News items February 2021

BOC Sciences announced that it will comprehensively promote the enhancement of its ADC conjugation technology platform and strengthen its cooperation with global biotechnology companies specializing in the development of antibody-conjugated drugs (ADCs) technology. Before announcing this news, BOC Sciences had comprehensively laid out its ADC payload and linker development and manufacturing plants last year. This company will combine years of efficient small molecule expertise and advanced ADC technology to develop integrated services & products for existing and potential customers. An effective antibody-drug conjugate (ADC) must conjugate an effective drug/linker combination to the antibody to determine the optimal amount of drug carried by a single antibody. In addition, the linker must remain stable in the system circulation to minimize adverse effects, but it must be cleaved quickly after the ADC finds its intended target antigen. BOC Sciences claims that its

As a professional service provider in the field of Proteolysis Targeting Chimeric (PROTAC) technology, BOC Sciences offers a number of research and development outsourcing services. Recently, BOC Sciences announced that its PROTACs technology platform can provide E3 ubiquitin ligase activity assay services to assist drug development. E3 ubiquitin ligase plays an important role in specifically recognizing target proteins and regulating the efficiency of ubiquitin reaction. The specificity of E3 protein substrates can be reprogrammed to treat diseases with effective and selective small molecular ligands targeting E3 ligases. The human genome encodes more than 600 kinds of E3 ubiquitin ligases, but only some of them can be recruited to degrade the target protein (POI), such as von Hippel-Lindau (VHL), cereblon (CRBN), inhibitors of apoptosis (IAPs), and mouse double minute 2 homolog (MDM2). E3 ubiquitin ligase activity affects the ubiquitin process, thus affecting the

In drug development and production, solid active pharmaceutical ingredients, which are usually made into powders or tablets, are a preferred choice compared with liquid active pharmaceutical ingredients. If solid active ingredients are to be finally marketed, the issue of solubility must be solved. 40-70% of drug development failures are due to poor solubility. This is because drugs of poor solubility cannot be well-absorbed by the body.   Ionic liquids (alfa-chemistry.com/products/ionic-liquids-148.htm), as an exciting class of compounds that can circumvent the above problems, are being ignored. Half of the drugs currently on the market are salts linked together by ionic bonds. Compared with the solid form, the salt that is liquid at room temperature or body temperature has better solubility, absorption and stability. Ionic liquids can also deliver two or more active ingredients at once. For example, by combining the active ions of the painkiller procaine with non-steroidal

Water analysis is often viewed as the groundwork of studies of water quality, pollution, hydrology and geothermal waters. In order to better serve clients worldwide, Alfa Chemistry Testing Lab, a cGMP-compliant laboratory of Alfa Chemistry, today announces to upgrade its water analysis and testing services. Taking advantage of strong expertise and decade-long experience, the lab is now capable of conducting analytical testing for environmental water, drinking water supplies, industrial process water as well as other types of water. The biggest priority of water chemistry analysis is to identify and quantify the chemical components and properties of water samples, either it is water used in industrial processes or on waste-water streams or on rivers and streams or on rainfall and on the sea. Analytical methods routinely are gas chromatography, ion chromatography, spectrophotometry and mass spectrometry. When appropriate methods are employed, the natural elements and

for Analytical and Chromatography Applications In a recent statement this month, Alfa Chemistry announced that company is starting to provide a wide range of ion sensor materials that could be used for analytical and chromatography applications. With all the previously released products added together, now Alfa Chemistry supplies a comprehensive collection of analytical chemistry reagents and it continues to expand the product line so as to meet the growing demand coming from new analytical testing scenarios. “Using ion selective electrode to convert the amount of ion to output signal, ion sensors have been widely used in the environmental sanitation field of factory drainage automatic measurement and river water monitoring, or for automatic monitoring of factory production solutions, laboratory daily analysis and other purposes,” commented a spokesperson from Alfa Chemistry. The types of ion sensor materials that are now readily available at Alfa Chemistry include: additives, buffers, ion standard solutions,

Accurate analysis of the ingredient composition will provide invaluable information. Alfa Chemitry’s T,C&A Lab, a newly launched testing lab branch, today announced to unveil its full range of ingredient analysis services for rubber products, plastic products, coatings, food, medicine, chemicals, metal products, oil products, electronics, machinery, lighting, furniture and other industries and related products. To conduct ingredients analysis for a product or sample, technical methods are needed to analyze the composition. Qualitative and quantitative analysis of each composition will be further performed. “Ingredient analysis is mainly used for the analysis of unknowns and unknown components. Via a quick determination of the compositions in the target sample, ingredient analysis can help identify materials, raw materials, additives, specific components and content, foreign objects and get as much information as possible,” says a spokesman from Alfa Chemistry. Roughly,

to Produce Organic and Printed Electronics The demand for battery materials with higher energy/power and improved safety is increasing, especially for the burgeoning markets in the energy & environmental industry. On February 9, 2020, Alfa Chemistry Materials, a provider of wide ranges of materials and chemicals, announced to supply battery materials, which can be used to produce organic and printed electronics or for research use. Currently, breakthroughs in materials design and engineering are urgently needed to meet the demands.   Battery materials refer to those materials that can make up the battery. The properties of battery materials decide the performances of batteries and the selection of battery materials significantly depends on open circuit voltage (OCV) of the cell. In general, battery materials can be widely used in the manufacturing of computer, communication and consumer electronic products, battery electric vehicles, and energy storage devices.   “Advances in battery technology have made it possible

for the Science Community The possibility of direct introduction of a new functionality via direct C-H bond transformation is a highly attractive strategy in covalent synthesis. To further facilitate scientists’ research work on carbon-hydrogen bond activation, Alfa Chemistry Catalysts recently announces to provide varieties of C-H activation catalysts, which are cost-effective and of high quality. Composed only of two elements, carbon and hydrogen, hydrocarbon is an important fuel and chemical raw material. C-H activation is a chemical reaction in which carbon-hydrogen bonds are cleaved and replaced by carbon-X bonds. Catalysts commonly used in such modification processes are transition metals such as Pd, Ru and Rh. “Because of the omnipresence of C-H bonds in organic compounds, they have become highly attractive targets for the installation of functional groups in a hope to construct valuable molecular scaffolds. Therefore, C-H activation has become an important, modern tool for organic

Long non-coding RNA is a relatively good class of non-coding RNA (ncRNA) molecules that are involved in the regulation of various cellular processes, including transcription, intracellular transport and chromosome remodeling. Their disorders are related to the occurrence and development of various cancer types, and this fact makes them suitable as biomarkers for cancer diagnosis and prognosis. In recent years, detecting cancer-related lncRNAs in the body fluids of cancer patients has proven to be a particularly valuable method for effective cancer diagnosis. Compared with classic tumor biopsy, the diagnosis and prognosis of cancer using circulating lncRNA is preferred, especially because of their non-invasiveness and great potential for routine application in clinical practice. One of the main advantages of making lncRNAs suitable as cancer diagnostic and prognostic biomarkers is their high stability when circulating in body fluids, especially when contained in exosomes

Recently, in a research report published in the international journal of Scientific Reports, scientists from the Russian Far Eastern Federal University and other institutions used the developing eyes of fruit flies as a detection platform to conduct research and found that the overproduction of a protein called RPS-12 seems to induce triple-negative breast cancer and certain malignant tumors. When the embryo develops, this protein can indirectly turn on an important intracellular signaling pathway. Based on the results of this article, scientists have taken another step forward in the development of tumor-targeted therapies. The idea of this therapy is to identify targeted proteins that play a guiding role in tumor initiation or progression. In order to inhibit the growth of tumors while minimizing damage to healthy cells; using cDNA libraries derived from Drosophila and triple-negative breast cancer patients, researchers have launched a large-scale screening of potential

Researchers at the University of Texas MD Anderson Cancer Center found that a protein called NF-κB-inducible kinase (NIK) is essential for changes in metabolic activity caused by T cell activation, making it a regulator of T cell anti-tumor activity Key factors. Preclinical studies published in the journal Nature Immunology indicate that increasing the activity of NIK in T cells may be a promising strategy for enhancing the effectiveness of immunotherapy (including T cell transplantation and immune checkpoint blockade). In preclinical melanoma models, the researchers evaluated melanoma-specific T cells that have been engineered to express higher levels of NIK. Compared with the control group, these T cells showed stronger tumor killing ability and improved survival rate, indicating that increasing NIK activity can improve the effectiveness of T cell therapy. "NIK is a new type of T cell metabolism regulator, and its role is very unique. From a biological point

Creative BioMart Microbe, with a mature microbial technology service platform, provides microbial technology services to customers worldwide, including the pharmaceutical production industry and drug development researchers. Now a wide selection of microbial services for customers in the drug development field are available. Microorganisms have always played an important role in the quality assurance and quality control of drugs. For example, in the production of injectable drugs, microbiological testing of water for injection, the production environment and the product is required to monitor the quality of the drug and the production process. With the development of science, there have been some changes in pharmaceutical microbiology. Microorganisms are not only closely related to drug production, but also play a role in drug development. Based on the information on the official website of Creative BioMart Microbe, the services for drug development mainly include: Microbial

In this article, a number of important research results have been sorted out to jointly focus on the new achievements of scientists in the study of biomarkers. CancerRes: Scientists identify novel potential biomarkers or are expected to help develop individualized anti-cancer therapies Recently, in a study published in the Cancer Research, scientists from institutions such as Duke-NUS Medical School have discovered a potential way to predict which patients will respond to cancer therapies that block Wnt signaling, such as ETC-159, a novel drug developed in Singapore, and the results may help scientists develop novel individualized cancer therapies. Wnt protein is an important signaling molecule that helps surrounding cells communicate with each other, however, it induces cancer when the protein is produced in excess; Wnt protein is involved in the pathogenesis of a variety of common cancers, including colorectal cancer, breast cancer, leukemia and pancreatic cancer,

Profacgen, a US-based company specialized in protein related services, updated its one-stop services for isothermal titration colorimetry measurement to help scientists with their protein interaction analysis research. Isothermal titration calorimetry (ITC) is a technique used to quantitatively study the interactions of various biomolecules. It directly measures the heat released or absorbed during the binding of biomolecules. ITC is the only technique able to determine all binding parameters simultaneously in one assay. ITC can determine the affinity of the binding partner in the natural state without modification of the binding partner by fluorescence labeling or immobilization techniques. ITC has several advantages over other techniques for studying biomolecular interactions: it does not require any chemical modification or immobilization of any binding partner; the molecular weight of the reactant is not restricted, and it is not affected by spectroscopic properties

Creative Biostructure, a biotech company specialized in providing cost-effective contract services related to structural biology and membrane protein technologies to both academia and biotech industries, now applies its expertise in structural biology and membrane proteins to the drug discovery process for structure accelerated drug discovery. Now, Creative Biostructure performs comprehensive lead discovery and optimization solutions including library construction, library screening (in silico, in vitro and in vivo), hit-to-lead optimization and preclinical evaluation, etc. to customers all over the world. Lead discovery and optimization plays a crucial role to determine the quality of clinical candidates. After this process, a set of compounds can be screened that interact with the target and the confirmed hits have specific activity against the target. Modern drug discovery involves identifying screening hits, medicinal chemistry, and optimizing these hits to increase

Matexcel, a leading service provider in the material science, with years of commitment to supplying better polymers, nanoparticles and other materials for worldwide customers, now provides a wide selection of metal powders for research needs. When used in the manufacture of parts or as a coating for different parts, metal powders are very versatile. Aluminum-based and titanium-based alloys have been used in aerospace and automotive parts. The good combination of high strength and fracture resistance ensures that the cobalt alloy has reliable long-term performance in bioimplant applications. Stainless steel can be used for different hardware (prototypes, special tools, etc.) Matexcel is engaged in powder metallurgy, metal processing and additive manufacturing research and development. The company provides hybrid water gas atomization and plasma atomization technology to meet the needs of different customers. Their most popular products are titanium alloys, nickel-based

Lifeasible, with a team of experienced scientists in feed science and animal nutrition, now provides a series of AMP’s services against feed additives to satisfy agricultural developer’s requirements for green health and safety animal additives. Antibiotics are widely used for disease prevention and growth promotion in conventional livestock and poultry production. While antibiotics have successfully treated infections, the emergence and rapid spread of antibiotic-resistant bacteria pose a major risk to animal and human health. Now, antibiotic resistance has become a growing problem. It is estimated that by 2050, due to antibiotic-resistant infections, the global human death toll will reach 10 million, which exceeds the current death toll related to different forms of cancer. For this reason, it is urgently needed to develop new antibacterial drugs, such as alternative drugs based on antimicrobial peptides (AMPs). AMPs are produced by a variety of organisms, as a component

Cell immortalization is a necessary step for cancer development. Scientists believe that the main reason is to turn on an enzyme-telomerase-to extend chromosomal telomeres and prevent normal cell death. A new study shows that turning on telomerase is not a one-step process. In melanoma and possibly other cancers, mutations increase telomerase slightly, allowing cells to survive long enough to make other changes that upregulate telomerase. The key to immortality is an enzyme called telomerase, which keeps the chromosomes in cells that divide frequently. The enzyme lengthens the caps or telomeres at the ends of chromosomes, which are worn away during each cell division. When the telomeres are too short, the ends stick to each other, causing severe damage during cell division and in most cases killing the cell. Since telomeres become shorter as cells age, scientists believe that cancer cells that never age will be immortalized by turning on the production of telomerase

Recently, researchers from the UPMC Hillman Cancer Center and the National Cancer Institute (NCI) have shown that changing the gut microbiome can improve immunotherapy for patients with advanced melanoma. The results of this phase 2 clinical trial were published online in the journal of Science. In this study, a team of researchers from UPMC Hillman performed fecal microbiota transplantation (FMT) and anti-PD-1 immunotherapy on melanoma patients whose all available therapies (including anti-PD-1) failed, and then followed up the clinical and immunological results. NCI collaborators analyzed the microbiome samples of these patients to understand why FMT seems to enhance their response to immunotherapy. The lead author of the study, a medical oncologist, member of the UPMC Hillman Cancer Immunology and Immunotherapy Program (CIIP), and assistant professor of medicine at the University of Pittsburgh, Dr. Diwakar Davar, said: "FMT is just a means to an end." . "We know

Especially in neuroscience, the physiology of ion channels has always been a major topic of concern. The development of patch clamp technology in the late 1970s brought new prospects to electrophysiologists. It can record not only the high-resolution current of the entire cell, but also the high-resolution current of the excised cell mass, and can even investigate single-channel opening events. However, electrophysiology is still one of the most challenging methods in daily laboratory work due to its complex technical, physical and biological background, the need for highly sensitive equipment, and the large amount of skills required by experimenters. Electrophysiology is a technology pioneered in a specialized biophysics laboratory, which has now been extended to basic biology and medical research, and has become one of the most important tools for studying the behavior of single cells or entire cell networks in the nervous system. Patch-clamp technology allows the

Creative Proteomics Supports Biopharma Research with Protein Homogeneity Analysis Service Pronalyse, a new division of Creative Proteomics, is dedicated to providing professional analysis services in biopharmaceutical development. Creative Proteomics is an integrated CRO company with more than 10 years of experience in providing impurity analysis and analytical characterization service for bioprocess development. Recently, the product manager of Pronalyse division announced protein homogeneity analysis service to speed up the drug development process. In the past 20 years, the biopharmaceutical industry has made great strides. These biological drugs specifically include amino acids and their derivatives, peptides, monoclonal antibodies, recombinant proteins, vaccines, oligonucleotides, etc. Before clinical research, the biological activity or potency of biomolecules must be defined to ensure their drug efficacy. However, the complexity of biopharmaceuticals often poses challenges for evaluating structure, heterogeneity, aggregation, physical and chemical

CD Genomics Upgrades Microecology and Pharma Solutions for Speeding up Drug Discovery Process CD Genomics is a genomics service company with a good reputation for providing reliable microbial sampling products, microbial testing services, microbial genomics services, and integrated bioinformatics services. With years of experience in the pharmaceutical and life science sector, CD Genomics recently upgraded its microecology and pharma solutions. Empowered by leading technology and years of experience in biomedical science, CD Genomics Microbioseq division upgrades an optimized microecology and pharma solutions to support a drug`s journey from discovery to market. Microecology and pharmaceutical solutions can accelerate the research in drug target discovery, microbial therapy and microbial biomarker discovery. On the one hand, antibiotic resistance has become a major threat to modern medicine. Microbial genomics is a promising method to develop new antibiotics with new drug targets. Meanwhile, certain types of microorganisms can synthesize biologically active

Whole Genome Sequencing for GutFlora Now Available by the GutFlora Omics Platform GutFlora Omics Platform belongs to Creative Proteomics. With more than 10 years of experience in providing advanced multi-omics services, GutFlora Omics Platform offers services and support to customers through comprehensive intestinal flora research solutions. The product manager has recently announced the fully-developed whole-genome sequencing, which can work as a powerful tool in multiple areas including diagnosis, tracking disease outbreaks, characterizing causative mutations and identifying drug-resistance genes. More than 99% of the bacteria in the intestines are anaerobic bacteria, many of which have not been thoroughly studied because they cannot be cultured outside the host. Because traditional isolation and culture methods limit the research of intestinal flora, microbiome analysis can restore the comprehensive genetic information of intestinal flora, thus providing a convenient, efficient and comprehensive solution. These methods greatly benefit from 16S/18S/ITS

for Pharmaceutical Preparation Excipients play a remarkable role in the process of drug formulation. Binder excipients are used to improve the disintegration, bulkiness, bioavailability and dissolution rate of the drug. To make binder excipients more accessible for researchers, Formulationbio recently announced a comprehensive range of binder excipients that can be used in pharmaceutical research. By definition, the function of binder excipients is to act as an adhesive to “bind together” powders, granules and other dry ingredients, empowering the product enough mechanical strength. “Just like other excipients such as disintegrant or pH modifier, binders serve a specific purpose, that is, to provide sufficient cohesion for the powders which is needed in normal processing and at the same time, ensuring that the tablet will be disintegrated and the drug will be dissolved upon ingestion, thus releasing the active ingredients for absorption, ” says a spokesperson from Formulationbio. “Our company has

InertCap 624 for Ethanol is a dedicated column for the following pharmacopoeias test. InertCap 624 for Ethanol is a dedicated column for the following pharmacopoeias test. USP: Alcohol EP: Ethanol (96 percent) JP: Ethanol, Anhydrous Ethanol and Ethanol for Disinfection InertCap 624 for Ethanol stably yields the resolution of 1.5 between acetaldehyde and methanol in ethanol specified in the pharmacopoeias.

Your PoC Studies Partner CD BioScicences, a US based supplier of professional clinical trial services, is proud to reveal its capabilities in conducting Proof of Concept (PoC) studies. It’s a good news for drug development scientists in life science companies and organizations since they have another option when choosing a qualified CRO partner. Proof of Concept research is a critically important phase before entering early phase clinical trials and the later phase clinical trials. To simply put, PoC studies are designed to help scientists to gain insights of the practicality of the drug development concept or theory and make strategic decisions about whether and how to move on to the next drug development phase. In this case, the design and implementation of PoC studies become vital to scientists. CD BioSciences has rich experience in working with domestic and international pharmaceutical as well as biopharmaceutical clients in the early phase of drug development covering clinical pharmacology,

Excipients are very important for pharmaceutical preparations. It can be said that without excipients, there will be no pharmaceutical preparations, let alone different pharmaceutical dosage forms such as powders, granules, tablets, oral liquids or injections. When the drug and the appropriate excipients are combined into a specific dosage form, the drug would become safer, more stable and more convenient to use. Divided doses are easier to be accepted by the body. However, in addition to the above-mentioned effects, excipients of the drug are also one of the important factors that determine the effect of the preparation and how safe it is. What impacts will different excipients exert on the quality of pharmaceutical preparations? First, let us look at the excipients used in the production of dextran and β-cyclodextrin oligomers. This type of pharmaceutical preparations have a common feature, that is, after oral absorption, the drug will enter the body`s circulation.

Synthesis and reverse synthesis are important in organic chemistry. The purpose of reverse synthesis is to find reactants and synthetic routes that can synthesize the target compound. By using deep learning technology to learn chemical reaction-based data, artificial intelligence (AI) can help chemists design synthetic routes and select intermediate compounds, thereby greatly reducing the time required for drug design. Chemical Drug Development (aimed.protheragen.com/chemical-drug-development.html) Why is chemical synthesis so important in the entire biomedicine and pharmaceutical fields? As is known, the biomedicine and pharmaceutical R&D process can be roughly divided into two stages and the first is the preclinical stage, which involves the selection of protein targets and the selection and design of lead compounds (including the optimization and screening of lead compounds). After designing a good molecule, researchers can conduct in vitro and in vivo experiments.

for the Pharmaceutical Industry In recent decades, the requirements for drug formulations have increased significantly. To help scientists and researchers better solve the challenges arising from the formulation process, the AI-assisted R&D research company MedAI announces to release its drug formulation development service earlier this month. With this AI-driven formulation platform, formulation scientists now can develop clinically differentiable products more rapidly, comprehensively and intelligently.   A formulation refers to the composition of a drug product that contains both active pharmaceutical ingredients (API) and other inactive ingredients. Each inactive ingredient is added to the formulation for specific purposes so as to ensure the performance and conformance of drugs. Formulation development is of vital importance because it can determine patentability, lifecycle and, ultimately, the success of a pharmaceutical product.   “Our AI-driven formulation platform has integrated knowledge

Ever since the discovery of the two crystal forms of benzamide in the 18th century, scientists have been searching for the "superior drug crystal form" of innovative drugs. Obviously, crystal form research has become an important part of the drug development process. From a technical perspective, the research of drug crystal forms (aimed.protheragen.com/prediction-of-drug-crystal-form.html) can play a role in ensuring the quality of drugs. The solid state of the dominant drug can have one or more crystal forms, so one crystal form or a mixed state can be selected as the medicinal crystal form. The pursuit of "advantageous drug crystal form" has become the focus of current drug crystal form research. Then how can the crystal form of the drug be identified and analyzed?   There are currently a variety of methods to quantitatively and qualitatively analyze and identify drug crystal forms, and qualitative identification accounts for a relatively large proportion in pharmaceutical

Individual, extremely reliable and offering outstanding precision for chemical analyses and process technology Problem: The basic purpose of a peristaltic pump is to move fluids from A to B. This is not enough for manufacturers of analysis equipment and manufacturer of sensitive devices. Alongside the technical characteristics such as pulsation, accuracy and stability, they want their pumps to have their own attractive, individual appearance. Solution: SPETEC has been designing and building peristaltic pumps for an enormous range of applications. It also manufactures the required tubing, which must be as inert as possible in contact with solvents or acids and should have a long service life. Applications in these fields demand precision metering, an extremely stable technical process flow and, depending on the intended use, the lowest possible level of pulsation. These are the criteria underpinning the design of the two laboratory pump variants Perimax12 and Perimax16, which differ only in the number of rollers (12/16) in the pump head and the continuously adjustable flow rates

High quality meter and probes for glass-free pH measurement Wellinq Sensor Solutions offers a comprehensive line of high quality meters and probes for glass-free pH measurement. The meter line is created around our proprietary ISFET pH sensor that offers accurate and reliable pH measurements for demanding applications. The SI600 meter contains extensive features required for high-end pH measurements and is designed to work seamlessly with our SI series probes. * Accurate and reliable The SI600 meter’s advanced electronics can achieve a resolution of 0.005 pH for very sensitive pH measurements. The meter’s ability to offer reliable pH measurements in demanding conditions is the result of the robust ISFET sensor integrated into our probes. Unlike glass pH electrodes, ISFET pH sensors are highly resilient and do not require wet storage. * User friendly A large backlit 3.2” LCD colour display allows convenient determination of measurement values and provides clear information for operation. The pH value is displayed in a large

Providing key considerations and best practices when undertaking GPT for microbiological media QC Cherwell Laboratories, specialist supplier of products for environmental monitoring and process validation, has drawn on its extensive pharmaceutical and related industry knowledge to publish an eBook titled, “Growth Promotion Testing: A Guide to Good Practices” which is available to download from Cherwell’s website. The guide is intended for anyone involved in growth promotion testing of microbiological media, providing an overview of key considerations and best practice for this key quality control (QC) test. It particularly focuses on media used for pharmaceutical and sterile medical device industry applications; including environmental monitoring; process and operator validation; and product sterility testing. Given the critical nature of microbiological quality tests employed to ensure the safety of pharmaceutical products for human use, it is essential to undertake QC tests confirming the media used is fit for purpose. Before a new batch of culture media can

Vaisala launches the next-generation humidity and temperature transmitter series for hazardous environments Vaisala, a global leader in weather, environmental and industrial measurements, launches a new next-generation humidity and temperature transmitter series to take advantage of advancements in technology and to meet and exceed current hazardous area regulations. The new Vaisala HUMICAP© Intrinsically Safe HMT370EX Humidity and Temperature Transmitter Series builds on over 20 years of experience with the trusted Vaisala HMT360 series with an even more robust and easy-to-use design. “We are pleased to introduce the HMT370EX series which offers improved user experience, better corrosion resistance, and the latest Vaisala humidity measurement performance. It’s a true successor to our trusted HMT360 product series, and it can be effortlessly installed into existing systems,” says Product Manager Juhani Lehto of Vaisala’s Industrial Measurements. Ideal solution for measuring humidity in hazardous environments HMT370EX series is designed specifically for hazardous and explosive

Professional Computational Biology Services for Drug Development Scientists ComputaBio, a supplier of professional computational biology solutions located in the US, introduces its molecular dynamics analysis services to drug development scientists worldwide. The company keeps expanding its capabilities and continuously enlarges its service portfolio in computational biology. Current years have witnessed a creeping-up tide of computer-aided drug development. Molecular dynamics (MD), as a powerful supplement to theoretical calculations and experimental methods, has been increasingly popular in the drug development industry. However, molecular dynamics simulations return fast calculation as well as highly complex data. To extract the useful information from the data, further accurate analysis of the data is needed. To satisfy scientists’ needs in analyzing such complex data, ComputaBio launches its molecular dynamics analysis services. The company carries out a variety of molecular dynamics analysis services for global customers, including

A dormant danger? Additives in the textile industry improve product properties or simplify processing. During the manufacture of textile fibres and the production of the garments made from the fibres, they pass through a great number of processing steps in which a large number of chemicals are also used. Ideally, only the finishing chemicals, as well as the dyes, remain in the final product, but other chemicals that can have harmful effects on health have also been detected in textile pieces. Fritsch offers the possibility to grind textiles and protective masks with the Universal Cutting Mill Pulverisette 19 and thus prepare them for further analysis. Processing of textiles The task was to comminute textiles and FFP2 protective masks with the Pulverisette 19. In the first step, the textiles were manually pre-shredded to a size of approx. 7 x 8 cm. First test The Pulverisette 19 was equipped with the standard rotor with V-cutting edges in hardened stainless steel, and a sieve cassette

The science-driven board will support small and medium biotechs with expert scientific knowledge The newly formed Scientific Advisory Board (SAB) of Europital – a globally-focused, full-service CRO serving small and mid-tier innovators – forewarns that a clinical knowledge deficit amongst smaller biotechs will potentially slow trials in 2021. The Europital SAB, comprises a group of clinical KOLs and specialized industry experts and has been created to address many of the more complex targets and biologies that now proliferate in the drug discovery pipeline. “The drug discovery pipeline is increasingly made up of smaller and more nimble innovators with limited clinical experience in-house. Yet, with many of the low hanging fruit already having been developed, molecules and biologies are becoming ever more complex. The challenge for small and medium pharma and biotechs is how to access appropriate high-quality clinical knowledge – and this clinical deficit over the next few years is set to be a critical factor in any candidates advancement,” commented Dr. Mohamed

Your Capable Hand in Clinical Development CD BioScicences, a supplier of whole lifecycle clinical trial services, introduces its first-in-human (FIH) study service to worldwide scientists in biological and pharmaceutical institutes and companies who are in need of a capable hand in expediting their clinical programs. First-in-human (FIH) studies are a critical step in drug development process and play a key role in supporting the rapid progression of clinical trials. The design of FIH studies is typically to characterize a candidate drug’s pharmacokinetics, potential effective concentration or dose, and molecule safety and tolerability. Although a common consensus on the design and conduct of FIH studies is not available, approaches that could enhance the candidate drug’s predictive nature and FIH studies’ adaptive nature could greatly accelerate the drug development. With a team of experienced professionals in clinical pharmacology, safety evaluation, formulation, clinical development and operation, toxicological

Your New Option of MD Simulation services ComputaBio, a supplier of professional computational biology services based in the US, has launched molecular dynamics simulation services for industrial and academic clients to better their capability for drug design and expedite drug development programs. With the continuous improvements in both computer power and algorithm design, a tide of computer-aided drug design is creeping up. Molecular dynamics (MD) simulations, as a powerful supplement to theoretical calculations and experimental methods as well as a useful technique to effectively understand macromolecular structure-to-function relationships, play an increasingly important role in data-driven drug discovery. Molecular dynamics simulations are widely used for the structure-function studies of common-seen molecules such as proteins, peptides, enzymes, lipids, and etc. It has evolved into a mature technique frequently seen in the fields of chemistry, material science, biomedicine, and physics. The applications

February 02, 2021: Bristol Myers Squibb and WuXi STA – a subsidiary of WuXi AppTec – today announced that WuXi STA has agreed to purchase Bristol Myers Squibb’s manufacturing facility in Couvet, Switzerland. The Couvet site will be the first facility in Europe for WuXi STA, a leading Contract Development and Manufacturing Organization. The acquisition will enhance WuXi STA’s existing capabilities while growing capacity to support its partners’ life-saving work. The companies anticipate completing the transaction by Q2 2021, subject to regulatory approvals and the satisfaction of other closing conditions. Upon closing, WuXi STA will acquire the Couvet site’s operations and assets, which include the plant and equipment, as well as a workforce with technical capabilities and expertise. “The Couvet site is a world-class facility designed for quality, safety, and efficiency, and we believe WuXi STA will be able to leverage the capacity and capabilities for its own operations

Pronalyse is a new division of Creative Proteomics, which is an integrated CRO company with rich experience in providing drug development service for over 10 years. Pronalyse is dedicated to providing professional analysis services in biopharmaceutical development. Recently, the product manager has announced the vaccines analysis service to ensure the safety, efficacy, purity and potency of vaccine products. Vaccines have historically been the most effective means to provide active acquired immunity and fight against infectious diseases. A vaccine typically contains an agent that stimulates the body`s immune system to recognize the agent as a threat, destroy it, and keep the memory of it. These agents are commonly based onpurified protein antigens from natural origin or produced by recombinant DNA, polysaccharides, semi-synthetic poly- or oligosaccharide-protein conjugates and novel nucleic acid constructs. Vaccines can be divided into different types that represent

As an excellent supplier and manufacturer located in New York, Creative Enzymes has recently optimized lysozyme for researchers in the life science field. After years of experience in serving companies and research institutes, Creative Enzymes has been proved the high reliability of its services and is able to offer remarkable enzymes related services or products for researchers. Enzymes are special proteins with catalytic activity and high selectivity produced by living cells. Enzymes existing in nature are not completely suitable for application in life and production. Enzyme engineering technology is used to transform enzymes to make them more in line with needs. There are thousands of enzymes known, but they are still far from meeting people`s increasing needs for enzymes. With the development of science and technology, people are discovering more and better new enzymes. Among them, the research and development of lysozyme has become an important direction. Lysozyme