News items November 2020

As one of the world’s leading chemical and pharmaceutical suppliers in the last decades, BOC Sciences provides impurity isolation and identification services for scientists and researchers who are devoted to drug development research. We now offer impurity removal, API purification, and product upgrade services through multiple drug analytical technology platforms. Drug quality is related to the health and safety of drug users, so the impurities of listed drugs are more and more strictly controlled in many countries. In the process of drug development, liquid chromatography-mass spectrometry (HPLC-MS) is not only one of the commonly used techniques in drug impurity analysis, but also one of the effective means for qualitative and quantitative analysis of impurities that may be produced by drugs. With the continuous development of the pharmaceutical industry, HPLC-MS is also developing into one of the most important tools in the fields of life science, medicine, clinical,

Recently, Boc rna and Shiyue Fang`s team at Michigan Technological University reached a cooperative consensus to conduct sensitive DNA/RNA synthesis. DNA/RNA can coexist with many sensitive organic functional groups. However, DNA/RNA analogs containing these groups cannot be obtained through the current technologies on the market. It is reported that the new technology developed by Shiyue Fang`s group using Dim-Dmoc phosphoimide and Dmoc supports can be used for sensitive DNA/RNA synthesis. This new technology is generally applicable to the synthesis of DNA/RNA containing a variety of sensitive groups. Sensitive DNA/RNA analogs obtained using Dim-Dmoc technology can be used in the study of protein interactions, the origin, function, disease association research of naturally occurring sensitive DNA/RNA analogs, the development of antisense drugs, DNA/RNA-based disease diagnosis, and synthesis of mRNA drugs. About Dr. Fang The current projects of Dr. Fang`s research

The new report looks ahead to a post-pandemic 2021 with pharma manufacturing capacity and payment structures s A new report from CPhI explores the potential implications in 2021 of impending vaccine approvals, a new administration in the White House and a return to dual supply chain strategies. The report – which summarises expert analysis into 12 key findings – foresees a particularly positive outlook for the pharma manufacturing supply chain, as a result of the demand for increased second source contingencies, alongside the huge scale-up of vaccine capacity currently underway. A consequence of which is likely to encourage expansion across the contract services sector for all product classes and therapy areas. Interestingly, the CPhI report highlights that ‘forgotten priorities’ of recent years like AMR (anti-microbial resistance), and continuous manufacturing will return – with the latter potentially simulating new manufacturing approaches for novel applications like RNA technologies. For example, two of the new COVID vaccines approaching approval use RNA technologies and,

Scientists in the field of protein engineering and analysis now have access to the newly updated de novo protein design service, an attractive approach for constructing designed proteins with predetermined structures and functions. The process of protein molecular design mainly relies on the determination of protein structure and the establishment of molecular models. According to the relationship between protein structure and function, the technical methods of various disciplines are comprehensively used to ensure that new proteins with better performance than natural proteins can be obtained. The amino acid residues on natural protein molecules with a known structure can be used to study and improve the properties and functions of proteins; it is also possible to splice and assemble the domains of different proteins from different sources to transfer the corresponding functions, thereby obtaining protein molecules with new characteristics; It is possible to design

Profacgen, with years of experience in bioconjugation services, now provides a full spectrum of quality solutions from single reagents to comprehensive PEGylation service to meet different needs. The introduction of polyethylene glycol (PEG) into biomolecules and drugs enhances the stability and pharmacological properties of proteins, peptides, antibody-drug conjugates, and small molecule drugs. As a synthetic polymer with high hydrophilicity, PEG is widely used to prolong the circulation time of proteins, increase the water solubility of therapeutic molecules as well as reduce the immunogenicity of biological drugs. To date, PEGylation has been used successfully in 12 commercially available drugs. The earliest PEGylation technology for protein modification has recently been transferred to small molecule drugs, which has triggered a new wave of research boom in the pharmaceutical industry. The binding of PEG has been shown to be a powerful tool for dissolving biomolecules,

Creative Biogene, as a scientists-founded and scientists-driven leading biotechnological company, focuses on developing high quality products and services to support the research in the field of basic life sciences research, biomedical development, industrial synthetic application and preclinical drug discovery. Recently, Creative Biogene announced the relsease of its adjuvants products in order to accelerate vaccine development and related research. Creative Biogene has advanced equipment, technology and experienced staff, and can provide customers with a series of high-quality adjuvant products for vaccine development, such as Freund`s adjuvant, bacterial-derived adjuvant, and fee-based receptor agonist and CpG ODN. Creative Biogene offers the largest selection of vaccine adjuvants. They have been approved for human vaccination or are still under research. They include granular adjuvants, such as alum and emulsions, and molecules known to activate pattern recognition

IntergrateRNA, a major branch of Creative Biogene, is a leading global provider of high quality products and services provider for RNA discovery, expression analysis, as well as aims at exploring potential treatments for high-impact diseases and promoting the development of the RNA research field. Recently, IntergrateRNA announced its tRNA services in order to support its applications in complex human pathologies and other bioinformatics research. As a global biotechnology company specializing in RNA research, IntergrateRNA provides products and services to various genomic researchers in the market, including various types of RNA discovery, analysis and related bioinformatics services. IntegrateRNA provides a comprehensive range of high-quality tRNA related services. All tRNA synthetase products undergo strict quality control and are independently developed by a team of professional scientists. IntergrateRNA provides custom tRNA Synthetase Service, including but not

AAV vectors have achieved positive results in many clinical and preclinical settings, including blood system diseases such as hemophilia, Gaucher`s disease, hemochromatosis and porphyria. Small clinical studies allow researchers to analyze the immune response to AAV vector capsids and transgene products and develop strategies to manage these responses to achieve long-term expression of therapeutic genes. However, there is still a lack of a comprehensive understanding of the determinants of the immunogenicity of AAV vectors and the potential associated toxicity. As part of ongoing clinical research, careful immune monitoring will provide a basis for understanding the complexity of the immune response in AAV-mediated gene transfer, thereby contributing to safe and effective treatment of genetic diseases. The AAV vector is modified from the naturally occurring parvovirus adeno-associated virus. AAV does not replicate automatically, but relies on helper viruses (such as

Creative BioMart, a leading supplier that focuses on developing high quality protein products and efficient protein manufacturing techniques, provides a wide selection of adaptive immunity proteins to support needs in immunology studies. Immunology is a broad branch of biomedical science that covers the study of various aspects of the immune system of all organisms. It involves the physiological functions of the immune system in health and disease states; abnormal functions of the immune system (autoimmune diseases, hypersensitivity, immunodeficiency, transplant rejection); and physical, chemical, and physiological properties of various components of the immune system in vitro, in situ, and in vivo. Immunology has applications in several disciplines of science and is therefore further subdivided. The adaptive or specific immune system mainly attacks specific invaders. It consists of highly specialized cells known as thymus-derived T lymphocytes and bone marrow-derived

Dyes are indispensable in our daily life because they are widely applied in manufacturing like paper, leather, fur, hair, drugs, cosmetics, waxes, greases, plastics and textile. In response to the growing demand for dyes, Alfa Chemistry, a New York-based chemical supplier, announced to offer rich choices of dyes that can be used in various industrial scenarios.   A dye is a colored substance that chemically bonds to the substrate to which it is being applied. Compared with dyes, pigments do not chemically bind to the material they color. Dyeing is believed to have originated in Neolithic times, about 4000 to 9000 years ago. Dyes are usually soluble in water. There are natural dyes and synthetic dyes. Most natural dyes have plant origin and can be extracted from roots, berries, bark, leaves, wood, fungi and lichens. However, most synthetic dyes are made synthetically from petrochemicals.   Alfa Chemistry provides many types of dyes, including acid dyes, azoic dyes, basic

Alfa Chemistry Materials Provides Crosslinking Agents for Polymer Materials On November 17, 2020, Alfa Chemistry Materials, an expert in specialized materials, announces to release a range of crosslinking agents for the global market, which could be used for the betterment of polymer materials. As crosslinking agents can transform linear or lightly branched macromolecules into a three-dimensional network structure and improve their performances in regard with strength, wear resistance, heat resistance, and solvent resistance, they are widely added to resins. “Crosslinking is a type of polymerization reaction that branches out from the main molecular chain to form a network of chemical links, and in this process, cross-linking agents are added to resins,” says a senior scientist from Alfa Chemistry Materials. “Cross-linking agent works by creating chemical bonds between the linear molecules, so as to improve the strength and elasticity of the rubber. Crosslinking

On November 17, 2020, Alfa Chemistry Catalysts, a specialized sub-brand of Alfa Chemistry, proudly announced the release of varieties of catalysts for water treatment, including Zero valent iron (ZVI), Fe₂(SO₄)₃, FeSO₄, FeCl3, and FeOOH, which have long been used in water and wastewater treatment. Due to the growth in population, there are quite large demand for fresh, safe and clear water. Agricultural irrigation and industrial usage are two fields where water is also intensively consumed. Therefore, it is if paramount importance to find improved methods to inexpensively and sustainably clean water. “Traditionally, the most widely applied water treatment technologies include a combination of coagulation, sedimentation and filtration. But they have shortcomings. In recent years, catalysts, especially heterogeneous catalysts, have become the first choices to directly convert toxic molecules in water to nontoxic products due to its good activity

As the fastest growing class of materials in chemistry today, metal-organic frameworks (MOFs) have become ideal candidates for storage of fuels (hydrogen and methane), capture of carbon dioxide, and catalysis applications as well as many other applications. To meet the increasing market demand accompanying this trend, Alfa Chemistry has recently launched a subsidiary website, which is specially designed for supplying MOF chemicals, COFs linkers, and MOF materials. MOFs are made by linking inorganic and organic units by strong bonds through reticular synthesis. Due to the flexibility and variation of the constituents’ geometry, size, and functionality, there have been more than 20,000 different MOFs reported and studied since the discovery of the first MOF structure in the 1990s. And the number still grows daily. “Up till now, MOFs with permanent porosity are more extensive in their variety and multiplicity than any other class of porous materials,” says a senior scientist

 Founded in Ronkonkoma, New York, 2009, Protheragen has been serving as a bridge between academics and industry. It recently announced an opportunity for the acquisition of Complete Pentapeptide Library for researchers and companies who are engaged with peptide therapeutics discovery. This library platform can be used to screen potential candidates in drug discovery projects.   Constructing complete peptide libraries such as a complete pentapeptide library is now an improved peptide library preparation method. The Complete Pentapeptide Library offers by Protheragen has made many breakthroughs. First, it provides nearly 0.5 billion peptide sequences. Second, the affinity purified 75,000 cyclic peptides can bind to desired targets for high-throughput screening. Last but not least, the library makes drug development more efficient and less costly.   In the past decades, peptide therapeutics enjoys growing popularity for the treatment of many diseases such as tumors, cardiovascular

On November 19, 2020, AI & Medicine, an expert of AI-assisted medicine, announces that its artificial intelligence-powered systems are capable of analyzing data from hundreds of sources and accordingly offer predictions about what works and what doesn`t. This would greatly help scientists and researchers more efficiently and wisely make choices in drug discovery and development attempts. Ever since its founding, AI & Medicine has been known for its expertise in applying AI into drug discovery, personalized healthcare and various other medical applications. As a very critical step in drug discovery, data analysis used to be time-consuming, labor-intensive. But now with the help pf AI systems, it has been streamlined and can be accomplished within much shorter time frame. AI systems are able to process various data types, either structured data or unstructured data, in a fast manner and return with reliable results or predictions. “Nowadays, big data analysis using

AI & Medicine Owing to its powerful computing power and ability to discover relationships, artificial intelligence (AI) is applied in multiple procedures of new drug R&D. It can assist in discovering both explicit and hidden relationships between drugs, diseases, and genes, which would take a lot of work for drug experts if done manually. In terms of computing, AI possesses powerful cognitive computing capabilities, which can perform virtual screening of candidate compounds, quickly screen out compounds with higher activity, and prepare for later clinical trials. According to statistics, AI is mainly used in 7 big scenes of new drug development, including target discovery, compound synthesis, compound screening, crystal form prediction, patient recruitment, optimization of clinical trial design, and drug redirection. AI can save 40%-50% of the time in compound synthesis and screening compared with traditional methods, saving pharmaceutical companies US$26 billion each year in terms

AI & Medicine The past decade has witnessed an year-by-year increase in the number of patients diagnosed with cancer and diabetes worldwide, and at the same time, drug research and development is carrying out intensively. According to data reported, the global pharmaceutical R&D investment in 2016 was US$145.4 billion (excluding pharmaceutical production investment), and the compound annual growth rate from 2012 to 2016 was 2.4%. In the context of rising new drug R&D costs, it is estimated that global pharmaceutical R&D investment will reach 160 billion US dollars in 2021, and the compound annual growth rate will reach 1.9% from 2016 to 2021. Although the global enthusiasm for new drug research and development is high, it is not easy to make commendable achievements. It is estimated that the successful launch of a new drug often carries an average R&D cycle of more than 10 years and a R&D cost of more than 2 billion USD. In addition, the research and development process of a new

To help scientists and researchers specify and solve problems related to impurities, the New York-based analytical company Alfa Chemistry Testing Lab launched to provide a series of pharmaceutical impurity testing services, for purposes of making the drugs being developed comply with regulatory requirements and at the same time providing safe and effective commodities for consumers. Impurities in drug substance can come from nearly all stages of drug development, for instance, in the synthetic/manufacturing processes. Storage container, excipients and many others can be sources of impurities as well. In other words, the emergence of impurities is almost unavoidable. To ensure that impurities do not affect the efficacy of drugs, they should be controlled within a level. However, study of impurities in pharmaceuticals is one of the most time-consuming and challenging tasks, so choose a third-party organization to conduct impurity testing would be a wise choice. “Excessive

Reference standards play a pivotal role for testing labs. To ensure the validity of results in any type of testing, either environmental samples processing or testing pharmaceuticals, reference standards are a must. On November 17, 2020, Alfa Chemistry announced to provide varieties of chromatography standards, mainly for the purpose of calibration. Along with supply of other chemicals, Alfa Chemistry has become a trusted source of high-quality organic reference standards. Chromatography standards have a known concentration and are often used to test separating equipment so as to ensure that there are no performance faults. Analytical equipment error would impact the dependability of retention time, purity, molecular weight, and compound identification conclusions, all of which should be avoided. “Improving data quality, the substances allow laboratory personnel to plot analyte signal ratios and obtain concentrations from a calibration curve. Chromatography standards

In a recent statement, Alfa Chemistry’s cGMP-compliant laboratory—Alfa Chemistry Testing Lab announced that it is capable of conducting caffeine testing. The lab is increasingly recognized by its customers to be trust-worthy, professional and reliable. On the one hand, all testing are conducted using the most advanced analytical methods and equipment. On the other hand, the lab’s scientists are constantly adapting to the changing regulations and ongoing needs. While coffee has become one of the most popular beverages in the world, FDA issues warnings to consumers about high concentrations of caffeine products, which are believed to be not healthy. Caffeine is a powerful stimulant, and very small amounts of pure caffeine or high concentrations of caffeine can lead to serious or even fatal outcomes. Symptoms of overdose of caffeine include rapid heartbeat, tremors, vomiting, diarrhea, unstable walking and coma. “The main ingredient in coffee is caffeine. Some teenagers

In Vitro Screening is a screening process used to find a small number of compounds with the desired biological activity in a large collection. The basic premise of screening is that biological assays are repeatable, reliable, robust and biologically relevant. Creative Bioarray provides a range of products and services that can speed up your drug discovery program, with the goal of providing innovative tools that make drug development more efficient, cost-effective and more successful. Analytical development is an objective method of screening putative compounds to determine target interactions or modifications. A better understanding of the specific pathways involved in the etiology of diseases can help researchers develop more comprehensive assays using emerging tools and technologies. In the design phase, analysis conditions and steps are selected to minimize potential sources. The false positive and false negative hit rate is related to the selectivity and sensitivity

The development of compounds from discovery to clinical is a huge and expensive decision, which must be based on correct information. Due to the huge in vivo model library, the extensive experience of in-house scientists, the in-depth research on pharmacology, as well as the proprietary technology platform, Creative Bioarray has a large number of widely validated preclinical models. There are more than 300 proven animal models of diseases, covering more than 40 different diseases in the fields of cancer, bone, autoimmunity and inflammation. There is a major obstacle to the evaluation of new human immunotherapies due to a lack of experimental models with a fully functional human immune system. Therefore, the development of humanized experimental models still is an unmet need in immunotherapy research. Creative Bioarray is commitment to furthering immuno-oncology research, at present, developing a humanized mouse model that utilizes the human immune system against human

The human body voltage-induced K + channel hERG plays a basic role in the repolarization of cardiac action potentials and can effectively control the QT interval of the ECG. The recent open-channel cryo-EM structure of hERG should greatly promote the understanding of the molecular basis of hERG channel diseases and drug-induced LQTS. This cardiac function of hERG is the characteristic of its unique gating characteristics: like other voltage-sensitive K + channels, hERG opens due to the voltage-dependent response of its voltage sensor domain after membrane depolarization; however, the channel is almost immediately deactivated, restricting K+ passage until the AP repolarization phase begins. In addition to rapid onset and recovery from inactivation, hERG will also be inactivated very slowly. Therefore, even if the membrane potential returns to the resting potential, an outward K + current will flow. This strongly supports the effective repolarization of cardiac AP. At

Eusoft free webinar Nowadays everyone is talking about Business intelligence as the main solution to every kind of issue. In fact, this technology is really helpful if based on strong and certified data. The BI technology is first data reliability and also data analysis and advanced report. In the LIMS world this is even more important, as we talk about processes, tests, samples, results. These types of data should be managed in an appropriate way, in order to turn data in useful information and make decisions. This goal can be achieved with powerful tools, as the Business Intelligence technology. Also, BI is able to support trends analysis with the aim to improve internal processes and make conscious decisions. On Thursday 26th November 2020 at 15:00 GTM we are going to explore the world of the Business Intelligence and the benefits of a BI solution implemented in a LIMS. Don’t miss the webinar, sign up now.

Together for a green economy Friday, November 27 is "Black Friday". A day that many people see as the perfect moment for Christmas shopping due to high discounts. LabMakelaar also sees Black Friday as a dark day for the climate. Over-consumption has a major impact on the environment. In addition to the use of raw materials and the use of fossil fuels for production and worldwide transport, the mountain of waste is also increasing due to "bad bargain". And they are lurking even more during Black Friday because of these high discounts. To be able to do something back for our planet, at LabMakelaar it`s not Black Friday, but "Green Friday". We don`t give (extra) discounts on this day, but we give trees. For every € 250,- we generate in sales on Friday November 27, we plant a tree during the Dutch national tree day, March 17 2021*. You contribute to corporate social responsibility, we plant the trees. In this way we keep our earth green and healthy together. After all, only together you can realize

CD Genomics is a genomics service company with a good reputation for providing reliable microbial sampling products, microbial testing services, microbial genomics services, and integrated bioinformatics services. These days, the product manager of CD Genomics announced microecology and environment solutions to maintain the ecological balance of material circulation and decompose biological remains especially in extreme environments. Microorganism are the most important decomposer in the environment, which play an extremely important role in maintaining the ecological balance of material circulation and decomposing biological remains especially in extreme environments, such as maintaining ecosystem functions, directly participating in the biochemical circulation of carbon, nitrogen, sulfur, phosphorus and some metals, and accelerating the process of environmental pollution restoration. Microbes also play an important role when the environmental ecosystem responds to

Based on rich experience in targeted sequencing, CD Genomics has developed a specialized platform for targeted sequencing of disease-related genes to accelerate research on disease pathogenesis, disease identification, biomarker discovery, targeted drug development, etc. These days, the product manager of CD Genomics announced that the company has recently optimized inherited disease panels, which can help researchers detect genetic mutations more efficiently and accurately associated with a variety of genetic diseases. CD Genomics offers predesigend NGS panels, which include a designed library of targeted sequencing, as well as a custom panel that allows customers to select genes of interest to design their own sequencing panels. The targeted sequencing technology with targeted enrichment strategies can provide you with genetic disease screening. These services are pre-designed groups that help researchers more efficiently and accurately detect genetic mutations associated

Creative Enzymes, a professional and experienced supplier of probiotics, mainly provides enzyme-related products and services. With the continuous expansion of business areas and scale, they have set foot in other areas and established a sound probiotic production and supply chain. Based on high-quality products and services, as well as the unique advantages of large-scale production, its probiotic products are widely favored by industrial customers and scientific research customers. Probiotics are living microorganisms that co-exist with the human. Different from pathogenic microorganisms, probiotics are beneficial, sometimes essential to health. For example, the intake of probiotics can increase the number of beneficial bacteria in the intestine, maintain the dynamic balance of intestinal flora, and enhance gastrointestinal health. “Creative Enzymes has established a specialized production site for freeze-dried probiotics and provides custom probiotic formulation.

Internet of Things, automation and AI driving new levels of nutra manufacturing process control SIRIO – a leading nutraceutical contract development and manufacturing organisation (CDMO) – has completed a new ‘smart factory’ at its Ma’anshan site, with Internet of Things (IoT) enabled automated processes and monitoring, intelligent distribution robotics and Artificial intelligence (AI). Sirio is a first adopter of smart factory tech (industry 4.0) among nutraceuticals manufacturers, bringing a level of reporting, manufacturing control, production efficiency and automation not seen before. This empowers both the manufacturer and client with real-time production parameters, and machine learning for continual process optimisation, providing improved reproducibility and precision quality standards. Rui Yang, CSO at Sirio, commented: “Rather than build a conventional factory setup, we have taken a lead in the nutra industry to look ahead at how quality, manufacturing and logistics can be augmented by connected technologies. Our new smart factory, using IoT and AI,

With years of experience in the pharmaceutical and life science sector, Creative Diagnostics recently introduces a series of electroluminescent quantum dots for light-emitting diodes, which are ideal for large-panel displays because of their excellent efficiency, colour purity, reliability and cost- efficient fabrication. Quantum dot (QD) light-emitting diodes (LEDs) are fabricated using a QD film as an emitting layer (EML). When a direct-current voltage is applied, electrons and holes are injected into QDs to emit light. QD-LEDs enable the fabrication of thin, lightweight, and flexible displays with a wide color gamut and high image quality. Because QD-LEDs are suitable for manufacturing via the coating process, they are also expected to reduce the manufacturing cost for larger screens. A typical QD material is Cd-based QDs. Cd-based quantum-dot light-emitting diodes have been extensively explored for applications in display and lighting due to their unique merits

Virtual Expo Connect to empower access for international pharma to the world’s largest pharma ingredients mark Amsterdam, 16 November 2020: CPhI & P-MEC China returns as a hybrid event in Shanghai (16-18 December, 2020), with a physical exhibition running alongside Virtual Expo Connect (18 November – 18 December, 2020) for international audiences unable to attend. The physical exhibition will be held at the SNIEC (Shanghai New International Expo Center), with some 3,000 exhibitors present across three days, alongside exhibitor talks and conferences. Crucially, this year’s exhibition will support international attendees with a dedicated month-long digital platform, Virtual Expo Connect. Reacting to customer needs, CPhI & P-MEC China introduced a new hybrid model so that pharma executives (unable to visit Shanghai) can continue to meet and do business in the country – which plays such an integral role in global supply chains. In fact, China is the world’s biggest ingredients producer, supplying 80% of chemicals used in European drug manufacturing and 70% of APIs to Indian manufactures

Full pore size distribution of materials possible Norcross, GA, USA – November 10, 2020. Micromeritics Instrument Corp., the world’s leading supplier of high-performance systems to characterize particles, powders and porous materials, today highlighted its fully automated Micromeritics TriStar II Plus 3030 surface and porosity analyzer. Leveraging an advanced non-local density functional theory (NLDFT) model, the instrument enables users to combine the information gathered from nitrogen and carbon dioxide isotherms to deliver a full pore size distribution on materials such as carbon slit pores where pores of molecular sizes are present. The range of pore size analysis in this method is extended to smaller pore sizes compared to the standard nitrogen analysis. Using CO2 provides access to ultramicropores that are not accessible to N2 at cryogenic temperatures due to kinetic size restrictions, connectivity problems, or extremely slow diffusion. As a three-station unit the TriStar II Plus 3030 ensures a rapid and comprehensive

With the B-492 PCR tube label, up to 8 PCR tubes can be labelled simultaneously. Designed to resist a range of chemicals, and easily printable in any lab with a Brady label printer, the PCR tube label is precise, reliable and efficient. Save time Instead of labelling every PCR tube separately, up to 8 PCR tubes can be identified simultaneously. The B-492 PCR tube label contains 8 smaller, perforated labels in a single label strip. The self-adhesive strip can be applied on 8 PCR tube labels in a rack and can easily be torn after application into separate PCR tube labels thanks to the perforations. Reliable identification The B-492 PCR tube label is made out of polyester and will resist common lab chemicals, including DMSO, Xylene and Ethanol, as well as low and high temperatures. Its adhesive is designed to stick to curved PCR tubes so the label doesn`t fall off, even when stored in liquid nitrogen. When printed with a Brady label printer, the ink on the label will not smear or fade and will remain legible throughout processing to enable reliable

MoA Technology leverages CDD Vault cheminformatics system to manage high-throughput herbicide screening data Agritech companies developing new herbicides generate and analyse huge amounts of data. Data from high-throughput screens, chemical optimisation work, plant genomics, bioefficacy and crop safety testing must be combined to pick candidates for development. Later, promising candidates must pass stringent mammalian toxicology and environmental safety evaluations. Startup and virtual companies commonly outsource synthetic chemistry, field, glasshouse, physicochemical and regulatory studies to contract research organisations (CROs), which adds another layer of complexity to data management. Ultimately, outsourcing works best if CROs and other collaborators have access to secure two-way information flow without compromising IP, data security or data quality. MoA Technology, an agritech startup, has found CDD Vault – developed by Collaborative Drug Discovery – to be the ideal informatics infrastructure to manage a wide range of data, seamlessly integrating in-house workflows

CDD Vault will enable the Dutch biotech to share research results with partners in real time Nijmegen and San Francisco — October 8, 2020 — TropIQ Health Sciences, a biotechnology social enterprise with a dual purpose to provide enabling technologies and expertise in drug discovery as well as to develop new drugs for the treatment of tropical, infectious, and neglected diseases announced today that it has implemented CDD Vault for managing its discovery programs. Developed by Collaborative Drug Discovery, Inc., CDD Vault is an informatics software for managing and sharing chemistry and biological research data centrally in a secure way. TropIQ’s unique laboratory technology platform includes facilities for semi-automated cell culture, a vector lab for entomological experiments, state-of-the-art signal detection equipment and a very experienced team of scientists that works closely with research teams around the world. Using CDD Vault, TropIQ will store, archive, and manage all data generated by their laboratory including screening results as well as chemical

Tuesday, December 15 | 12pm ET | 5PM GMT | 6pm CEST In 2003, then Caltech Professor Raymond Deshaies co-founded Proteolix to develop a proteasome-inhibiting compound that would later lead to the billion-dollar cancer drug carfilzomib/Kyprolis®. The company was subsequently acquired by Onyx and then Amgen. In this webinar, Dr. Deshaies (now SVP of Global Research at Amgen) will share with Dr. Barry Bunin (CEO, Collaborative Drug Discovery) the story behind the discovery of Kyprolis, as well as discuss the latest developments in areas related to PROTACs and COVID-19 biology. It will be a rare opportunity to get direct insights from a high-profile drug discovery pioneer that you don`t want to miss. In addition, this will be the first chance for a sneak peak of CDD`s BioHarmony - a modern semantic drug data store that offers real-time data streams on thousands of drugs, including Kyprolis.

Every third grinder is shipped abroad. As of end of October 2020, 30 SG 1 soil grinders manufactured by Vibrotechnik were sold. Unique equipment for the preparation of soil samples has found demand not only in various regions of Russia, but also abroad: 7 grinders have been supplied to the Republic of Kazakhstan, 2 - to the Republic of South Africa, 1 - to the Republic of Belarus. In South Africa, SG 1 soil grinders were purchased by Department of Agriculture Western Cape and Northam Platinum ltd through our exclusive distributor, Mineral Innovative Technologies (Pty) Ltd. vibrotechnik.com +7 (812) 468-72-12

Now even more efficient with the Fritsch cyclones The Fritsch variable Speed Rotor Mill Pulverisette 14 classic line is the ideal mill for fast, effective comminution of soft to medium-hard, brittle and fibrous materials as well as temperature-sensitive samples – proven worldwide for the use in trace analysis. The motor speed can be varied between 6,000 and 20,000 rpm in increments of one-thousand – making it possible to adapt the mill to each specific application. An automatic speed compensation feature ensures an ideal adaptation of the grinding to the specific comminution behaviour of the sample. At the same time, reduces the fast, effective grinding through the efficient air routing inside the Pulverisette 14 classic line significantly the thermal strain on the sample. Efficient cooling The ingenious air routing of the Pulverisette 14 classic line ensures a constant airflow to cool the rotor, all motor components and the grinding material in the collecting vessel. At the same time, a large fan blows the cooling

A flexible, continuous monitoring solution Hazel Hawkins Memorial is a full service, not-for-profit hospital located in Hollister, CA. Founded in 1907, the hospital offers a full range of inpatient and outpatient services including: emergency services, stroke care, surgical services, radiology and diagnostic imaging services, laboratory services, palliative care, physical, speech and occupational therapy, respiratory care, and a birthing center. Frank Gee manages the facilities for the hospital’s main campus in Hollister and 15 outpatient clinics throughout San Benito County. In his role as the Director of Plant Operations and Engineering responsible for all facility maintenance operations, Mr. Gee oversees adherence to safety and engineering standards and compliance with applicable regulations, laws, and codes. In 2018 The Joint Commission (TJC), a US-based accrediting body that establishes and enforces standards to ensure the safety and quality of healthcare facilities, performed a site survey of Hazel

Testing Viscous Samples With ISFET Some laboratory technicians face difficulties with testing thick, aqueous based samples for pH. This is unfortunate and hereby we provide some tips. ISFET Technology: Sensor and Reference Electrode The principle of the pH ISFET (ion-sensitive field-effect transistor) technology is that when the Hydrogen (H+) activity changes, the current driven voltage will change and a different pH value is measured accordingly. To complete the electrical circuit, the ISFET sensor (also called the indicator electrode) needs a reference electrode. For any change in the analyte concentration, the potential of the reference electrode will remain virtually constant and so the change of potential will only be caused by the indicator electrode. The pH probes of Wellinq are equipped with these components and so the user only has to take care that both the sensor and the reference diaphragm are in the same sample. Moreover, Wellinq has a broad experience in the development and manufacture

EKF introduces kit for convenient & safe collection, transport & handling of samples including COVID-19 & flu EKF Diagnostics announces that it has launched a PrimeStore® MTM sample collection kit. This new kit enables convenient and safe collection, transportation and handling of pathogenic samples, including COVID-19 and influenza. Two kit configurations are now available: a postal sample kit ideal for home use and a multi-pack of sample kits suitable for on-site mass sampling. To meet growing demand for this sample collection device, EKF has increased its manufacturing capacity in the UK and mainland Europe. Pathogenic samples stored in the FDA-cleared, CE-IVD marked PrimeStore MTM novel viral transport media, including SARS-CoV-2, are inactivated within minutes of collection. This allows such samples to be transported safely through the postal system or via courier and complies with UN3373 packaging regulations. Furthermore, as samples are stable in PrimeStore MTM for seven days at ambient temperatures, this removes the need for all cold chain logistics during sample collection,

SPETEC® peristaltic pumps Modern tube pumps that operate on the principle of peristalsis are often fitted in a wide variety of devices and equipment, where they transport precise volumes of fluids. The specific expertise of the pump manufacturer means that many OEMs that produce devices for tasks such as chemical/analytical measurements, medical use, in the foodstuffs industry or generally for tasks involving precise metering, do not manufacture the pumps themselves. Instead, they order them as OEM products. The pump manufacturer is expected to supply peristaltic pumps that operate extremely consistently and without pulsation and that have a longer service life than that of the device in which they are fitted. This requires not only special manufacturing methods, but also constant adaptations to performance and size. Ultimately, such constant, ongoing development of peristaltic tube pumps also has to be geared to the various tubing materials. What are OEM tube pumps? This type of peristaltic

Hammer crusher HC 2x2 Vibrotechnik The Hammer crusher HC 2x2 is laboratory-class equipment designed to crush small batches of material with output up to 100 kg/hour. Characteristics HC 2x2 Loading door dimensions - 200 x 330 (mm) Rotor dimensions (Diameter x Length) - 250 x 150 (mm) Maximum initial material size - 20 (mm) Initial material particle size - 0.5–10 (mm) Maximum output 100 (kg/hour) Hardness of material crushed- Up to 4 Mohs units Rotor rpm 1,000–3,000 Electric motor power 1,5–3 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height) - 885 x 550 x 1,410 (mm) Weight - 120 (kg) Hammer material – tool steel AISI 1066

Hammer crusher HC 5X2 Vibrotechnik Hammer crusher HC 5x2 are industrial-class equipment used in busy laboratories or in small and medium-sized production facilities. Characteristics HC 5x2 Loading door dimensions - 260 x 490 (mm) Rotor dimensions (Diameter x Length) - 500 x 250 (mm) Maximum initial material size – 100 (mm) Initial material particle size - 2–25 (mm) Maximum output - 750 (kg/hour) Hardness of material crushed - Up to 5 Mohs units Rotor - 1,500 rpm Electric motor power - 11 (kW) Overall dimensions (Length x Width x Height) - 1560 x 805 x 1230 (mm) Weight - 580 (kg) 50 Hz supply voltage - 380 (V) Hammer material – tool steel AISI 1066

Hammer crusher HC 5X5 - Vibrotechnik Hammer crusher HC 5X5 are industrial-class equipment used in busy laboratories or in small and medium-sized production facilities. Equipment of the HC 5x5 with a support frame and receiving containers of various volumes depending on the process task. Characteristics HC 5x5 Loading door dimensions 220 x 495 (mm) Rotor dimensions (Diameter x Length) 500 x 500 (mm) Maximum initial material size 100 (mm) Initial material particle size 2–25 (mm) Maximum output 1500 (kg/hour) Electric motor power 22 (kW) Overall dimensions (Length x Width x Height) 1755 x 840 x 1185 (mm) Weight 750 (kg) Hardness of material crushed - Up to 5 Mohs units Rotor - 1,500 rpm Electric motor power - 11 (kW) 50 Hz supply voltage - 380 (V) Hammer material – tool steel AISI 1066

Riffle sample splitters RSS 5 Vibrotechnik Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications RSS 5 Riffle width - 5 (mm) Total volume of sample receivers 3х0,77/ 3х0,5 (dm)3 Number of riffles -20 Material feed size maximum 1,5 (mm), Overall dimensions (mm) (Length х Width х Height) - 247х161х223 Weight 3,5 (kg) Company infor

Riffle sample splitters RSS 10 Vibrotechnik Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications RSS 10 Riffle width 10 (mm) Total volume of sample receivers 3х1,2/ 3х0,78 (dm)3 Number of riffles 16 Material feed size maximum 3 (mm) Overall dimensions (Length х Width х Height) 247х218х223 (mm) Weight 4,8 (kg) Company information

Riffle sample splitters RSS 15 Vibrotechnik Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications RSS 15 Riffle width 15 (mm) Total volume of sample receivers 3х4,8/ 3х3,1(dm)3 Number of riffles 16 Material feed size maximum 5 (mm) Overall dimensions (Length х Width х Height) 434х299х343 (mm) Weight 13,3 (kg)

Riffle sample splitters RSS 20 Vibrotechnik Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications RSS 20 Riffle width 20 (mm) Total volume of sample receivers 3х9,6/ 3х6,3 (dm)3 Number of riffles 16 Material feed size maximum 6,5 (mm) Overall dimensions (Length х Width х Height) 522х403х403 (mm) Weight 18,7 (kg)

Riffle sample splitters RSS 25 Vibrotechnik Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications RSS 25 Riffle width 25 (mm) Total volume of sample receivers 3х17,5 / 3х12,5 (dm)3 Number of riffles 20 Material feed size maximum 8 (mm) Overall dimensions (Length х Width х Height) 600х546х403 (mm) Weight 27,5 (kg) Company infor

Riffle sample splitters RSS 37,5 Vibrotechnik Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications RSS 37,5 Riffle width 37,5 (mm) Total volume of sample receivers 3х17,5 / 3х12,5 (dm)3 Number of riffles 14 Material feed size maximum 12,5 (mm) Overall dimensions (Length х Width х Height) 600х546х403 (mm) Weight 26,5 (kg)

Riffle sample splitters RSS 50 Vibrotechnik Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications RSS 50 Riffle width 50 (mm) Total volume of sample receivers 3х17,5 / 3х12,5 (dm)3 Number of riffles 10 Material feed size maximum 16,5 (mm) Overall dimensions (Length х Width х Height) 600х546х403 (mm) Weight 26,5 (kg)

Shaker mixers sm 50.0 «Drum tumbler» Vibrotechnik The «Drum Tumbler» SM 50.0 shaker mixer is industrial-class equipment used in busy laboratories and small industrial facilities. Technical characteristics SM 50.0 Cup/drum volume 50 (dm3) Cup rotational speed 49 (rpm) 50 Hz supply voltage 380 (V) Electric motor power 0,75 (kW) Overall dimensions (Length x Width x Height) 1155х770х1000 (mm) Drum material Stainless steel Company information Vibrotechnik Vibrotechnik Vibrotechnik is the leading Russian developer and manufacturer of equipment for sample preparation. Our key field is the supplying of laboratories with: • Jaw crushers, • Vibrating cone crushers, • Double-roller crusher, • Disk grinders, • Vibrating grinders, • Soil grinder, • Hammer mills, • Cutting mills; • Sieve shakers, • Circular vibratory screeners, • Laboratory sieves, • Shaker mixers, • Sample dividers, and other laboratory equipment. Last update: 08-06-2020 Edit your listing Related feature articles Refer to an article More items Refer

CMO growth hampered by innovator approvals from mega cap pharma Amsterdam, 9 November 2020: The global contact services sector is benefiting from a switch towards COVID-19 manufacturing (vaccine and therapy) and clinical stage contracts, but mega-cap innovator drug approvals are reducing commercial demand according to the CPhI Annual Report contract services findings. Adam Bradbury, Analyst and Fiona Barry, Associate Editor at PharmSource GlobalData provided a holistic review of the trends, challenges and opportunities in the global contract manufacturing space. In his report contribution, Adam Bradbury highlighted that mega cap companies accounted for a particularly high percentage of NDA approvals in 2019 – but this trend is potentially detrimental to CMOs’ prospects in 2020 and beyond, as such companies with their own internal manufacturing capabilities have less need to outsource manufacturing work. However, there remain good opportunities for CDMOs in clinical trial manufacturing with a large pipeline of drugs and both mega

As a global leading supplier of of raw materials, antibodies, and reagents for bio-technology industry, Creative Diagnostics now introduces COVID-19 Antigen Lateral Flow Assay Development, including the SARS-CoV-2 nucleoprotein antibody pair for rapid COVID-19 antigen assays to equip healthcare workers for rapid COVID-19 antigen detection. Additionally, Creative Diagnostics also offers SARS-CoV-2 antigen extraction buffer tubes that can be used as packing supplies for SARS-CoV-2 antigen extraction. The global COVID-19 pandemic has created an urgent demand for accurate rapid point of care testing. Antigen-based assays are suitably inexpensive and can be rapidly mass-produced, but sufficiently accurate performance requires highly optimized antibodies and assay conditions. Creative Diagnostics team has tested hundreds of anti-nucleocapsid antibody pairs to recommend clients the best pair for further development of an LFA for SARS-CoV-2 Antigen. SARS-CoV-2 antigen extraction

As a leading manufacturer and supplier of various drug delivery products and services, CD Bioparticles now introduces customized Metal Organic Frameworks (MOFs) materials with various material formats and chemical composition to help researchers solve challenges they might meet, such as limited MOF options in the market for different applications, restricted surface area, and low production yield and low consistency. These MOFs can be possibly applied in drug delivery, gas and liquid adsorption, gas storage, catalysis, and sensing and detection. Free of tedious processing and formulation and limited facilities for large production yield with consistant quality control, researchers are now accessible to various materals at CD Bioparticles, like Iron-based MOFs, Zinc-Based MOFs, Cobalt-based MOFs, Nickel-based MOFs, Indium-based MOFs, and Titanium-based MOFs. With this new release of these MOFs materials, at CD Bioparticles researchers can gain a lot of benefits such

CRISPR/Cas9 gene editing tools are one of the most promising methods for advancing the treatment of genetic diseases including cancer, and this research field is making continuous progress. Now, in a new study, Dr. Sandra Rodríguez-Perales of the Spanish National Cancer Research Center (CNIO) and his research team have made new progress: using this technology to eliminate the so-called fusion gene, which guides the development of cancer therapies that specifically destroy tumors without affecting healthy cells in the future. Fusion genes are an abnormal result of incorrectly ligating DNA fragments from two different genes, which is an accidental event during cell division. If the cells cannot benefit from this error, they will die and the fusion gene will be eliminated. But when this error leads to reproductive or survival advantages, cells carrying this fusion gene will proliferate, and the fusion gene and the protein it encodes will trigger tumor formation. Rodríguez-Perales

Microbial cell surface display technology can redesign the cell surface with functional proteins and peptides to give cells some unique functions. By fusing with anchor proteins, foreign peptides or proteins are transported out of the cell and fixed on the cell surface, which is an effective solution to avoid material transfer restrictions, enzyme purification and enzyme instability. As the most commonly used prokaryotic and eukaryotic protein surface display system, bacterial and yeast surface display systems have been widely used in vaccines, biocatalysis, biosensors, biosorption and peptide library screening. In recent years, the microbial cell surface display technology has had a profound impact on the mutual recognition of protein molecules, the development of new vaccines and the treatment of tumors. With the development of surface display technology, surface display systems have expanded from phage display systems to other microbial cell display systems. Currently,

We take you with us on an exciting tour through our application technology laboratory in Idar-Oberstein Be our guest. Go on a virtual tour of discoveries and find out new things and many exciting facts about sample preparation and particle sizing. Explore our laboratory and get to know our instruments from all angles on the interactive 360°tour. What is the principle behind the ball mills? Why is it so easy to clean Fritsch cutting mills? Which processes are used to measure the shape and size of a particle and how exactly does this work? You can discover all this and much more during the tour. Experience our products live. Uncertainties continue to determine real working life. These are times when actual trade fairs are unthinkable and travelling also becomes problematic. Nevertheless, we do not want to forego the dialogue with you and simply present our new products online. With our virtual product presentation, you can experience our products for milling, sizing, sieving and dividing directly at your workplace. This is how it works. Simply fill out the form by briefly