News items May 2020

Earlier this month in May, 2020, Alfa Chemistry Testing Lab, a professional testing and analysis organization, announced to have released nano-products safety evaluation services for companies and agencies that are engaged with the development and application of nano-products. Nanomaterials exhibit unique physical and chemical properties in contrast with engineered materials. As more nanotechnology products have moved into the marketplace, especially in the public health-related areas such as food, cosmetics or drug, there is a growing need to assess the potential risks that exposure to nanomaterials might bring to human health and the environment. “Considering this, we decide to offer a wide range of safety evaluation services for nano-products at biological level, cellular level, molecular level and environmental level,” says a senior scientist from Alfa Chemistry Testing Lab. Characterization of nanomaterials Physical-chemical characterization of nanomaterials

Earlier this month in May, 2020, the world’s leading chemical supplier Alfa Chemistry announced that a total of close to 800 PEG linker products are now available for its customers worldwide, including acid PEG linkers, alkyl PEG linkers, amino PEG linkers, azido PEG linkers, benzyl PEG linkers, biotin PEG linkers, fmoc PEG linkers, NHBoc PEG linkers, NHS ester PEG linkers, t-butyl ester PEG linkers, Thp peg linkers, and other PEG Linkers. Polyethylene glycol (PEG) linkers are necessary for bioconjugation and pegylation. Due to their characteristics of water solubility, lack of toxicity, low immunogenicity, well defined chain lengths and molecular weights, PEG linkers are widely used in pharmaceutical and biotechnology applications. PEGylation is considered one of the most successful techniques to enhance the therapeutic and biotechnological potential of molecules, such as therapeutic peptides, proteins, small molecules, oligonucleotides, and antibodies. The PEG based

Recently founded, the New York-based company AI & Medicine is an expert in the field of AI-Powered drug discovery, personalized healthcare and various medical applications. Having launched a unique AI-aided drug discovery platform last month, this company grows quickly with concerted support from many talented researchers and scientists. It offers drug R & D solutions from the perspective of AI for medical institutions and pharmaceutical enterprises worldwide. AI is transforming the practice of medicine. Owing to its ability to identify meaningful relationships in raw data, AI can be used in multiple medical scenarios. For example, it helps doctors diagnose patients more accurately, make predictions about patients’ future health, and even recommend better treatments. It is quite fair to say that AI can be applied in nearly every field of medicine. AI & Medicine can help apply machine learning to solve the following four concrete problems: Drug Research and Development

The Corona crisis forces us to reflect. The likely long break in our society necessitates unprecedented interventions and changes. This situation may well be crucial for the transition to a circular economy. LabMakelaar Benelux B.V. has been committed to a circular economy for many years. With the purchase and sale of high-quality second-hand lab equipment, furniture and consumables, we help other companies to also promote the circular economy and to do business in a socially responsible manner. We do this with LabMakelaar.com and Laboratorium.shop. Since November last year we have also added LabForRent. LabForRent.nl is a platform that helps prevent the vacancy of valuable lab space and production facilities. In the Benelux there is a clear overcapacity. In the context of the circular economy, it is important that these vacant spaces are filled with start-ups, for example. Because of these three branches within LabMakelaar Benelux B.V. we can offer a total package

Are there any surplus LC-MS Systems dusting in your warehouse or in the corner of your laboratory? Currently Labrecycling is searching for LC-MS systems and is asking for your help. We search among other things: •Agilent 6420/ 6460/ 6470/ 6490 and 6495 •Shimadzu LC-MS 8040/ LC-MS 8050 •Thermo Q Exactive •Thermo TSQ Vantage •Waters Xevo G2 XS Qtof Labrecycling recycles chromatographic instruments and has room to take over your equipment. Throwing away is a sin. Make your warehouse clear and give your LC-MS a 2nd life.

Carfilzomib (marketed under the trade name Kyprolis, developed by Onyx Pharmaceuticals) is an anti-cancer drug acting as a selective proteasome inhibitor. Chemically, it is a tetrapeptide epoxyketone and an analog of epoxomicin. Carfilzomib is derived from epoxomicin, a natural product that was shown by the laboratory of Craig Crews at Yale University to inhibit the proteasome. The Crews laboratory subsequently invented a more specific derivative of epoxomicin named YU101, which was licensed to Proteolix, Inc. Scientists at Proteolix invented a new, distinct compound that had potential use as a drug in humans, known as carfilzomib. Proteolix advanced carfilzomib to multiple Phase 1 and 2 clinical trials, including a pivotal phase 2 clinical trial designed to seek accelerated approval. Clinical trials for carfilzomib continue under Onyx Pharmaceuticals, which acquired Proteolix in 2009. Carfilzomib covalently irreversibly binds to and inhibits the chymotrypsin-like

Type 2 diabetes is the most common form of diabetes. Semaglutide is an agonist of glucagon-like peptide-1 (GLP-1) receptor that is developed to treat type 2 diabetes. It reduces blood sugar via increasing the production of insulin. Biochempeg has developed and can supply some key intermediates of Semaglutide. Semaglutide(trade names: Rybelsus,Ozempic) is a medication for the treatment of type 2 diabetes. It was discovered in 2012, by a team of researchers at Novo Nordisk as a longer-acting alternative to liraglutide. It was given a brand name Ozempic. Clinical trials were started in 2015, and phase 3 was completed in 2016. Semaglutide acts like human glucagon-like peptide-1 (GLP-1) so that it increases insulin secretion, thereby increasing sugar metabolism. It is distributed as a metered subcutaneous injection in a prefilled pen. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week injection is sufficient.

CD Genomics Upgrades Cost-effective Genome Sequencing Services Related to DNA Research SHIRLEY, NY – May 23, 2020 - CD Genomics, an expert in transcriptomics and next generation sequencing company, announces the technical escalation of its sequencing services, The updated service ranges include three: plasmid DNA sequencing, bacterial genome sequencing and human genome sequence, which are based on some of the most powerful platforms in this field with unrivaled accuracy and sensitivity. Plasmids are thought to play an important evolutionary role in microbial communities which is important carriers for bacterial populations to rapidly adapt to changing environmental conditions. The genetic variation produced by the plasmids carried within the population ensures robustness to environmental changes. Plasmid-mediated gene transfer plays an important role not only in the mobilization and spread of antibiotic resistance genes, but also in the pathogenesis of pathogens and the transmission of pathogenic determinants. Despite their importance, technical barriers

Blog by Sandra Heeren-Köhler How to be agile in this time of (Covid-19) crisis, be creative and also know how to acquire new customers? On March 16 the Dutch RIVM guidelines came: “Work from home as much as possible”. The first week suddenly everything stopped. The planned visits to view different locations and to meet the managers suddenly were cancelled. Instead, calls come in from people looking for lab space for research on Covid-19. Our account manager for LabForRent, Sandra Heeren-Köhler, has written a blog about this new situations. You can read the blog on our website. LabForRent is part of LabMakelaar Benelux B.V.

Encouragingly, the industry might be 30% along its sustainability journey, but greater interoperability needed Paris, 18 May 2020: In an in-depth review of the market and having evaluated the collective developments from this year’s Pharmapack event, Gregor Anderson – MD of Pharmacentric Solutions – offers a positive appraisal of pharma’s drive towards sustainability. “I am really encouraged by the massive strides we have made this year. As an industry, we are no longer paying lip service to sustainability and wherein once there might have just been a single dedicated employee, there are now entire teams looking at improving methods and exploring life-cycle impact” commented Anderson. One of the big differences identified is the increased sharing across the industry and how actively involved the entire supply chain is in the discussion. Both the suppliers of packaging and devices are working more closely with big pharma and this is leading to accelerated development. The next stage is interoperability, as for the industry to be able to truly meet sustainability goals it will

Academy Webinar program Welcome to the new initiative of the Paperless Lab Academy® platform. We wanted to build on the momentum created during the congress editions and provide continuity along the year so that you could find interesting and stimulating information and discussions about transforming your Laboratory, Research and Quality processes. What you should expect to find Topics rank from basic to experts levels about scientific data management, lab informatics solutions, new concepts and methodologies, digital optimisation and strategies for mastering your data and extract the maximum insights from them. Presenters are users, experts and through leaders from diverse industries. The material offered here is a combination of Webinar organised by the Academy that also includes a list of webinars from our partners. Due to the Pandemic crisis, we had to postpone our 8th edition of the PLA congress to 2021 and were grateful to our sponsors who are supporting us to overcome the tragic

SPETEC® Clean-room workbench: Mini environment eliminates particles No matter whether it be the medical or pharmaceuticals industries or semiconductor fabrication, many sectors are attaching increasing importance to producing and manufacturing components in a clean, particle-free environment. The primary fields of application for the Spetec clean-room workbench or mini environment are in the optical, electronic and mechanical industries. The clean-room workbench can be tailored to meet customer needs and the required clean room class. In other words, the size, features and design of the workbench are adapted as required. As a rule, the unit is made from special aluminum profiles suitable for use in clean rooms. The side walls can be made from glass or acrylic glass, or the box can be surrounded by a strip curtain. A laminar flow module is then fitted at the top, which delivers class 5 clean room conditions inside the box. This corresponds to a mere 100 0.5 µm particles. Compared with an approximate particle count of 1 million per cubic

Today more than ever, with the Covid-19 putting millions of people into the “working from home” category, organizations should go to the cloud computing to be future ready. Therefore, the acquisition of a cloud-based LIMS can be a decisive factor in enabling laboratories to successfully tackle this unprecedented period. Eusoft.Lab LIMS is the latest generation web-based software for the management of the laboratory. Designed to satisfy the highest standards, Eusoft.Lab natively integrates features that support its use as a service (SaaS) on cloud computing platforms and integration with mobile devices such as smartphones and tablets. With Eusoft.Lab LIMS the laboratory can perform operations such as accepting samples, entering results or issuing test reports, immediately, from anywhere. This means that one can be connected to their colleagues all the time and maintain the workflows in their laboratories without being in the office. With Eusoft.Lab LIMS, as long as

Unbeatable priced and with a unique measuring range from 0.01 – 3800 microns Ideal for particle size analysis in production and quality control, research and development or for controlling manufacturing processes. With the completely revised Analysette 22 NeXT you choose according to your requirements: The Analysette 22 NeXT Micro with a measuring range of 0.05 – 1500 µm for all typical measurement tasks or the high-end instrument Analysette 22 NeXT Nano with an extra wide measuring range of 0.01 – 3800 µm for maximum precision and sensitivity for smallest particles with an additional detector system. Your advantage: Especially easy operation, short analysis times, reliably reproducible results and the recording of additional parameters such as temperature and pH value during wet dispersion. Only one laser for even faster measurement results The new generation Analysette 22 NeXT operates like every Fritsch laser Particle Sizer with the patented Reverse Fourier design which has established itself by now as a general standard. The Laser Particle

Manufacturer and supplier of paint test equipment TQC Sheen from Capelle aan den IJssel is now part of the Industrial Physics Inks & Coatings segment. The Industrial Physics Inks & Coatings segment offers instrumentation for the test, measurement and analyses of inks, coatings and general surface treatments. The products are used across many industries ranging from coating manufacturing, infrastructure and automotive to marine, beverage and canning and general production. Brands in this segment include TQC Sheen (coating test and measurement equipment), C&W Specialist Equipment (corrosion and climate test cabinets), Fibro system (measurement equipment for dynamic surface properties) and Sheen Instruments (viscosity measuring instruments). The Industrial Physics family of complementary brands was built through strategic acquisition to offer customers integrated solutions that scale globally, can be serviced locally and are always advancing technologically. “In the

Movement towards healthy lifestyles and preventative supplements the lasting behavioural change post COVID-19 11 May, 2020: SIRIO Europe (Ayanda) – the European headquarters of the SIRIO Group, a global nutraceutical contract development, innovation and manufacturing organization (CDiMO) – says considerable worldwide demand for immunity products has accelerated in recent months due coronavirus, but it is also likely to deliver a permanent ‘new norm’ of higher growth. “Already in Europe, we have seen a significant spike in the demand for immunity products across the main economies. In fact, recent weekly data from Euromonitor shows an increased purchasing of Vitamin C and Multivitamins by consumers, with unusual levels of stockouts present throughout Europe. While production and supply chains have been pretty robust during lockdowns, we have still seen large stock shortages. This is particularly surprising, as we are now approaching summer, which is not traditionally a peak period for these products. Anticipating a surge, we secured a very large inventory of ingredients to ensure

Empowering international and domestic buyers with an online platform to access the world’s second largest phar Shanghai, May 8 2020: CPhI and P-MEC China – co-organized by Informa Markets, Cccmhpie and Sinoexpo Informa Markets – will host a special Virtual Expo Connect in June (18-24, 2020). The new online platform is designed to facilitate ongoing and new business connections in an age of travel restrictions and work at home orders. The Virtual Expo Connect (VEC) will leverage livestreams and chats to host online exhibitor webinars, matchmaking tools, invited buyer meetings, conference sessions and even Virtual Factory Tours. Running for seven full days, the groundbreaking Expo will provide abundant opportunities to break through the challenges of international restrictions and facilitate unlimited connections among global pharmaceutical companies. “CPhI & P-MEC China will take place later this year in December, but we wanted to explore how we could innovate for our exhibitors and attendees and help them overcome some of the current barriers to doing business with international

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Vaisala unveils high-end industrial Indigo transmitter to enable world-class data and smart decisions Vaisala’s decades of success as the market’s most popular humidity transmitter manufacturer continues with the newly launched Indigo 520 Transmitter that combines the latest technology with outstanding new features. Capable of accommodating up to two probes simultaneously, the transmitter brings enhanced convenience, compatibility and continuous accuracy to even the harshest of industrial measurement environments. Vaisala, a global leader in weather, environmental, and industrial measurements, introduced today the new industrial level Vaisala Indigo 520 Transmitter, which has been designed to bring extensive benefits and ease of use to demanding industrial applications. “I am very excited to welcome the new Indigo 520 Transmitter to the modular Indigo product family. The Indigo compatible products are the premium choice for providing high-quality data from a multitude of industrial processes. The new transmitter has what it takes to perform even in the harshest and

Used in good condition Mettler Toledo XP6 Specifications & Description Capacity (mg): 6100 Capacity (g): 6.1 Readability (mg): 0.001 Repeatability (mg): 0.0008 Linearity (mg): 0.0004 Weighing Units: g Calibration Type: Internal Languages: English, German, French, Italian, Spanish, Russian, and Japanese Output: RS-232 RS-232 Interface: Yes Height (in): 4 Width (in): 4 Depth (in): 11 Description: Excellence Plus XP Micro Balance, 6.1g x 1Ug Visit our website or contact us to get more information.

Second postponement will provide improved confidence and market conditions for exhibitors and visitors Amsterdam, 4 May 2020: CPhI South East Asia – organised by Informa Markets –  has postponed its rescheduled event to November 4-6, 2020 to provide more time for positive business conditions to return and for global disruption to ease. “Moving the event to November will further mitigate the impact of ongoing travel restrictions and provide more time for normality and confidence to return to the market. Our aim is to deliver a better overall platform for exhibitors and visitors to engage. It was a difficult decision, but a vital one, to ensure both the safety and integrity of the event,” commented Silvia Forroova, Brand Director at Informa Markets. Informa Markets will continue to host the event at the Impact, Muang Thong, Thani and is reaching out to all participants with detailed information. “It’s a dynamic situation globally, but we have tried to maintain as much communication with attendees as possible and we would like to thank those who participate and support