymer chemistry and polymer physics), biophysics and materials science and engineering. The application of polymers has a long history. Long ago the mankind started to exploit polymer-containing raw materials to obtain artefacts. And now synthetic polymers are used in nearly all walks of life. “The chemical manipulation of polymers can be dated back to the 19th century. And further development was driven by advances in technology such as innovative synthesis of monomers from cheaper raw materials, more efficient polymerization processes, improved techniques for polymer characterization and advanced theoretical understanding of polymers,” says a senior scientist from Alfa Chemistry Materials. Advantaged by large molecular mass and unique

Hepatocellular carcinoma (HCC) is one of the most common cancers in the world and the third leading cause of cancer deaths. Even though significant progress has been made in standard therapies (such as surgical resection, chemotherapy, and radiation therapy), the results are still disappointing. Therefore, it is necessary to find a new treatment method. There is a brand new field in the field of cancer targeted therapy. Gene-targeted oncolytic virus therapy (GTOVT) is considered to be a promising treatment for HCC. Oncolytic viruses can infect and kill cancer cells without harming normal cells. The anticancer efficacy of oncolytic adenovirus mainly depends on the host`s immune response. As for pathogens, adenovirus triggers a powerful host immune response after infection. This immune response is considered a "double-edged sword" because the oncolytic adenovirus stimulates both antiviral and antitumor immune responses. On the one hand, the host`s antiviral immune response

Creative BioMart, a leading biotechnology company based in NY, provides service to help remove endotoxins (lipopolysaccharides /LPS) from aqueous solutions of a wide range of samples such as proteins, antibodies, vaccines, nucleic acids, buffers and cell extracts with excellent sample recovery rate. Endotoxin, or lipopolysaccharide or LPS, is an integral part of the cell membrane of gram-negative bacteria, such as E. coli. The outer layer of the bacterial outer membrane is composed entirely of endotoxin molecules. A single E. coli cell contains about two million LPS molecules, each consisting of a hydrophobic lipid A moiety, a complex array of carbohydrate residues, and a negatively charged phosphate group. Widely existing in our reagent consumables and samples, it is a major pollution source in biomedical trials and pharmaceutical products, and is one of the most troublesome impurities in the purification process of biological macromolecules such as proteins, nucleic

Before a study enters the first phase of clinical trials, scientists need to spend several years on preclinical research. One of the most important parts includes toxicological research on specific drugs or drugs. Both the FDA and researchers attach great importance to the importance of preclinical safety assessment. According to the FDA`s preclinical safety assessment industry guidelines, pharmacokinetic studies need to include experimental drugs or biopharmaceutical products that represent drugs used in toxicity tests. This route of administration should be similar to that used in clinical trials. In vivo preclinical toxicology studies aim to assess the onset, severity, duration, dose dependence and irreversibility of toxic effects. At Creative Bioarray, in vivo toxicology services range from acute (single dose) to chronic (multi-dose) dosing regimens. Several exposure routes are available in various species such as rodents, rabbits and guinea pigs (for example, oral,

With the development of biomedical research tools, the pressure and demand for stable cell lines has triggered a variety of methods to produce stable, well-characterized cells. Many studies particularly rely on stable cell lines for drug screening and toxicology studies. The practicality of embryonic stem cells and induced pluripotent stem cells has caused some powerful debates because a large number of cells can be produced. If the latter is the case, the specific properties of the patient or disease to be studied can be consistent with the target cells. In terms of reliable differentiation, there are also some limitations. For this purpose, the use of primary cell production cell lines that are more advanced than the early embryonic development stage. The Application of Conditional Cell Immortalization Conditional immortality uses inducible transgene technology to create a cell that can be expanded in a consistent manner when the transgene is active. If the transgene

The human body voltage-induced K + channel hERG plays a basic role in the repolarization of cardiac action potentials and can effectively control the QT interval of the ECG. The recent open-channel cryo-EM structure of hERG should greatly promote the understanding of the molecular basis of hERG channel diseases and drug-induced LQTS. This cardiac function of hERG is the characteristic of its unique gating characteristics: like other voltage-sensitive K + channels, hERG opens due to the voltage-dependent response of its voltage sensor domain after membrane depolarization; however, the channel is almost immediately deactivated, restricting K+ passage until the AP repolarization phase begins. In addition to rapid onset and recovery from inactivation, hERG will also be inactivated very slowly. Therefore, even if the membrane potential returns to the resting potential, an outward K + current will flow. This strongly supports the effective repolarization of cardiac AP. At

A research team led by Professor Hongzhe SUN, Norman & Cecilia Yip Professor in Bioinorganic Chemistry, Department of Chemistry, Faculty of Science, and Professor Kwok Yung YUEN, Henry Fok Professor in Infectious Diseases, Department of Microbiology, Li Ka Shing Faculty of Medicine of the University of Hong Kong (HKU), has discovered a novel antiviral strategy for treatment of COVID-19. They discovered that a class of metallodrugs currently used in the treatment of other infectious diseases is showing efficacy to potently suppress SARS-CoV-2 replication and relieve viral-associated symptoms in an animal model. The findings provide a new and readily available therapeutic option with high clinical potential for infection with SARS-CoV-2. SARS-CoV-2 is an emerging coronavirus that has caused over 30 million laboratory-confirmed cases and more than 1 million deaths globally of COVID-19 since December 2019. As the process of developing an effective vaccine is still ongoing,

For customers who are not familiar with industry regulations, Alfa Chemistry Testing Lab has recently built an exclusive section of regulatory resource section for them on its website for reference purposes. Missioned to provide testing services as efficiently as possible so as to maximize customers` profits, the Lab has constantly intensifying its efforts by providing more valuable insights into the industry in the form of white-papers or flyers. Generally speaking, regulatory institutions will publishes relevant regulations and provides official interpretations on the testing of various items such as drug or alcohol, regarding issues like how to conduct tests, and the evaluation and treatment procedures that are necessary. “The regulations do not stay unchanged. They are changing and evolving with time,” says the Marketing Chief of Alfa Chemistry Testing Lab. “So we build this special section to facilitate our customers and equip them with strong back-up knowledge.

Two new medications commonly used to treat type 2 diabetes are similar in their ability to reduce major heart complications, including heart attack, stroke and death from cardiovascular disease, according to research accepted for presentation at ENDO 2020, the Endocrine Society`s annual meeting, and publication in a special supplemental section of the Journal of the Endocrine Society. One class of drugs, known as SGLT2 inhibitors, has a clear benefit over the other class, known as GLP-1 drugs, in reducing hospitalization for heart failure, the study found. SGLT2 inhibitors are prescription oral medications used to treat type 2 diabetes. They include canagliflozin (Invokana), dapagliflozin (Farxiga) and empagliflozin (Jardiance). The study compared these drugs with injected diabetes drugs known as GLP-1 receptor agonists. These include albiglutide (Tanzeum), dulaglutide (Trulicity), exenatide (Byetta), liraglutide (Victoza) and semaglutide (Ozempic). In prior studies,

Test sieve S 12/38T - Vibrotechnik Test sieves correspond to the accuracy of mesh sizes and perforated plate holes to international standards ISO 3310-1, ISO 3310-2 and provide high reproducibility of sieving. The sieves can be equipped with stainless steel mesh (cell sizes from 20 μm to 10 mm), or with perforated plate with round and square holes (from 1 mm to 125 mm), corresponding to ISO 3310. Characteristics S 12/38T Inner frame diameter 120 mm Overall dimensions: Ø 130 mm, Height 50 mm Mesh size 0,02 – 10,0 mm Size of apertures in perforated plate round holes — 1,0 — 112,0 mm square holes — 4,0 – 80,0 mm Maximum weight of sieve with mesh 0,2 kg Maximum sample weight for sieve with mesh 0,1 kg Maximum sample weight for sieve with perforated plate 0,3 kg

Test sieve S 20/50T - Vibrotechnik Test sieves correspond to the accuracy of mesh sizes and perforated plate holes to international standards ISO 3310-1, ISO 3310-2 and provide high reproducibility of sieving. Characteristics Inner frame diameter 200 mm Overall dimensions: Ø 212 mm, Height 70 mm Mesh size: 0,02 – 10,0 mm Size of apertures in perforated plate: round holes —1,0 — 125,0 mm square holes —4,0 – 125,0 mm Maximum weight of sieve with mesh 0,5 kg Maximum sample weight for sieve with mesh 0,2 kg Maximum sample weight for sieve with perforated plate 0,5 kg

Test sieve S 20/100T - Vibrotechnik Test sieves correspond to the accuracy of mesh sizes and perforated plate holes to international standards ISO 3310-1, ISO 3310-2 and provide high reproducibility of sieving. The sieves can be equipped with stainless steel mesh (cell sizes from 20 μm to 10 mm), or with perforated plate with round and square holes (from 1 mm to 125 mm), corresponding to ISO 3310. Characteristics Inner frame diameter 200 mm Overall dimensions: Ø 212 mm, Height 115 mm Mesh size 1,0 -10,0 mm Size of apertures in perforated plate: round holes — 1,0 — 125,0 mm square holes — 4,0 – 125,0 mm Maximum weight of sieve with mesh 0,6 kg Maximum sample weight for sieve with mesh 0,5 kg Maximum sample weight for sieve with perforated plate 0,5 kg

Test sieve S 30/50T - Vibrotechnik Test sieves correspond to the accuracy of mesh sizes and perforated plate holes to international standards ISO 3310-1, ISO 3310-2 and provide high reproducibility of sieving. The sieves can be equipped with stainless steel mesh (cell sizes from 20 μm to 10 mm), or with perforated plate with round and square holes (from 1 mm to 125 mm), corresponding to ISO 3310. Characteristics Inner frame diameter 300 mm Overall dimensions: Ø315 mm, Height 70 mm Mesh size 0,032 – 10,0 mm Size of apertures in perforated plate: round holes — 1,0 – 125,0 mm square holes — 4,0 – 125,0 mm Maximum weight of sieve with mesh - 1,0 kg Maximum sample weight for sieve with mesh 0,3 kg Maximum sample weight for sieve with perforated plate 1,0 kg

Test sieve S 30/100T - Vibrotechnik Test sieves correspond to the accuracy of mesh sizes and perforated plate holes to international standards ISO 3310-1, ISO 3310-2 and provide high reproducibility of sieving. The sieves can be equipped with stainless steel mesh (cell sizes from 20 μm to 10 mm), or with perforated plate with round and square holes (from 1 mm to 125 mm), corresponding to ISO 3310. Characteristics Inner frame diameter 300 mm Overall dimensions: Ø315 mm, Height 110 mm Mesh size: 1,0 — 10,0 mm Size of apertures in perforated plate: round holes — 1,0 — 125,0 mm square holes — 4,0 – 125,0 mm Maximum weight of sieve with mesh 1,4 kg Maximum sample weight for sieve with mesh 0,75 kg Maximum sample weight for sieve with perforated plate 1,0 kg

Test sieve S 40/70T - Vibrotechnik Test sieves correspond to the accuracy of mesh sizes and perforated plate holes to international standards ISO 3310-1, ISO 3310-2 and provide high reproducibility of sieving. The sieves can be equipped with stainless steel mesh (cell sizes from 20 μm to 10 mm), or with perforated plate with round and square holes (from 1 mm to 125 mm), corresponding to ISO 3310. Characteristics Inner frame diameter 400 mm Overall dimensions: Ø440 mm, Height 85 mm Mesh size 0,2 – 10,0 mm Size of apertures in perforated plate: round holes — 1,0 — 125,0 mm square holes — 4,0 – 125,0 mm Maximum weight of sieve with mesh 3,5 kg Maximum sample weight for sieve with mesh 0,6 kg Maximum sample weight for sieve with perforated plate 2,0 kg

Test sieve S 40/140T - Vibrotechnik Test sieves correspond to the accuracy of mesh sizes and perforated plate holes to international standards ISO 3310-1, ISO 3310-2 and provide high reproducibility of sieving. The sieves can be equipped with stainless steel mesh (cell sizes from 20 μm to 10 mm), or with perforated plate with round and square holes (from 1 mm to 125 mm), corresponding to ISO 3310. Characteristics Inner frame diameter 400 mm Overall dimensions: Ø440 mm, Height 150 mm Mesh size 1,0 – 10,0 mm Size of apertures in perforated plate: round holes — 1,0 — 125,0 square holes — 4,0 – 125,0 mm Maximum weight of sieve with mesh 4,5 kg Maximum sample weight for sieve with mesh 1,0 kg Maximum sample weight for sieve with perforated plate 2,0 kg

As a global leading supplier of of raw materials, antibodies, and reagents for bio-technology industry, Creative Diagnostics now launches SARS-CoV-2 immunoassay kits for direct detection of the new coronavirus and antibodies against SARS-CoV-2. New immunoassay kits including SARS-CoV-2 IgG elisa kit, SARS-CoV-2 IgM elisa kit, SARS-CoV-2 Antigen ELISA Kit, and SARS-COV-2 Total Antibody ELISA Kit are available at Creative Diagnostics. The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, previously named 2019 novel coronavirus or 2019-nCoV) disease (COVID-19) at the end of 2019 has become a global pandemic and an unprecedented public health issue. Creative Diagnostics started developing a new test shortly after the outbreak has become known. Only a few weeks later, two ELISAs for the detection of Anti-SARS-CoV-2 antibodies of classes IgM and IgG and one ELISA for the detection of SARS-CoV-2 NP antigen were available. Both test systems are currently

Pumps are among the most important and widespread machines built and used by people all around the world. Pumps are among the most important and widespread machines built and used by people all around the world. They are used to transport liquids, gases or compounds or to increase pressure and overcome height differences and physical distances. Peristaltic tube pumps are positive displacement pumps and at Spetec, they are made up of a roller head driven directly by a wear-resistant stepper motor and an arrangement for securing the tubing used. This type of pump operates on the principle of constantly compressing and releasing a tubing. The tubing is pressed into holders around a rotating roller head using pressure arms. The liquid is thus conveyed along the occlusion point of the tubing by an alternating surface of the roller head caused by the rollers and their movement. The first tube pumps were initially used to pump blood in the 1960s. They soon found their way into industrial applications as self-priming pumps of this kind are very easy to use and are also suitable

Mobiele ACA RoQ-hardheidsprofiler Eenvoudige identificatie van rolproblemen met de mobiele ACA RoQ-hardheidsprofiler. Vermijd problemen met de verwerkbaarheid en verbeter de rolkwaliteit. Het rolhardheidsprofiel is een belangrijke parameter die een goede rol definieert. RoQ rolkwaliteitsanalyser is de nieuwste innovatie op het gebied van profielmeting van een rol. De RoQ genereert automatische, en met een eenvoudige meetprocedure, reproduceerbare profielen met hoge resolutie. Toepassingen, o.a papier, dunne films en multilaagse laminaten voor productie- en ingangscontrole.

Planetary ball mills PBM 1-4 PBM 1-4 planetary ball mill is designed for fine grinding of materials of different hardness in batch mode. The grinding can be performed dry or wet. In a planetary ball mill , grinding occurs due to impact destruction during the motion of balls, as well as abrasion - simultaneous compression and shear deformation. The size of the crushed material particles depends on the running time of the mill, the physical properties of the material, the volume of material loaded, as well as the volume of balls loaded. Recommended volume of material loaded in one bowl: 15 - 45 cm3, recommended volume of balls loaded in one bowl: 50 - 130 cm3. PBM 1-4 planetary ball mill can be used as a mixer for the preparation of emulsions, suspensions and slips. See more: Maximum initial material grain size - 3 mm Axis arrangement- vertical Mohs hardness of grinded material - 8 up to Loading volume of one bowl - 15-45 cm3 Number of bowls - 4 Full volume of one bowl 230 cm3 50 Hz supply voltage

2021 will bring global pharma community back together in person to drive business growth CPhI Worldwide (31 August – 2 September 2021) will be held next year in Milan (Fiera Milano) for the first time in over a decade – following its postponement in 2020. The event returns at an apt moment, as the pharma industry in Italy is anticipated to be one of the main beneficiaries of geo-diverse sourcing strategies. Italy is Europe’s largest producer and exporter of APIs – 85% are exported to North America, the EU and Japan[1] – and the 2020 CPhI Annual Report Survey indicates the country is well set for growth in 2021, as pharma looks for new manufacturing partners. The results show that Italy has improved its ‘growth ranking’ by 16% in a year – the largest rise of any country – with Western European API manufacturers predicted to be the ‘biggest beneficiaries of supply chain changes’ by some 47% of respondents. To further empower the industry’s growth, CPhI Worldwide 2021 will implement a ‘hybrid event model’, featuring onsite exhibition and conference agenda,

What are the benefits of using two probes measuring two different parameters? Dual-probe support refers to the ability of a single transmitter or monitoring device to interface with two independent measurement devices, and then display, record, and transmit their data. It allows multiple parameters, or redundant parameters to be more easily monitored in the same space, or in different locations. What are the benefits of using two probes measuring two different parameters? Often an environment or process requires monitoring in multiple locations, and for a number of different parameters. It is common to be monitoring both the inlet and exhaust conditions of a single process to ensure product quality and energy efficiency. When the mounting space is limited, one transmitter with two probes is a useful and practical choice, for example, oil processing facilities with multiple oil dehydrators, or bread-proofing (multiple ovens) where one transmitter could monitor two separate ovens. The life science industry often monitors multiple parameters in

Creative Enzymes, a professional enzyme provider located in New York, USA, always hammers at researches and trials in order to provide customers with various enzyme services as many as possible. Last week, the product manager of Creative Enzymes announced the technical escalation for enzymes in oncology and thrombus treatment, to treat cancer through disturbing the metabolism of the amino acid in cancer cells. With the latest advances in biotechnology and modern medicine, the application of enzymes in therapeutic agents has grown rapidly. More and more therapeutic enzymes are participating in medical research, and some are therapeutic candidates, especially those related to diseases such as cancer and thrombosis. To facilitate this kind of work, Creative Enzymes provides a variety of high-quality enzymes. “Creative Enzymes has long demonstrated expertise and reliability in the development of therapeutic enzymes. With decades of experience and unique technology, we

CD Genomics is a genomics service company with good reputation in providing reliable microbial sampling products, microbial testing services, microbial genomics services, and integrated bioinformatics services. These days, the product manager of CD Genomics announced microecology and human health solutions to help you harness the potential of this promising therapeutic area. Generally, the microorganisms in the human host are responsible for resisting the colonization of foreign pathogenic microorganisms. However, sometimes potential pathogens come into close contact with humans and cause opportunistic infections in immunocompromised hosts. Some microorganisms have special functions that are known to be useful to human hosts, but the role of most resident microorganisms remains unclear. In addition, based on evidence, scientists now believe that modern dietary trends, overuse of antibiotics, and obsession with cleanliness can all disrupt the delicate balance and cause

New ‘blockchain ecosystem’ has potential to track, from vein-to-vein, advanced therapies 19 October, 2020: ATMPS Ltd – a spinout of FarmaTrust announces that its Hataali blockchain platform has been successfully tested with University Hospitals Birmingham NHS Foundation Trust’s system interface. Data interoperability was shown to be possible, rendering the Hataali platform as the world’s first blockchain solution for advanced therapeutic medicinal products. Hataali[1] is a new pioneering blockchain-based cell orchestration platform that is interoperable with any other stakeholder interface and is designed to track advanced therapies from vein-to-vein. University Hospitals Birmingham NHS Foundation Trust (UHB) hosts the Midlands and Wales Advanced Therapy Treatment Centre (MW-ATTC), which is a consortium of NHS, academic and industry partners. The MW-ATTC – supported by Innovate UK – is one of three centres in the ATTC network across the UK working together to accelerate ATMP delivery in the NHS. The informatics work, led by UHB within the MW-ATTC, proposes

Amazingly good value particle analyser with software that’s fun to use The Fritsch Analysette 28 ImageSizer for dry and wet measurement is the ideal Particle Sizer for all applications that require accurate and reproducible measuring results for both particle shape and size. The optical method of dynamic image analysis delivers results for particle sizes from 20 μm to 20 mm with a multitude of shape parameters and evaluation options. Your advantage: excellent flexibility for different measurement tasks. Even agglomerating samples can be processed easily by using the optional wet dispersion unit. The Top Advantages of the Analysette 28 ImageSizer - Ideal for powders and bulk solids as well as for suspensions and emulsions - Costs 50 % less than comparable competitor products for most applications - State-of-the-art software that’s fun to use – including single image analysis of individual particles upon a mouse click - Fast evaluation at high image resolution – up to 75 images per second in microscopy quality For fast single image

Thaw up to 10 racks of tubes in as little as 9 minutes The SPL Guard Florida is a rack thawing station that can thaw up to 10 racks in as little as 9 minutes. It can be used as a stand-alone system or integrated into a robotic workstation like a liquid handler. When the SPL Guard Florida is fully loaded with racks, it can thaw samples 60% faster than any other instrument on the market. By thawing samples at a consistent rate and temperature, the SPL Guard Florida reduces uneven thawing, guaranteeing sample integrity for downstream research. No excess input of heat, calibration, or maintenance is required to operate the Florida.

Brandenburg, Germany, 15 October 2020: Sirio Europe – the leading European nutraceutical and pharmaceutical contract development and manufacturing organisation (CDMO), part of the Sirio group – announces the completion of a major overhaul of its Brandenburg site with advanced manufacturing and green technologies. The company has installed new HVAC systems, individual drying chambers, vegetarian softgel manufacturing equipment and a block heat & power plant. The improvements were implemented as part of Sirio Europe’s continuous efforts to further improve the quality and sustainability of manufacturing. “One of the reasons behind the investments was that we wanted to be at the forefront of implementing greener solutions and energy-efficient manufacturing for our pharma customers. So while implementing new equipment, we also explored how we can improve the plant’s sustainability.” commented Dominique Baum, Managing Director at Sirio Europe The HVAC systems increase

The third part of the 2020 CPhI Annual Report – released during the second week of the CPhI Festival of Pharma (5-16 October, 2020) – predicts, that if approved, COVID vaccines and therapeutics will cause an impending biomanufacturing capacity challenge, particularly for large scale reactors. CPhI Annual Report expert, Dawn M. Ecker – Managing Director of bioTRAK Database Services at BDO – explores the medium- to long-term implications of supply and demand for biologics manufacturing. Her findings show that short-term capacity concerns have eased, but beyond 2024 we may see capacity challenges. The primary variable in future commercial capacity needs will be the progress of Alzheimer’s drugs, PDL/PDL-1 checkpoint inhibitors and Covid therapeutics currently in late stage development. Ecker reports that global bio-manufacturing capacity will increase to 6500kL by 2024 at a CAGR of 6.4% – up from 4700kL in 2019 – but capacity demand is rising faster and will reach 4700kL

The CPhI Awards Recognize Excellence in Pharma The winners of the 17th annual CPhI Pharma Awards, Powered by Informa Pharma Intelligence, were announced at its first-ever virtual ceremony on 13 October 2020. Since 2003, the CPhI Pharma Awards have recognised outstanding achievement in the pharmaceutical and biopharmaceutical industry, and this year’s digital event was no exception. Each category at the prestigious Awards ceremony celebrated the individuals, teams, and organizations committed to driving the industry forward. This year’s Awards featured fourteen categories, including – fittingly – the newly added Excellence in Pharma: Innovation in Response to COVID-19 category. Tara Dougal, Head of Content at Informa commented: “This year has been a truly ground-breaking year for innovation in the pharmaceutical industry as demonstrated by the quality of the entries for the CPhI Pharma Awards covering all parts of the pharmaceutical supply chain. The judges have tirelessly worked to ensure that all award submissions

Applying AI models to actual drug R&D projects will help researchers improve the efficiency of preclinical drug discovery. The AI-driven drug discovery platform aims to cover the entire process of preclinical new drug development, including protein structure prediction, virtual screening, molecular design/optimization, ADMET prediction, and synthetic route planning. The importance of algorithm in AI AI helps drug research and development, and the three elements of AI—algorithm, computing power, and data, are indispensable and complementary. Advanced algorithms can deeply mine the existing big data and analyze the hidden relationships. This process not only directly assists the discovery of new drugs, but also integrates a large number of existing databases, while promoting the generation and accumulation of new data, and better optimization of algorithms. The optimized algorithm in turn can reduce the model`s dependence on the amount of data and improve the model`s

With continuous enhancement of deep learning technology, artificial intelligence (AI) is constantly expanding its boundaries. In the medical field, the application of AI is often manifested in assisting diagnosis of early tumors, or helping complete the electronic medical record. But in addition to that, AI can also play a significant role in drug discovery, which traditionally relied heavily on random discovery in the past. The combination of AI and experimental verification (hybrid-method) can accelerate the development of a new generation of targeted therapy drugs, and can also provide more alternative treatment options for cancer patients. The purpose of patients using drugs is to change the conformation of disease-causing proteins so that they can be degraded and eliminated. To obtain the conformational information of proteins, the traditional method is through experiments. However, the limitations of this method are obvious. On the one hand, it is difficult to

Voice-driven AI used to transmit patient information in home and hospital, with newly genericized small molecu Amsterdam, 08 October 2020: The second part of the 2020 CPhI Annual Report predicts significant market changes for digital adoption and global generic consumption by 2025. The new findings are released as the industry prepares to meet virtually at the CPhI Festival of Pharma, and suggest that digital technologies will help deliver lower healthcare costs through telemedicine and bring innovator-like approaches for generic companies. CPhI experts Bikash Chatterjee, CEO at Pharmatech Associates and Aurelio Arias, Engagement Manager, Thought Leadership, IQVIA explore the longer-term implications of slowing growth in the generics market – with many products coming off-patent – and how digital solutions are transforming health and pharma structures. Chatterjee suggests that patient centricity is no longer just a buzzword and change is accelerating. Telemedicine and, in particular virtual GP appointments, will be one lasting legacy of the pandemic, but payers and insurance

LabMakelaar Topoccasion The Biostat B-DCU is a fermenter/bioreactor specifically designed to accommodate the requirements of process optimization and characterization in the biotech and biopharmaceutical industry. It provides enhanced functionality and an unrivalled level of options for cell culture and microbial processes making it the ideal scale-down model for your large scale process. System consists of: 1x Sartorius Stedim BioPat dcu control Tower 4x Sartorius Stedim Biostat B-DCU Bioreactor Unit 4x Sartorius Stedim Univessel SU Reactor Holder 8x Sartorius PMA7501 Scale 4x Sartorius BB Reactor Heating Blanket 4x Sartorius Filter Heater

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by Accenture This Academy Webinar presentation from Accenture is about about helping clients gather data and facilitate an electronic batch record, resulting in less stress, and less time to release the batch. This presentation and discussion will explore the imperative for digital transformation in the context of the pharmaceutical laboratory, plant and supply chain – all in the context of the exceptional times and new digital normal we are all adapting to.

Old chromatography equipment is of great value for laboratories in 2nd and 3rd world countries. What do you do with old chromatography equipment? Many laboratories in the Netherlands and Belgium have old equipment, which is dusting in a corner of the laboratory or warehouse. And then…? We offer you the solution, whereby in most cases it is not only collected by us, but also gets a second life. What we ask of you is a photo with a short description to WhatsApp or email us. It will only take you a few minutes. You will hear within a day,whether we can take over from you. The information we only need from you is: 1. Manufacturer and model 2. Detailed photo or photos 3. Year of purchase 4. Are PC and software included? Help us care for our fellow human beings and a better environment together.

Organisers have also confirmed the launch of a virtual CPhI China and enhanced online platforms to keep the in Amsterdam, 05 October 2020: Informa Markets announces its complete listing of pharma event dates for 2021 at the opening of the first CPhI Festival of Pharma (05 - 16 October 2020) – the largest ever virtual pharma event. The pharma schedule includes one further event in 2020: CPhI China, 16-18 December (hybrid event, combining “live” in-person with “virtual”). In 2021, all eight international CPhI editions [Worldwide, India, China, North America, Middle East & Africa, South East Asia, Korea and Japan] will return in full along with Pharmapack Europe. The 2021 events will be enhanced by digital elements, providing greater networking and learning opportunities to the global pharma industry, with the complete pharma portfolio resuming late spring onwards. “We are thrilled about coming together with the pharma community again at CPhI Festival of Pharma, and we wanted to give details of all our pharma events for the year ahead. In 2021 we are implementing a hybrid model

The CPhI Festival of Pharma (5 – 16 October 2020) is the world’s largest virtual pharmaceutical trade show and features a Massive two-weeks of events playing host to 20,000+ attendees from over 700 companies. The CPhI Festival of Pharma has been created to fill the gap left by in-person events and mixes informative content, networking opportunities and a virtual marketplace. But crucially, all of which can be enjoyed from the comfort of your own home or workplace. It will feature CPhI’s largest ever content agenda spanning more than 50 different sessions including webinars, podcasts, interviews, and panel discussions with top industry executives. There will be the CPhI Awards and Women in Leadership Forum, as well as the digital marketplace and matchmaking platform to facilitate business via virtual means. “Beyond our incredibly broad content agenda we are also extremely proud to offer the industry unparalleled virtual networking facilities, including our state-of-the-art