News items March 2020

as one of COVID-19 solutions Precise Information About Helmet-Based Ventilation Helps Patients, Medical Staff and Decision Makers Amidst COVID-19 Crisis Helmet-based ventilation proved itself efficient in Italy, where the new coronavirus COVID-19 has hit the hardest so far. As various regions of the world gear towards the biggest pandemic spread, hospitals, investors and manufacturers need precise information related to this revolutionary method of non-invasive ventilation. March 27, 2020. As the COVID-19 virus is fast spreading throughout the world, the search for faster and more efficient solutions to help its victims is more important than ever. Most recently, more than 545,000 people have tested positive around the globe and 24,862 have died. These numbers are growing daily. Andrew Cuomo, the governor of New York, has stressed the extreme shortage of ventilators calling them “single greatest challenge.” To better address the problem of oxygen delivery and to reduce “the work of breathing”

High accuracy and low retention Ritter Robotic Tips are ideal for robotic systems. The pipette tips have a high accuracy and a low retention. Several quality controls in the manufacturing process have been done to guarantee the quality of each individual tip. The Robotic Tips are available in ‘Black Knights’ and ‘Clear Knights’. The tips are compatible with liquid-handling systems of the following brands: Hamilton, Tecan, Qiagen and Olympus. Ritter Medical now also offers new Tecan wide bore robotic tips. These pipette tips have been developed with a 50% wider opening which allows particularly viscous samples such as blood plasma to be pipetted carefully.

SHANGHAI, China, March 25, 2020 / B3C newswire / -- Sartorius, a leading international partner of life science research and the biopharmaceutical industry, has supported CanSino Biologics Inc. (“CanSinoBIO”) and Maj. Gen. Chen Wei’s team at the Institute of Bioengineering at the Academy of Military Medical Sciences (“Institute of Bioengineering”) in China in their development of the first vaccine candidate against the novel coronavirus SARS-CoV-2 to enter clinical trials. CanSinoBIO and the Institute of Bioengineering used Sartorius’ BIOSTAT® STR single-use bioreactor system for the upstream preparation of the recombinant vaccine, thus ensuring the rapid linear amplification of the adenovirus vector (Ad5-nCoV) and ultimately saving time during development. The BIOSTAT® STR single-use bioreactor system comes with updated BioPAT® toolbox for process monitoring, as well as Flexsafe® STR integrated, single-use bioprocess bags. It has been proven to be used for vaccine manufacturing

Are there any surplus GC/MS Systems dusting in your warehouse or in the corner of your laboratory? Currently Labrecycling is searching for GC/MS systems and is asking for your help. We search among other things: •Agilent 6890/5973 •Agilent 6890/5975 •Agilent 6890/5977 •Agilent 7890A/5975C •Agilent 7890/5977 •Thermo ™ TRACE™ DSQ II •Thermo ™ TRACE™ 1310/ISQ •Thermo Scientific™ ISQ 7000 •Thermo Scientific™ TRACE™ 1310-8000 •Shimadzu GCMS-QP2010 SE •Shimadzu versatile GC-2014 •Shimadzu GCMS-QP2020 Labrecycling recycles chromatographic instruments and has room to take over your equipment. Throwing away is a sin.

Do you need to expand your laboratory equipment, but you do not have the opportunity to buy? Or do you need a temporarily expansion of capacity? At LabMakelaar Benelux you can also rent laboratory equipment for a short or longer period. Whether it is equipment or furniture, LabMakelaar offers you an inexpensive way to temporarily expand your laboratory. LabMakelaar Benelux B.V. strives for a world with a strong circular economy, in which companies have easy access to a total solution for their laboratory furnishings and equipment with high-quality and recycled materials. LabMakelaar consists of 3 business divisions to offer an all-in concept for your laboratory; - LabMakelaar: for laboratory equipment and furniture - Laboratorium.shop: for glassware and disposables - LabForRent: for renting and renting out laboratory spaces Do you want to know what we can do for you? Please do not hesitate to contact us.

Introduction The base catalyzed production of Biodiesel is done by the transesterification of tri-glycerides to methyl esters out of oils by adding heat, methanol and catalyst (KOH). Oils, like recycled cooking oils (yellow grease), animal fat, rapeseed oil, palm oil, soy oil, canola and jatropha. Besides control of the incoming raw material on iodine value (AOCS approved, procedure Cd 1e_01), free fatty acids and moisture content, it is equally important to control the Biodiesel reaction and consequently to check the final properties of the commercial end product. Final control of the end product Biodiesel has to fulfil the requirements of ASTM D 6751 and EN-14214. Process control can be done for example before phase separation, before and after purification (settle tank and/or ion exchanger). The problem before phase separation is the high content of glycerine, which settled very quickly in the sample container. So a centrifuge preparation step is needed.

Universidad Loyola Andalucia to invest in Micromeritics gas adsorption and catalyst screening systems Norcross, GA, USA – 17 March 2020 Micromeritics Instrument Corp., a global leader in material characterization technologies, has extended its suite of complementary instruments for heterogeneous catalyst testing so customers can now readily select multiple systems that work efficiently together to accelerate catalyst development. The Micromeritics ASAP 2020 Plus, a research grade gas adsorption system, and the Micromeritics Microactivity Effi, a fully automated laboratory catalyst screening unit, are a popular and powerful combination. The ASAP 2020 Plus is used to quantify core characteristics of the active catalyst and support while the Effi enables efficient catalyst evaluation under process relevant conditions. Dr Manuel Antonio Díaz Pérez, from the Universidad Loyola Andalucia (Seville, Spain) is one of the most recent customers to invest in this dual instrument solution for efficient catalyst research. “When it came to setting-up our new laboratory I had no hesitation

Targeted Protein Degradation Platform New York, March 17, 2020—One of the world`s leading chemical vendors BOC Sciences announces to launch the Targeted Protein Degradation Platform in response to addressing customers` concerns in finding a cure for difficult diseases. "The idea is quite simple," says a senior scientist from BOC Sciences. "Researchers want to develop protein degraders that can break into ubiquitin-proteasome machinery to change the destiny of disease-causing proteins. Aiming at this, they design small molecules with two active ends: one that binds to the protein of interest and the other that binds to a protein called E3 ubiquitin ligase. These bifunctional molecules force a handshake between the ubiquitin and the protein, sending it to the trash. They will keep on to repeat the same process, and as a result, quickly depleting levels of the unwanted protein.” Ever since the initial design of proteolysis-targeting chimera (PROTAC) by Sakamoto et al. in 2001, this technology has been successfully

The New York-based chemical supplier BOC Sciences, also one of the active players in early drug discovery, recently announces to enhance its one-stop compound screening platform, which is efficient, economical and systematic, aiming to help scientists fulfill their screening needs arising from drug R&D projects. Having more than 200 bioassays of various disease models both in vitro and in vivo, the platform’s screening capacity is now enhanced and reaches almost 100,000 samples per day. Among them, over 100 are high-throughput screening (HTS) or high content screening (HCS) models. Screening activities are of particular importance in the endeavors either to define potential pharmacological targets or to identify novel targets of known bioactive natural products in their drug discovery projects. A good design of chemical compound libraries can help reduce screening costs and save time while reserving the chance to find as many valuable hits as possible. Compound screening

BOC Sciences, known as a trust-worthy supplier of inhibitors, metabolites, impurities, ADCs, pharmaceutical excipients, APIs and intermediates, recently announces the release of nucleosides for various research use. The nucleosides provided can be classified into three categories: fluorescent nucleosides, antimetabolic nucleosides, as well as cancer and proliferation marker nucleosides. Some are in stock and ready for use while others can be synthesized according to customer`s specific needs. Composed of a nucleic acid base and a sugar, nucleosides are the basic building blocks of nucleic acids (DNA and RNA), which play a significant role in genetic information expression. As to the difference form nucleosides, nucleotides can be interpreted as phosphorylated nucleosides. Nucleosides are commonly obtained in vitro through de novo synthesis pathways and decomposition of nucleic acid which is from diet. In addition, nucleotides are of particular importance for the replication

VIDA is a revolutionary data collection technology that tracks, records and stores instrument measurement resu It is possible that you can better meet regulatory and compliance standards with VIDA, to avoid costly fines and better manage the data in your lab. Available for trial in your lab, VIDA has been successfully used by Teesside University in a lab trial, reporting 100% accuracy on the scientific data collected. Developed in close consultation with lab managers worldwide, VIDA is a compact and handheld technology that connects to standalone lab equipment, whether new or legacy. VIDA has been designed to ensure a seamless flow of data throughout your lab, capturing results directly from studies to eliminate the loss of raw data, making research more accurate and recordings guaranteed. Electronic and paperless, VIDA eliminates the need for manual records and removes associated risks of human error. VIDA improves workflow as it allows employees to work on lab data instantly and securely, even if they’re not onsite which in turn can save lab time, the amount of staff needed,

Organizers have acted quickly to secure three new dates for events in Japan, Southeast Asia and North America Amsterdam, 17 March 2020: The CPhI Pharma portfolio confirms new exhibition dates for CPhI Japan, CPhI South East Asia and CPhI North America. Following a detailed review of attendee requirements and event feasibility, the organizers have moved quickly to secure new dates for three editions of the CPhI pharma series. CPhI South East Asia will now take place July 1-3, 2020 at the Challenger 2, IMPACT centre in Bangkok, Thailand, with CPhI Japan being held September 30th until October 2nd, 2020 at the Intex Osaka Exhibition Center in Osaka, Japan. CPhI has also taken the decision to proactively reschedule CPhI North America. The event will be moved to September 9-11, 2020 [moving from May 5-7] and hosted at the Pennsylvania Convention Centre in Philadelphia, USA. The new calendar will ensure the pharma community continues to have events to source, learn and network. Content and conference programmes are planned for each edition and updated agendas will be available shortly.

Priority Fast Tracking Reno, Nevada, USA and Bonaduz, Switzerland (March 17, 2020) – Today, Hamilton Company announces multiple automation-related initiatives to aid healthcare workers and researchers as they battle the coronavirus (COVID-19) pandemic. Two new automated assay ready workstations, based on the Company’s Microlab® STARletliquid handling workstation, facilitate rapid, high-throughput diagnostic and research-based testing of SARS-CoV-2, the coronavirus that causes the novel COVID-19. 1: The MagEx STARlet assay ready workstation enables high-throughput magnetic bead-based RNA extraction of biological samples 2: The PCR Prep STARlet assay ready workstation is pre-configured and qualified to automate high-throughput pre-PCR sample setup using the latest Centers for Disease Control and Prevention (CDC) protocols Both assay ready workstations are designed to work with any provider’s assay chemistry, including those intended for qualitative detection of the coronavirus. Once the

Available April 25 At Roche there is a severe shortage of MagNa Pure processing cartridges. BIOplastics is currently designing and developing an alternative. The cartridges will be available from April 25.

30 March 2020, 2:00 pm GMT Why do you need to adopt a LIMS in your laboratory? And what’s so special about Eusoft.Lab LIMS? We will talk about this in our first Webinar of the year, together with Camden Town Brewery, which has already chosen Eusoft.Lab SaaS LIMS for the integrated management of its laboratory processes. Agenda What is a LIMS? How a LIMS can enhance data quality How a LIMS can help save money Intangible benefits of a LIMS The must-have of a good LIMS Eusoft.Lab 10 SaaS LIMS LIMS case study: Camden Town Brewery Eusoft.Lab 10: live demo Speakers Sarah Westall – Eusoft Ltd and Jarno Crippa – Camden Town Brewery Estimated duration 60 minutes Date and time: 30 March 2020, 2:00 pm GMT

June 3 & 4, 2020 Lake Maggiore With the support of our speakers, sponsors and the Gran Hotel Dino, the 8th Edition of the Paperless Lab Academy Europe will be welcoming you at the Lake Maggiore by JUNE 3 & 4 2020. The great agenda build with so much care remains confirmed. Do not miss though leaders from multiple industries sharing with your their digital transformation project outcomes and lesson learns. Come and discover along the 15 interactive workshop what the future of the laboratory will be made of. Discover the complete 2020 Program Foster digital revolution in your laboratory

Accurate and user-friendly The new TQC Sheen Automatic cupping tester offers optimal conditions to define the resistance of paint, varnish or related products to cracking and/or detachment from a metal substrate by visual assessment. The instrument subjects the test specimen to gradual deformation by indentation. Accurate The new cupping tester complies to many international standards, including EN-ISO 1520 and DIN 53156. EN-ISO 1520 requires panels to be deformed slowly at a steady rate between 0.1 mm/s and 0.3 mm/s without interruption. Especially with thicker steel panels hand-operated testers not always allow an uninterrupted deformation. The deformation speed of the TQC Sheen Automatic cupping tester can be set from 0.01 – 0.6 mm/s on steel panels (max. panel thickness 0.8 mm), and even to 0.7 mm/s on aluminium panels (max. panel thickness 1.2 mm). Easy to operate The TQC Sheen Automatic cupping tester is equipped with Triple I® Navigation: Intelligent Illumination Interface. The interface

Due to the exponentially growing demand of Covid-19 detection tests, there is currently a severe shortage in consumables for the Roche platforms. 96 well plates for Roche Light Cycler® 480 systems BIOplastics offers a direct alternative to the original 96 well plates. The plates have been validated and provide excellent results. Both barcoded and non barcoded plates are in stock and can be shipped within 24 hours. Ordering information Non barcoded 96 well plate: B17489 Barcoded 96 well plate: BB17489L MagNa Pure 96 processing cartridges BIOplastics is currently designing and developing an alternative for these cartridges. We estimate that the cartridges will be available within approximately 8 weeks. If you wish more information, please contact us.

Are there any surplus ICP-MS/OES Systems dusting in your warehouse or in the corner of your laboratory? Currently Labrecycling is searching for ICP-MS/OES systems and is asking for your help. We search among other things: •Perkin Elmer •Agilent •Thermo Scientific •Spectro Labrecycling recycles chromatographic instruments and has room to take over your equipment. Throwing away is a sin. Make your warehouse clear and give your ICP-MS/OES systems a 2nd life.

Are there any surplus HPLC Systems dusting in your warehouse or in the corner of your laboratory? Currently Labrecycling is searching for HPLC systems and is asking for your help. We search among other things: •Agilent 1100, 1200, 1260 & 1290 •Shimadzu LC10, LC20, Nexera & Prominence •Thermo Ultimate 3000 & Accela •Waters Alliance 2695, e2695 & Acquity Labrecycling recycles chromatographic instruments and has room to take over your equipment. Throwing away is a sin. Make your warehouse clear and give your HPLC a 2nd life.

Combining a gas pycnometer and envelope density analyzer to measure critical parameters for solid dosage forms Norcross, GA, USA – 05 March 2020 Micromeritics Instrument Corp., a global leader in material characterization technology, is shining the spotlight on the value of its Micromeritics AccuPyc II pycnometer and Micromeritics GeoPyc envelope density analyzer bundle, an efficient, comprehensive solution for density measurement for the pharmaceutical industry. The AccuPyc II and GeoPyc both measure volume by pycnometry, a displacement technique, but using different media. Together they determine a range of density parameters for pharmaceutical powders, granules, compacted ribbons and tablets (coated or uncoated). These parameters characterize the performance of key processes such as tableting and roller compaction, and influence critical quality attributes such as hardness, disintegration and dissolution profile. Fast, automated and efficient the latest AccuPyc II model 1345 and GeoPyc 1365 can be used to measure solid dosage forms from R&D, through manufacturing, and into

AMBIENT / High temperature / SEMI-MICRO Gel permeation chromatography (GPC) is a type of size exclusion chromatography (SEC) that separates molecules according to their hydrodynamic volume which is related to their molecular weight. The separation is based strictly on the size of the sample in solution, and there should be no interaction with the stationary phase of the GPC column. Elution order in GPC is that of an “inverse-sieving” technique, large molecules access a smaller pore volume than smaller molecules resulting in larger molecules eluting from the GPC column prior to the smaller molecules. GPC can determine several important parameters. These include number average molecular weight (Mn), weight average molecular weight (Mw), Z weight average molecular weight (Mz), and the most fundamental characteristic of a polymer, its molecular weight distribution. These parameters are important, since they affect many of the characteristic physical properties of a polymer. Differences in these parameters can

(U)Hplc analysis of biomolecules High performance liquid chromatography (HPLC) and, increasingly, ultra-high performance liquid chromatography (UHPLC) are the analytical workhorses of the pharmaceutical industry. All stages of the product’s lifecycle, from early development until production and stability testing need chromatographic analysis to characterize and quantify target molecules. Today, biopharmaceuticals are the fastest growing product segment of the pharmaceuti- cal industry. A thorough characterization of therapeutic biomolecules is a key task for the successful submission of data for regulatory approvals of new drugs, no matter whether biologic, biosimilar or biobetter. Quality control needs effective analytical tools that allow fast determination of critical quality attributes of the various kinds of biopharmaceuticals, such as monoclonal antibodies (mAbs) and other therapeutic proteins. With new biophar- maceutical formats, such as bispecific mAbs, antibody fragments and antibody-drug-con-

Purification of biomolecules The purification and recovery of a biological target molecule out of a tissue, cell or fermentation broth - the so called downstream processing (DSP) - usually requires a combination of separation technologies. Bioprocess chromatography is the most important technique for this purpose. Today, biopharmaceuticals are the fastest growing product segment of the pharmaceutical industry. An effective and affordable purification of therapeutic biomolecules is key for the successful development and commercialization of new drugs, no matter whether biologic, biosimilar, or biobetter. With new biopharmaceutical formats, such as bispecific mAbs, antibody fragments and antibody-drug-conjugates (ADCs) in the pipeline, rapid development of DSP steps will become even more important. Toyopearl®, TSKgel®, and Ca++Pure-HA® process media are renowned for their quality, reliability, and productivity, and cover all modes of bioprocess chromatography, including affinity (AFC), ion exchange