News items June 2020

Earlier this year, Alfa Chemistry announced to have released a series of intermediates for API about flu treatment, including oseltamivir intermediates, zanamivir intermediates, and peramivir intermediates, for its valued customers both at home and abroad. The company is now one of the world’s leading chemical suppliers of building blocks, reagents, catalysts, reference materials, and research chemicals as well as chemistry-related analytical and laboratory services. Intermediate refers to material produced in the process of API in organic synthesis, which can only be turned into API by further molecular change or refinement. Intermediates can be separated or not separated. APIs (Active Pharmaceutical Ingredients) are active components of a drug product. And together with suitable excipients, the dosage form of a pharmaceutical is finally manufactured. Flu (influenza) is an easily spread respiratory tract infection caused by a virus. Each year Millions of people get

As an expert in the field of AI-Powered drug discovery, personalized healthcare and various medical applications, the New York-based company AI & Medicine recently announces to release biomarker discovery and targeted proteomics services for researchers worldwide. This move is made to meet the increasing demand for new biomarkers in most areas of pathology, especially within the field of cancer diagnostics. Disease biomarker is a molecule that indicates changes in the physiology of a cell under diseased state and hence can be used as a tool for diagnosis of diseases. During the past decades, biomarker discovery has been mainly focused on the following two basic styles: hypothesis-based or discovery-based. While biomarker identification through hypothesis-based methods is essentially a by-product of the ever-increasing mechanistic understanding of disease processes, the discovery-based approaches focus on identifying changes in the presence or relative abundance of molecular

In recent years, AI has been gradually applied in the medical field, especially in the diagnosis of diseases such as lung cancer. AI helps to improve the early diagnosis accuracy rate of lung cancer. Lung cancer is the most common malignant tumor in the world, with morbidity and mortality ranking first in malignant tumors, and has become a recognized killer of human health. The prognosis of lung cancer is closely related to the clinical stage. Due to the late appearance of symptoms and signs, most patients have metastasized at the first visit to the hospital, and the 5-year survival rate is only 16% due to the missed optimal surgery time. Therefore, clinical staff are constantly looking for newer and more sensitive imaging techniques suitable for lung cancer screening. In August 2002, the National Lung Screening Trial (NLST) led the launch of a randomized controlled clinical trial comparing lung cancer screening with low-dose spiral CT (LDCT) and ordinary chest X-rays,

PEG Linker Hydrophilic poly(ethylene glycol) or PEG-linkers are particularly attractive as a linker for conjugation. Water solubility, lack of toxicity; low immunogenicity and well defined chain lengths and molecular weights are specific characteristics of PEG moieties relevant to pharmaceutical applications. Hydrophilic linkers The link between the antibody and the cytotoxic agent plays a critical role in development of antibody-drug conjugates. The nature of the linker can significantly affect the potency, selectivity, and the pharmacokinetics of an antibody-drug conjugate. A common feature of numerous linkers used to prepare antibody-drug conjugates is their hydrophobicity – or their inability to dissolve in water.  In most cases, the average drug-to-antibody ratio (DAR) or the number of drug molecules per antibody does not exceed 3-4 drug molecules per antibody molecule.  Many of the problems seen with hydrophobic linkers can be overcome by sulfonate- or PEG-containing hydrophilic

RNA used to be considered just a molecule that passed information between genes and proteins. In fact, at the beginning of life, RNA is the only living molecule, which can store information and also has the function of an enzyme. It took millions of years of evolution and evolution to produce DNA and protein molecules. In addition to acting as a messenger (mRNA) for protein synthesis, RNA also has a very important regulatory function, such as non-transcribed RNA includes miRNA, siRNA, lncRNA, piwiRNA, etc. Among them, there are more than 400 miRNA molecules alone, regulating at least one-third of human genes. Since the discovery of the DNA double helix structure, scientists began research on the realization of "programmed" pharmaceuticals based on the genetic information contained in nucleic acids and the base pairing law. The earliest beginning of RNA drug research includes antisense nucleic acid (ASO), small interfering nucleic acid (siRNA), aptamer, aptamer, snRNA,

As we know, COVID-19 is a serious global infectious disease outbreak with nearly 8,470,000 cases and around 453,000 deaths worldwide. As a professional biotech company, Creative Enzymes has the core technology in enzyme modification and expression. During this pandemic, it releases enzyme products for coronavirus nucleic acid detection to help fight against the disease. The COVID-19 coronavirus disease is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. Common symptoms include fever, cough, and shortness of breath. Other symptoms may include muscle pain, sputum production, diarrhea, sore throat, loss of smell, and abdominal pain. The World Health Organization officially announced the outbreak of COVID-19 as a global pandemic in March this year. “As long as COVID-19 threatens any country, the entire world is at risk and therefore every effort must be made to avoid mistakes of the past by ensuring protection is extended to everyone on

CD Genomics Releases Kits and Reagents for Coronavirus Research to Aid in COVID-19 Response COVID-19 is a serious global infectious disease outbreak with nearly 6,800,000 cases and around 397,000 deaths worldwide. As a professional biotech company, CD Genomics` Kits and reagents are based on some of the most powerful platforms. During this pandemic, it releases Kits and reagents products for coronavirus detection and research to help fight against the disease. The COVID-19 coronavirus disease is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. Common symptoms include fever, cough, and shortness of breath. Other symptoms may include muscle pain, sputum production, diarrhea, sore throat, loss of smell, and abdominal pain. The World Health Organization officially announced the outbreak of COVID-19 as a global pandemic in March this year. “As long as COVID-19 threatens any country, the entire world is at risk and therefore every effort must be made to avoid mistakes of the past by ensuring protection is extended to everyone on

Boronic Acids What`s the boronic acid? A boronic acid is a compound related to boric acid in which one of the three hydroxyl groups is replaced by an alkyl or aryl group. As a compound containing a carbon–boron bond, members of this class thus belong to the larger class of organoboranes. What`s the function about boronic acid? Boronic acids act as Lewis acids. Their unique feature is that they are capable of forming reversible covalent complexes with sugars, amino acids, hydroxamic acids, etc. (molecules with vicinal, (1,2) or occasionally (1,3) substituted Lewis base donors (alcohol, amine, carboxylate)). The boronic acid functional group is reputed to have low inherent toxicity. This is one of the reasons for the popularity of the Suzuki coupling in the development and synthesis of pharmaceutical agents. However, a significant fraction of commonly used boronic acids and their derivatives were recently found to gives a positive Ames test and act as chemical mutagens (The mechanism

Convenient – Precise - Reliable The Fritsch sieve range is the focused answer to all typical sieving tasks in the laboratory: three well-conceived instruments for every application, with Fritsch concepts that make the work simpler and faster – easy to operate, reliable and long-lasting. FRITSCH sieve Shakers are ideal for - Dry, wet and micro-precision sieving - Measuring the quantitative particle size distribution of solids and suspensions - Separating and fractioning - Simple, ergonomic operation - Fast, reproducible results - Sample quantities between 0.05 g and 15 kg - Sieve diameter from 100 mm to 450 mm, mesh widths from 5 μm – 125 mm - Can be used as testing equipment in accordance with Din en iso 9001 - Automatic sieve evaluation with the Fritsch software Autosieve Vibratory Sieve Shaker Analysette 3 PRO – precise sieving with amplitude control The high performance Vibratory Sieve Shaker Analysette 3 PRO offers everything you need for fast determination of quantitative particle size

Starting from last year, the professional analytical testing organization Alfa Chemistry Testing Lab has been adding resources to its website regarding rules and regulations on the broad spectrum of testing and analysis for companies and agencies in the industry. As an expert in testing and analysis, Alfa Chemistry Testing Lab has an experienced technical team that uses advanced analytical equipment and technology to meet the needs of different customers in a wide range of areas, including environment, food, material, agriculture and crop, personal care & beauty, healthcare, fine chemical products, stationery & office supplies, building products, household & apparel, nano products and more. While conducting analytical testing for any sample material, the most important goal is make sure that the constituents are in compliance with relevant industry standards, thus safe for consumers once entering the market. FDA, industry associations and other regulatory bodies have

On April 21, 2020, AI & Medicine proudly announced that it has successfully developed a unique artificial intelligence (AI) drug discovery platform, offering drug research and development solutions for medical institutions and pharmaceutical enterprises worldwide. Drug R&D is a very complicated, costly and time-consuming attempt. But with the advent of AI, this process can be simplified and more quickly paced. Through big data analysis and other technical means, this AI-powered drug discovery platform can quickly and accurately mine data and select the appropriate lead compounds. Compared with traditional methods, AI & Medicine can help customers save the cost of screening candidates by tens of billions every year. This AI platform can be widely used in various scenarios regarding drug development, and some are listed below. Drug Target Discovery Through Natural Language Processing (NLP) and based on a large number of medical literature and relevant data, this platform

The requirements in respect of cleanliness of laboratory environments have increased dramatically, particularly in the areas of industrial production, packaging and in analytical laboratories and research. A particulate-free, sterile environment is often crucial in such fields. For this reason, considerable amounts of money are often spent and enormous technical and building effort are invested in order to erect large clean rooms even though the cleanliness and purity required for the given application is only actually needed in certain areas of the laboratory. In particular, the requirements for cleanliness getting more important in analytical laboratories in particular, because the sensitivity of analytical instruments has undergone continuously significant improvement, so that it is no longer the analytical system alone that constrains the achievable detection limit, but also the purity of the chemicals and equipment used, such as pipettes and solvents. It is a fact

AFP Web Store Analytical Flow Products recently introduced a new website after its acquisition by the APN Global Group. We added to our web site a brand new platform, our web store. We at AFP thought that this would bring a new breeze on how to get analytical supply into your laboratories and into the field in a more rapid and efficient way. In these tough times, we are all facing with all travels put on hold we thought it would be a good idea to help the analytical world by creating a market place where everybody can find what he need and get a purchase done in few clicks. We put in this web store all the popular products i.e. our sampling and switching diaphragm (ELDV-SERIES) and rotary valves (MRV-SERIES). We included all necessary accessories like pneumatic and electrical actuator, and all their spare parts like replacement diaphragm / rotor and their respective tool kit. We also added our best sampling valve system available on the market, our DV-SERIES, which is a diaphragm-based

LabMakelaar Benelux B.V. strives for a world with a strong circular economy, in which companies have easy access to a total solution for their laboratory furnishings and equipment with high-quality and recycled materials. LabMakelaar offers a wide range of second-hand laboratory equipment, furniture and general laboratory supplies on its website. These have been purchased directly by us, we have on consignment or we offer them at our sales platform. We are always looking for second-hand and high-quality material. Do you have laboratory equipment and / or furniture that is no longer used by you? Please contact us to discuss the possibilities to sell.

As of January 1st this year, we have taken over our neighbors` premises. Due to the expansion with this building, we have almost doubled the surface of our warehouse. In the meantime, we have fully commissioned the new warehouse and our expedition has also moved to the new warehouse. The address for our logistics operations has changed with effect from 01-06-2020. If you come to drop off or pick up something, you can now go to Noordelijke Dwarsweg 51-A, 2761 GD in Zevenhuizen (ZH), The Netherlands. The visiting address for our office remains unchanged, Knibbelweg 18-C, 2761 JE in Zevenhuizen (ZH), The Netherlands. Of course you are welcome to come and have a look yourself. We ask that you take into account the Corona measures we have taken and follow our staff`s instructions each time you visit our company.

EU GMP Annex 1 revision triggers growing requirement to protect agar plates and prevent spoiled samples Cherwell Laboratories has increased the breadth of its range of stainless-steel prepared media accessories for use within cleanroom environmental monitoring (EM) programmes, in response to customer demand. This is due to the increasing importance and need for continuous microbial monitoring in line with updated GMP regulations for the manufacture of sterile medicinal products. The GMP regulatory inspectorate’s focus on the revised Eu gmp annex 1 - continuous viable monitoring and data integrity - has elevated the humble agar settle plate and active air sample plate to delivering very high value data points. The agar plate costs only pence, but as soon as it is allocated a time and location its loss or damage can delay batch release of sterile products and require expensive, time-consuming investigations. Andrew Barrow, Sales Manager, Cherwell Laboratories, explains, “Due to the recent Annex 1 revisions, we have seen a renewed and growing interest in simple, well designed

Patented PrimeStore® MTM sample collection device deactivates samples for safe sample handling and transport EKF Diagnostics has secured new contracts for the manufacture and supply of a novel, patented sample collection device which allows COVID-19 samples to be rapidly inactivated in the collection tube, avoiding contamination and preserving RNA without need for refrigeration. To support the increase in COVID-19 testing globally, a safe and easy sample collection and transport mechanism is essential, this is provided by the PrimeStore® MTM sample collection device. EKF is a contract manufacturer and supplier for the PrimeStore MTM, which is an FDA-cleared and CE-marked microbial nucleic acid storage and stabilization device, owned and created by Longhorn Vaccines and Diagnostics LLC (Bethesda, Maryland, US). PrimeStore MTM deactivates viruses, bacteria, fungi and mycobacterium tuberculosis allowing safe sample handling and transport, and eliminating the risk of infection during transport and in laboratories. In addition to removing the need for cold chain storage of samples,

MENA pharmaceutical sales expected to increase 24% from US$35.5 billion in 2019 to US$44.1 billion by 2023 Abu Dhabi, United Arab Emirates, 10th June 2020: Informa, the organisers of the leading regional pharmaceutical event CPhI Middle East & Africa, has announced that due to the COVID-19 pandemic, the 2020 edition of the show, scheduled to take place in September in Abu Dhabi, has been cancelled. A new earlier date and location for the event has been disclosed, with the show debuting in Riyadh, Saudi Arabia on March 2021. CPhI Middle East & Africa 2021 will be held at a time when the MENA pharmaceutical market is experiencing exponential growth. According to Fitch Solutions’ Q1 2020 MENA Pharmaceutical & Healthcare Report, MENA pharmaceutical sales are expected to increase by over 24% from US$35.5 billion in 2019 to US$44.1 billion by 2023 – primarily a result of the region’s chronic diseases, particularly cancer, diabetes, and cardiovascular diseases. Sherma Ellis, Brand Manager, CPhI Middle East & Africa, said: “Maintaining the health and safety of all employees,

Jaw crusher JC 6M is designed for crushing small samples of material in laboratories with low and medium workloads. The small size, low weight and electric motor power make it possible to use the JC 6M in mobile laboratories, in low-capacity process installations and in geological surveying. Characteristics JC 6М Loading door dimensions - 60х100 (mm) Maximum initial material grain size - 50 (mm) Discharge slot adjustment range - 2-25 (mm) Maximum output - 200 (kg/hour) Collecting container / tank volume - 2 / 10 (L) Electric motor power - 1,1 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height / with stand) - 645х340х610 / 1100 (mm) Weight / with stand - 135 / 165 (kg) Jaw material – iron / steel / wolfram carbide - GJN-HV600 (XCr14) / UNS J91109 / WC

Jaw crusher JC 10М is a more powerful model of the laboratory-class equipment, used for continuous crushing of material in small and medium-sized facilities. When it is equipped with a support stand with a collecting container, it can be used for intermittent crushing of samples. Characteristics JC 10M Loading door dimensions - 100х200 (mm) Maximum initial material grain size – 70 (mm) Discharge slot adjustment range - 3-25 (mm) Average product particle size at minimum aperture - 90% 2,5 (mm) Maximum output - 500 (kg/hour) Collecting container / tank volume 20 (L) Electric motor power 2,2 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height / with stand) - 710х490х620 / 1090 (mm) Weight / with stand -285 / 325 (kg) Jaw material – iron / steel / wolfram carbide - GJN-HV600 (XCr14) / UNS J91109

Jaw crusher JC 15 is a high-power model designed for busy laboratories or small production facilities. The increased wall thickness, 5.5 kW electric motor and durable bearings make it possible to operate the JC 15 continuously with minimal process interruptions. Characteristics JC 15 Loading door dimensions - 150х250 (mm) Maximum initial material grain size - 110 (mm) Discharge slot adjustment range - 1-25 (mm) Average product particle size at minimum aperture 90% 1 (mm) Maximum output 1000 (kg/hour) Collecting container / tank volume 15 (L) Electric motor power 5,5 (kW) 50 Hz supply voltage 380 (V) Overall dimensions (Length x Width x Height / with stand) 1000х570х960 (mm) Weight / with stand 515 (kg) Jaw material – iron / steel / wolfram carbide - GJN-HV600 (XCr14) / UNS J91109

The jaw crushers are designed to crush brittle bulk materials of various strength and hardness. In the jaw crushers, the material particles are broken down by the compressive and shear strains between the fixed and moving jaws. The grain size of the crushed material is determined by the gap between the jaws in the lower part (the discharge slot) and the physical properties of the material. Characteristics JC 10 Loading door dimensions - 100х200 (mm) Maximum initial material grain size - 70 (mm) Discharge slot adjustment range - 3-25 (mm) Average product particle size at minimum aperture -90% 2,5 (mm) Maximum output - 500 (kg/hour) Collecting container / tank volume - 20 (L) Electric motor power - 2,2 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height / with stand) - 720х475х630 / 1105 (mm) Weight / with stand - 275 / 315 (kg) Jaw material – iron / steel / wolfram carbide - GJN-HV600 (XCr14) / UNS J91109

The jaw crushers are designed to crush brittle bulk materials of various strength and hardness. In the jaw crushers, the material particles are broken down by the compressive and shear strains between the fixed and moving jaws. The grain size of the crushed material is determined by the gap between the jaws in the lower part (the discharge slot) and the physical properties of the material. Characteristics JC 6 Loading door dimensions - 60х100 (mm) Maximum initial material grain size - 50 (mm) Discharge slot adjustment range - 2-25 (mm) Average product particle size at minimum aperture - 90% 2 (mm) Maximum output - 200 (kg/hour) Collecting container / tank volume - 2 / 10 (L) Electric motor power - 1,1 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height / with stand) - 640х340х600 / 1090 (mm) Weight / with stand - 130 / 160 (kg) Jaw material – iron / steel / wolfram carbide - GJN-HV600 (XCr14) / UNS J91109 / WC

The CM 120 cutting mill is laboratory-class equipment designed for comminuting small batches of material with grain size up to 20 mm. The CM 120 effectively comminutes fiber materials by crushing them with a plunger through a vertical shaft. Characteristics CM 120 Loading door dimensions 125х190/ 60х60 (mm) Rotor dimensions (Length x Diameter) 80 х 120 (mm) Maximum size of comminuted material 20 (mm) Product particle size 90% 0,5 (mm) Rotor rotational speed 1,500 (rpm) Electric motor power 1,5/1,1 (kW) 50 Hz supply voltage 220/380 (V) Overall dimensions (Length x Width x Height) 850х550х1185 (mm) Weight 46 (kg) Blade material – tool steel - AISI 01, DIN 150Cr14, AISI 5135

The CM 250 cutting mill is high-power equipment designed for busy laboratories or small production facilities. Characteristics CM 250 Loading door dimensions 250х510 (mm) Rotor dimensions (Length x Diameter) 250 х 250 (mm) Maximum size of comminuted material 100 (mm) Product particle size 90% 2,0 (mm) Rotor rotational speed 1,000 (rpm) Electric motor power 7,5 (kW) 50 Hz supply voltage 380 (V) Overall dimensions (Length x Width x Height) 1525х585х1465 (mm) Weight 460 (kg) Blade material – tool steel - AISI 01, DIN 150Cr14, AISI 5135

Cutting mills are designed to comminute fiber, polymer and plant materials. In cutting mills, comminution occurs by means of cutting – shear strains of material particles between rotor blades and a housing. The grain size of the comminuted product is regulated by the openings in the discharge grate and the physical properties of the material. Characteristics CM 120M Loading door dimensions 200х60/60х60 (mm) Rotor dimensions (Length x Diameter) 80 х 120 (mm) Maximum size of comminuted material 20 (mm) Product particle size 90% 0,5 (mm) Rotor rotational speed 1,500 (rpm) Electric motor power 1,5/1,1 (kW) 50 Hz supply voltage 220/380 (V) Overall dimensions (Length x Width x Height) 500х380х685 (mm) Weight 48 (kg) Blade material – tool steel - AISI 01, DIN 150Cr14, AISI 5135

The Hammer mill HM 2x2 is laboratory-class equipment designed to crush small batches of material with output up to 100 kg/hour. Characteristics HM 2x2 Loading door dimensions - 200 x 330 (mm) Rotor dimensions (Diameter x Length) - 250 x 150 (mm) Maximum initial material size - 20 (mm) Initial material particle size - 0.5–10 (mm) Maximum output 100 (kg/hour) Hardness of material crushed- Up to 4 Mohs units Rotor rpm 1,000–3,000 Electric motor power 1,5–3 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height) - 885 x 550 x 1,410 (mm) Weight - 120 (kg) Hammer material – tool steel AISI 1066

Hammer mills HM 5x2 are industrial-class equipment used in busy laboratories or in small and medium-sized production facilities. Characteristics HM 5x2 Loading door dimensions - 260 x 490 (mm) Rotor dimensions (Diameter x Length) - 500 x 250 (mm) Maximum initial material size – 100 (mm) Initial material particle size - 2–25 (mm) Maximum output - 750 (kg/hour) Hardness of material crushed - Up to 5 Mohs units Rotor - 1,500 rpm Electric motor power - 11 (kW) Overall dimensions (Length x Width x Height) - 1560 x 805 x 1230 (mm) Weight - 580 (kg) 50 Hz supply voltage - 380 (V) Hammer material – tool steel AISI 1066

Hammer mills HM 5x5 are industrial-class equipment used in busy laboratories or in small and medium-sized production facilities. Equipment of the HM 5x5 with a support frame and receiving containers of various volumes depending on the process task. Characteristics HM 5x5 Loading door dimensions 220 x 495 (mm) Rotor dimensions (Diameter x Length) 500 x 500 (mm) Maximum initial material size 100 (mm) Initial material particle size 2–25 (mm) Maximum output 1500 (kg/hour) Electric motor power 22 (kW) Overall dimensions (Length x Width x Height) 1755 x 840 x 1185 (mm) Weight 750 (kg) Hardness of material crushed - Up to 5 Mohs units Rotor - 1,500 rpm Electric motor power - 11 (kW) 50 Hz supply voltage - 380 (V) Hammer material – tool steel AISI 1066

The Roller crusher with smooth rollers DRC 200х125 is designed to crush brittle materials of various strengths. The operational principle of the roller crusher is based on simultaneous compressive and shear strains between rollers rotating in opposite directions. Characteristics DRC 200х125 Charging door dimensions 160 х 200 (mm) Roller diameter 200 (mm) Roller length 125 (mm) Maximum material feed size 16 (mm) Distance between rollers 0–12 (mm) Average crushed product particle size at minimum aperture 90% 0,25 (mm) Maximum output 700 (kg/hour) Hardness of material crushed Up to 7 Mohs units Electric motor power 2 х 1,1 (kW) Roller rpm 650 and 670 50 Hz supply voltage 380 (V) Overall dimensions (Length х Width х Height) - 680 х 400 х 950 (mm) Weight 245 (kg) Roller material: tool steel - AISI 1066, AISI 01, DIN 150Cr14

The SG 1 soil grinder is designed to grind dry soil samples without comminuting plant inclusions and stones. Soil comminution in the grinder occurs as result of material particles being crushed by rollers. The grain size of the comminuted product is regulated by the size of the discharge grating openings and depends on the physical properties of the material. Characteristics sg 1 Loading door dimensions - 145 х 140 (mm) Roller dimensions (Diameter x Width) - 55 х 28 (mm) Number of smooth/toothed rollers 4/4 Maximum initial material grain size - 20 (mm) Size of discharge grate openings - 1 and 2 (mm)* Average comminuted product particle size with grate with 1 mm opening -1 (mm) Maximum output – 40 (kg/hour) Gear motor power -0.75 (kW) Shaft rotational speed -75 (rpm) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height) - 638 х 440 х 690 (mm) Weight -58 (kg) Roller material – tool steel AISI 1066, AISI 01, DIN 150Cr14 *

The Disc grinder DG 65 is designed for comminution of small samples weighing up to 1.0 kg for analytical studies with strict requirements relating to sample purity: the sample is not contaminated by working parts of the grinder. Characteristics DG 65 Disc diameter - 65 (mm) Width, Area of parallel zone of discs -5 mm / 10 cm2 Maximum initial particle size - 3 (mm)* Average crushed product particle size at minimum aperture - 0,05 (mm) Maximum hardness of comminuted material - 8 units (Mohs units) Maximum output - 5 (kg/hour) Electric motor power -0,37 (kW) 50 Hz supply voltage -220 (V) Overall dimensions (Length x Width x Height) - 350х225х300 (mm) Weight -21 (kg) Disc material - SiC *The maximum allowable size of the initial material depends on its physical properties.

The Disc grinder is high-power equipment designed for busy laboratories or small production facilities. Characteristics DG 175М Disc diameter - 175 (mm) Width, Area of parallel zone of discs 29 mm / 130 cm2 Maximum initial particle size - 10 (mm)* Average crushed product particle size at minimum aperture - 0,071 (mm) Maximum hardness of comminuted material - 8 units** (Mohs units) Maximum output - 50 (kg/hour) Electric motor power - 2,2 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height) - 625х375х485 (mm) Weight – 83 (kg) Disc material - GJN-HV600(XCr14) / UNS J91109 with tungsten carbide inserts ** The maximum allowable size of the initial material depends on its physical properties. **If discs with tungsten carbide inserts are used.

Pharmapack Europe experts to explore how AI is delivering step change improvement in manufacturing & packaging Paris, 08 June 2020: In the absence of ‘in person’ meetings, access to deep dive pharma insights are not on hold, and later this month experts will discuss how AI is rapidly evolving supply chain dynamics in a ground-breaking Pharmapack Europe webinar (June 17, 2020). Veronica Ghidotti, Product Manager at Antares Vision; Aurelio Arias, Engagement Manager at IQVIA; and Luca Antiga, CTO and co-founder at Orobix, will provide a précis of current manufacturing and packaging technologies and explore how future AI can expedite processes and improve supply chain transparency. The webinar will seek to take a forward-looking perspective on how to integrate AI into workflows, the challenges of implementing AI projects in healthcare, and the advantages of using real-time analytics on performance enhancement and waste reduction. This window into tomorrow’s technology will afford manufacturers vital insights today on an emerging area that will have far reaching consequences

The Disc grinder DG 200 is a more powerful model of the laboratory-class equipment. It can be used for comminution of small samples weighing up to 3 kg, as well as for continuous comminution, by outfitting it with 1.8L or 10L receiving containers, as well as Feeders PG 1 or PG 2. Characteristics DG 200 Disc diameter - 200 (mm) Width, Area of parallel zone of discs - 42 mm / 200 cm2 Maximum initial particle size - 15 (mm)* Average crushed product particle size at minimum aperture -0,1 (mm) Maximum hardness of comminuted material - 8 units** (Mohs units) Maximum output - 150 (kg/hour) Electric motor power -2,2 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height) - 630х410х925 (mm) Weight - 135 (kg) Disc material - GJN-HV600(XCr14) / UNS J91109 with tungsten carbide inserts ** The maximum allowable size of the initial material depends on its physical properties. **If discs with tungsten carbide inserts are used.

The Disc grinder DG 250 is high-power equipment designed for busy laboratories or small production facilities. Characteristics DG 250 Disc diameter - 250 (mm) Width, Area of parallel zone of discs - 62 mm / 370 cm2 Maximum initial particle size 15 (mm)* Average crushed product particle size at minimum aperture 0,1 (mm) Maximum hardness of comminuted material - 7 units (Mohs units) Maximum output - 300 (kg/hour) Electric motor power - 4 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length x Width x Height) 930х410х935 (mm) Weight - 160 (kg) Disc material - GJN-HV600(XCr14) / UNS J91109 ** The maximum allowable size of the initial material depends on its physical properties. **If discs with tungsten carbide inserts are used.

Vibrating grinders are designed to comminute samples to a finely dispersed state in intermittent operation. The VG 1 vibrating grinder is designed for comminution in intermittent operation of one sample with volume from 20 to 50 cm3. Characteristics VG 1 Cup charging volume -20–50 (cm3) Number of cups - 1 Maximum material feed size - 5 (mm) Vibration frequency 1,500 (vibrations / minute) Vibration amplitude -3,5 (mm) Comminution time 1–30 (minutes) Maximum material hardness 8 Mohs units Electric motor power - 0,37 (kW) 50 Hz supply voltage 380 (V) Overall dimensions (Length х Width х Height) 509х395х310 (mm) Weight 54 (kg) Grinding element material – tool steel / zirconium dioxide / wolfram carbide - AISI 01, DIN 150Cr14 / ZrO2

Vibrating grinders are designed to comminute samples to a finely dispersed state in intermittent operation. Vibrating grinder VG 3M is designed for simultaneous grinding of three samples with a volume from 20 to 50 cm³. Characteristics VG 3M Cup charging volume - 20-50 (cm3) Number of cups - 3 Maximum material feed size - 5 (mm) Vibration frequency - 1,500 (vibrations / minute) Vibration amplitude - 10 (mm) Comminution time - 1–30 (minutes) Maximum material hardness - 8 Mohs units Electric motor power -2,2 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length х Width х Height) - 670х615х1225 (mm) Weight - 230 (kg) Grinding element material – tool steel / zirconium dioxide / wolfram carbide -AISI 01, DIN 150Cr14 / ZrO2

Vibrating grinders are designed to comminute samples to a finely dispersed state in intermittent operation. The VG 6 vibrating grinder is designed for simultaneous comminution of six small (up to 5 cm3) samples. Characteristics VG 6 Cup charging volume - 2-5 (cm3) Number of cups - 6 Maximum material feed size - 2 (mm) Vibration frequency – 1,500 (vibrations / minute) Vibration amplitude - 3,5 (mm) Comminution time - 1–30 (minutes) Maximum material hardness -8 Mohs units Electric motor power - 0,37 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length х Width х Height) - 509х395х310 (mm) Weight - 54 (kg) Grinding element material – tool steel / zirconium dioxide / wolfram carbide - AISI 01, DIN 150Cr14 / ZrO2 / WC

Vibrating grinders are designed to comminute samples to a finely dispersed state in intermittent operation. Vibrating grinder VGE is designed for grinding samples from 250 to 750 ml with high productivity. The main purpose of VGE is the grinding of samples to an analytical size of less than 74 micrometers in the mining and metallurgical laboratories. Characteristics VGE Cup charging volume - 250 – 750 (cm3) Number of cups - 1 Maximum material feed size - 20 (mm) Vibration frequency - 1,500 (vibrations / minute) Vibration amplitude - 16 (mm) Comminution time - 1–30 (minutes) Maximum material hardness 7 Mohs units Electric motor power - 2,2 (kW) 50 Hz supply voltage - 380 (V) Overall dimensions (Length х Width х Height) - 670х615х1225 (mm) Weight - 350 (kg) Grinding element material – tool steel / zirconium dioxide / wolfram carbide - AISI 01, DIN 150Cr14

Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications DP 5 Riffle width - 5 (mm) Total volume of sample receivers 3х0,77/ 3х0,5 (dm)3 Number of riffles -20 Material feed size maximum 1,5 (mm), Overall dimensions (mm) (Length х Width х Height) - 247х161х223 Weight 3,5 (kg)

Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications DP 10 Riffle width 10 (mm) Total volume of sample receivers 3х1,2/ 3х0,78 (dm)3 Number of riffles 16 Material feed size maximum 3 (mm) Overall dimensions (Length х Width х Height) 247х218х223 (mm) Weight 4,8 (kg)

Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications DP 15 Riffle width 15 (mm) Total volume of sample receivers 3х4,8/ 3х3,1(dm)3 Number of riffles 16 Material feed size maximum 5 (mm) Overall dimensions (Length х Width х Height) 434х299х343 (mm) Weight 13,3 (kg)

Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications DP 20 Riffle width 20 (mm) Total volume of sample receivers 3х9,6/ 3х6,3 (dm)3 Number of riffles 16 Material feed size maximum 6,5 (mm) Overall dimensions (Length х Width х Height) 522х403х403 (mm) Weight 18,7 (kg)

Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications DP 25 Riffle width 25 (mm) Total volume of sample receivers 3х17,5 / 3х12,5 (dm)3 Number of riffles 20 Material feed size maximum 8 (mm) Overall dimensions (Length х Width х Height) 600х546х403 (mm) Weight 27,5 (kg)

Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications DP 37,5 Riffle width 37,5 (mm) Total volume of sample receivers 3х17,5 / 3х12,5 (dm)3 Number of riffles 14 Material feed size maximum 12,5 (mm) Overall dimensions (Length х Width х Height) 600х546х403 (mm) Weight 26,5 (kg)

Riffle sample splitters are designed to divide samples of bulk materials into two parts of equal size and with equal content. Specifications DP 50 Riffle width 50 (mm) Total volume of sample receivers 3х17,5 / 3х12,5 (dm)3 Number of riffles 10 Material feed size maximum 16,5 (mm) Overall dimensions (Length х Width х Height) 600х546х403 (mm) Weight 26,5 (kg)

The Sieve Shakers are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics A 12 Sieve diameter -120 (mm) Maximum number of sieves - 10 Type of vibration drive: VP 30, VP 30T, VPS Amplitude of vibrations (depending on weight of sample and number of sieves) - 0,25-0,75 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220 (V) Maximum overall dimensions: Length - 390 (mm) Width - 350 (mm) Height - 684 (mm) Maximum weight - 23 (kg)

The Sieve Shaker А 20 are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics A 20 Sieve diameter -200 (mm) Maximum number of sieves - 8 Type of vibration drive: VP 30, VP 30T, VPS Amplitude of vibrations (depending on weight of sample and number of sieves) - 0,25-0,75 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220 (V) Maximum overall dimensions: Length - 390 (mm) Width - 350 (mm) Height - 760 (mm) Maximum weight - 26 (kg)

The Sieve Shaker А 30 are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics A 30 Sieve diameter -300 (mm) Maximum number of sieves - 6 Type of vibration drive: VP 30, VP 30T, VPS Amplitude of vibrations (depending on weight of sample and number of sieves) - 0,25-0,75 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220 (V) Maximum overall dimensions: Length - 390 (mm) Width - 350 (mm) Height - 650 (mm) Maximum weight - 28 (kg)

The Sieve Shaker А 40 are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics A 40 Sieve diameter -400 (mm) Maximum number of sieves - 10 Type of vibration drive: VP 50 Amplitude of vibrations (depending on weight of sample and number of sieves) - 2-4 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220/380 (V) Maximum overall dimensions: Length - 576 (mm) Width - 576 (mm) Height - 1236 (mm) Maximum weight - 136 (kg)

The Sieve Shaker А 50 are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics A 50 Sieve diameter - 500 (mm) Maximum number of sieves - 8 Type of vibration drive: VP 50 Amplitude of vibrations (depending on weight of sample and number of sieves) - 2-4 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220/380 (V) Maximum overall dimensions: Length - 560 (mm) Width - 550 (mm) Height - 1100 (mm) Maximum weight - 101(kg)

The Sieve Shaker A 20x4 (on base VP 50) are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics A 20x4 Sieve diameter - 200 (mm) Maximum number of sieves - 4x10 Type of vibration drive: VP 50 Amplitude of vibrations (depending on weight of sample and number of sieves) - 2-4 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220/380 (V) Maximum overall dimensions: Length - 560 (mm) Width - 550 (mm) Height - 1000 (mm) Maximum weight - 100(kg)

The Sieve Shaker A 30 (on base VP 50) are designed for intermittent dry sieving of bulk materials according to particle size. The Sieve Shaker consists of a vibration drive with a set of sieves installed, a tray, a cover and a device for fastening the sieves. Characteristics A 30 (on base VP 50) Sieve diameter - 300 (mm) Maximum number of sieves - 12 Type of vibration drive: VP 50 Amplitude of vibrations (depending on weight of sample and number of sieves) - 2-4 (mm) Vibration frequency - 1500 (vibrations/minute) 50 Hz supply voltage - 220/380 (V) Maximum overall dimensions: Length - 565 (mm) Width - 550 (mm) Height - 1155 (mm) Maximum weight - 82(kg)

The Cyclone dust collector is designed to create an air flow that captures the duct fraction of the material crushed and settles it in a cyclone and bag filter. The primary components of the product are a fan, cyclone with shutter, frame and bag filter. The support structure has wheels equipped with brakes for moving the dust collector. The dust collector has an adjustable exhaust hood for use as a local exhaust unit. The exhaust hood can be used as an air intake in both the loading zone and discharging zone. Advantages Cleaning the dust fraction larger than 15 µm from the air flow; Periodic discharging of material from the cyclone through a gate; Connection of the dust collector to two types of hose: Ø70 for DRC 200х125, НМ 2х2, JC 6М, JC 10М and JC 15; Ø200 for HM 5х2, HM 5х5 and СM 250; Connection of the dust collector to several units of equipment via T-joints; Use of the dust collector with hood as a local

Options for sieve surfaces: screen or perforated sheet. Screen material: brass, bronze, stainless steel or polyamide. Shape of stainless steel sheet apertures: round or square. Sieve S 12/38 diameter 120 mm, height 38 mm. Characteristics S 12/38 Inner frame diameter - 120 (mm) Mesh size - 0,02-4 (mm) Size of apertures in perforated plate - 0,8-50 (mm) Weight - 0,12 (kg) Maximum sample weight 0,1 (kg) Maximum load on sieve with perforated plate 0,3 (kg)

Options for sieve surfaces: screen or perforated sheet. Screen material: brass, bronze, stainless steel or polyamide. Shape of stainless steel sheet apertures: round or square. Sieve S 20/38 diameter 200 mm, height 38 mm. Characteristics S 20/38 Inner frame diameter – 200 (mm) Mesh size - 0,020-4 (mm) Size of apertures in perforated plate * (mm) Weight - 0,2 (kg) Maximum sample weight - 0,15 (kg) Maximum load on sieve with perforated plate * (kg) * The design of the sieves does not require the use of a perforated plate sieve element.

Options for sieve surfaces: screen or perforated sheet. Screen material: brass, bronze, stainless steel or polyamide. Shape of stainless steel sheet apertures: round or square. Sieve S 20/50 diameter 200 mm, height 50 mm. Characteristics S 20/50 Inner frame diameter - 200 (mm) Mesh size - 0,020-4 (mm) Size of apertures in perforated plate - 0,8-100 (mm) Weight - 0,5 (kg) Maximum sample weight - 0,2 (kg) Maximum load on sieve with perforated plate - 0,5 (kg)

Options for sieve surfaces: screen or perforated sheet. Screen material: brass, bronze, stainless steel or polyamide. Shape of stainless steel sheet apertures: round or square. Sieve S 30/50 diameter 300 mm, height 50 mm. Characteristics S 30/50 Inner frame diameter - 300 (mm) Mesh size - 0,04-4 (mm) Size of apertures in perforated plate - 0,8-150 (mm) Weight - 0,75 (kg) Maximum sample weight - 0,3 (kg) Maximum load on sieve with perforated plate - 1 (kg)

Options for sieve surfaces: screen or perforated sheet. Screen material: brass, bronze, stainless steel or polyamide. Shape of stainless steel sheet apertures: round or square. Sieve S 20/100 diameter 200 mm, height 100 mm. Characteristics S 20/100 Inner frame diameter - 200 (mm) Mesh size - 1-4 (mm) Size of apertures in perforated plate - 0,8-100 (mm) Weight - 0,6 (kg) Maximum sample weight - 0,5 (kg) Maximum load on sieve with perforated plate - 0,5 (kg)

Options for sieve surfaces: screen or perforated sheet. Screen material: brass, bronze, stainless steel or polyamide. Shape of stainless steel sheet apertures: round or square. Sieve S 30/100 diameter 300 mm, height 100 mm. Characteristics S 30/100 Inner frame diameter - 300 (mm) Mesh size - 1-4 (mm) Size of apertures in perforated plate - 0,8-150 (mm) Weight - 1 (kg) Maximum sample weight - 0,75 (kg) Maximum load on sieve with perforated plate - 1 (kg)

Options for sieve surfaces: screen or perforated sheet. Screen material: brass, bronze, stainless steel or polyamide. Shape of stainless steel sheet apertures: round or square. Sieve S 40/70 diameter 400 mm, height 70 mm. Characteristics S 40/70 Inner frame diameter - 400 (mm) Mesh size - 0,2 - 4 (mm) Size of apertures in perforated plate - 0,8-200 (mm) Weight -3 (kg) Maximum sample weight - 0,6 (kg) Maximum load on sieve with perforated plate - 2 (kg)

Options for sieve surfaces: screen or perforated sheet. Screen material: brass, bronze, stainless steel or polyamide. Shape of stainless steel sheet apertures: round or square. Sieve S 50/70 diameter 500 mm, height 70 mm. Characteristics S 50/70 Inner frame diameter - 500 (mm) Mesh size - 0,315-4 (mm) Size of apertures in perforated plate - 0,8-200 (mm) Weight - 3,5 (kg) Maximum sample weight - 1 (kg) Maximum load on sieve with perforated plate -3 (kg)

Options for sieve surfaces: screen or perforated sheet. Screen material: brass, bronze, stainless steel or polyamide. Shape of stainless steel sheet apertures: round or square. Sieve S 40/140 diameter 400 mm, height 140 mm. Characteristics S 40/140 Inner frame diameter - 400 (mm) Mesh size – 1-4 (mm) Size of apertures in perforated plate - 0,8-300 (mm) Weight - 3,5 (kg) Maximum sample weight - 1 (kg) Maximum load on sieve with perforated plate -2 (kg)

The «Drum Tumbler» M 50.0 shaker mixer is industrial-class equipment used in busy laboratories and small industrial facilities. Technical characteristics M 50.0 Cup/drum volume 50 (dm3) Cup rotational speed 49 (rpm) 50 Hz supply voltage 380 (V) Electric motor power 0,75 (kW) Overall dimensions (Length x Width x Height) 1155х770х1000 (mm) Drum material Stainless steel

What are you doing with your unused HPLC system or module? Last months Labrecycling sold a lot of HPLC systems, therefore we are searching for new "old and unused" HPLC systems. Don`t you sell used HPLC systems, but you want to buy? Labrecycling is your partner. We search among other things: •Agilent 1100, 1200, 1260 & 1290 •Shimadzu LC10, LC20, Nexera & Prominence •Thermo Ultimate 3000 & Accela •Waters Alliance 2695, e2695 & Acquity Labrecycling recycles chromatographic instruments and has room to take over your equipment. Throwing away is a sin. Make your warehouse clear and give your HPLC a 2nd life. Come in contact: Call/WhatsApp +316 14 12 25 25. Or send us an e-mail:

Users can collaborate in real-time on Microsoft Office documents within the CDD Vault platform Collaborative Drug Discovery (CDD), provider of the CDD Vault web-based research informatics platform, announced that it has officially joined the Microsoft Cloud Storage Program. As part of this group of software vendors, CDD now provides direct integration of Microsoft Office 365 and CDD Vault Electronic Lab Notebook (ELN). This notable product enhancement offers a multitude of benefits. Users now enjoy the convenience of viewing and editing Office documents, including benefiting from powerful Microsoft Word, Microsoft Excel, and Microsoft PowerPoint functionalities, without leaving the CDD Vault environment. The open-edit-save workflow is handled in CDD’s secure server environment, eliminating the need to download and manage local copies. The ability for multiple users to access and modify a given document facilitates real-time collaboration. “Many of our customers store Microsoft Office documents within their CDD Vaults. We are pleased to enable a seamless transition

Successfully Going Live with New LIMS in COVID-19 Lockdown On March 23rd 2020 amidst the Covid-19 pandemic and enforced operational changes, Norfolk and Norwich University Hospital (NNUH) went live with the Achiever Medical laboratory information management system (LIMS). The unconventional go live was conducted virtually. Online hand-holding sessions connected members of Interactive Software Limited’s (ISL) project team with members of the NNUH and Quadram Institute Bioscience. The Norwich Research Park Biorepository is a partnership between Norfolk and Norwich University Hospital, Quadram Institute Bioscience (QIB) and the University of East Anglia and provides samples of human tissue to health researchers. The Biotechnology and Biological Sciences Research Council provided £3.5 million of capital funding towards the project. The NRP BioRepository provides samples to researchers across the Norwich Research Park, its associated hospitals as well as externally. Its aim is to leverage samples within its tissue bank to improve

B-403 ideal for short term identification Easily colour code items with a temporary label that fully dissolves in 30 seconds in warm water. The B-403 water dissolvable label is ideal for short term identification. The B-403 water dissolvable paper label is self-adhesive and extremely easy to apply. Exposing the label to warm water will completely dissolve it within 30 seconds, without damage to the surface it was applied to, and without leaving any residue. B-403 reduces the labour required to remove labels, reduces maintenance to filters and drains and enables easy re-identification of reusable items in a range of industries. The water dissolvable label adheres well to most surfaces, including glass, stainless steel, aluminium, plastic and others. This makes the label a great solution to enable short term identification for containers, crates and glassware with a minimum of waste.

Pharma industry’s organised gathering will run new global biosafety measures to ensure the highest standards o Amsterdam, 03 June 2020: CPhI Worldwide – organised by Informa Markets – will this year be organised in accordance with Informa’s AllSecure health and safety standard in response to COVID-19. As a leading events’ organiser, Informa has developed a detailed set of measures to provide the highest levels of hygiene and safety at its events, which include enhanced cleaning, physical distancing systems and onsite monitoring and protection. Informa AllSecure provides everyone with reassurance they are participating in a safe and controlled environment. The Pharma industry is playing a key role in fighting the pandemic, delivering medicines and maintaining vital supply chains globally, so it’s important that we empower the industry with the tools to function as effectively as possible. “We have worked with our parent company, Informa, to make health and safety a priority at our flagship event later in the year through a range of measures to ensure everyone involved is able