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What are PEG Linkers? PEG Linker
What are PEG Linkers?
PEG Linker Hydrophilic poly(ethylene glycol) or PEG-linkers are particularly attractive as a linker for conjugation. Water solubility, lack of toxicity; low immunogenicity and well defined chain lengths and molecular weights are specific characteristics of PEG moieties relevant to pharmaceutical applications. Hydrophilic linkers The link between the antibody and the cytotoxic agent plays a critical role in development of antibody-drug conjugates. The nature of the linker can significantly affect the potency, selectivity, and the pharmacokinetics of an antibody-drug conjugate. A common feature of numerous linkers used to prepare antibody-drug conjugates is their hydrophobicity – or their inability to dissolve in water.  In most cases, the average drug-to-antibody ratio (DAR) or the number of drug molecules per antibody does not exceed 3-4 drug molecules per antibody molecule.  Many of the problems seen with hydrophobic linkers can be overcome by sulfonate- or PEG-containing hydrophilic
24-06-2020  |  114x  |  Product news  | 
Development Base and Future Trends of RNA Drug Research
RNA used to be considered just a molecule that passed information between genes and proteins. In fact, at the beginning of life, RNA is the only living molecule, which can store information and also has the function of an enzyme. It took millions of years of evolution and evolution to produce DNA and protein molecules. In addition to acting as a messenger (mRNA) for protein synthesis, RNA also has a very important regulatory function, such as non-transcribed RNA includes miRNA, siRNA, lncRNA, piwiRNA, etc. Among them, there are more than 400 miRNA molecules alone, regulating at least one-third of human genes. Since the discovery of the DNA double helix structure, scientists began research on the realization of "programmed" pharmaceuticals based on the genetic information contained in nucleic acids and the base pairing law. The earliest beginning of RNA drug research includes antisense nucleic acid (ASO), small interfering nucleic acid (siRNA), aptamer, aptamer, snRNA,
22-06-2020  |  080x  |  Industry news
Enzymes for Coronavirus Nucleic Acid Test Can Help Detection of COVID-19
Enzymes for Coronavirus Nucleic Acid Test Can Help Detection of COVID-19
As we know, COVID-19 is a serious global infectious disease outbreak with nearly 8,470,000 cases and around 453,000 deaths worldwide. As a professional biotech company, Creative Enzymes has the core technology in enzyme modification and expression. During this pandemic, it releases enzyme products for coronavirus nucleic acid detection to help fight against the disease. The COVID-19 coronavirus disease is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. Common symptoms include fever, cough, and shortness of breath. Other symptoms may include muscle pain, sputum production, diarrhea, sore throat, loss of smell, and abdominal pain. The World Health Organization officially announced the outbreak of COVID-19 as a global pandemic in March this year. “As long as COVID-19 threatens any country, the entire world is at risk and therefore every effort must be made to avoid mistakes of the past by ensuring protection is extended to everyone on
19-06-2020  |  111x  |  Industry news  | 
CD Genomics Releases Kits and Reagents for Coronavirus Research CD Genomics Releases Kits and Reagents for Coronavirus Research to Aid in COVID-19 Response
CD Genomics Releases Kits and Reagents for Coronavirus Research
CD Genomics Releases Kits and Reagents for Coronavirus Research to Aid in COVID-19 Response COVID-19 is a serious global infectious disease outbreak with nearly 6,800,000 cases and around 397,000 deaths worldwide. As a professional biotech company, CD Genomics` Kits and reagents are based on some of the most powerful platforms. During this pandemic, it releases Kits and reagents products for coronavirus detection and research to help fight against the disease. The COVID-19 coronavirus disease is an infectious disease caused by severe acute respiratory syndrome coronavirus 2. Common symptoms include fever, cough, and shortness of breath. Other symptoms may include muscle pain, sputum production, diarrhea, sore throat, loss of smell, and abdominal pain. The World Health Organization officially announced the outbreak of COVID-19 as a global pandemic in March this year. “As long as COVID-19 threatens any country, the entire world is at risk and therefore every effort must be made to avoid mistakes of the past by ensuring protection is extended to everyone on
16-06-2020  |  129x  |  Product news  | 
FRITSCH sieve Shakers: Everything you need for sieving Convenient – Precise - Reliable
FRITSCH sieve Shakers: Everything you need for sieving
Convenient – Precise - Reliable The Fritsch sieve range is the focused answer to all typical sieving tasks in the laboratory: three well-conceived instruments for every application, with Fritsch concepts that make the work simpler and faster – easy to operate, reliable and long-lasting. FRITSCH sieve Shakers are ideal for - Dry, wet and micro-precision sieving - Measuring the quantitative particle size distribution of solids and suspensions - Separating and fractioning - Simple, ergonomic operation - Fast, reproducible results - Sample quantities between 0.05 g and 15 kg - Sieve diameter from 100 mm to 450 mm, mesh widths from 5 μm – 125 mm - Can be used as testing equipment in accordance with Din en iso 9001 - Automatic sieve evaluation with the Fritsch software Autosieve Vibratory Sieve Shaker Analysette 3 PRO – precise sieving with amplitude control The high performance Vibratory Sieve Shaker Analysette 3 PRO offers everything you need for fast determination of quantitative particle size
16-06-2020  |  132x  |  Product description  | 
Alfa Chemistry Testing Lab Offers an Exclusive Regulatory Resouece Section
Alfa Chemistry Testing Lab Offers an Exclusive Regulatory Resouece Section
Starting from last year, the professional analytical testing organization Alfa Chemistry Testing Lab has been adding resources to its website regarding rules and regulations on the broad spectrum of testing and analysis for companies and agencies in the industry. As an expert in testing and analysis, Alfa Chemistry Testing Lab has an experienced technical team that uses advanced analytical equipment and technology to meet the needs of different customers in a wide range of areas, including environment, food, material, agriculture and crop, personal care & beauty, healthcare, fine chemical products, stationery & office supplies, building products, household & apparel, nano products and more. While conducting analytical testing for any sample material, the most important goal is make sure that the constituents are in compliance with relevant industry standards, thus safe for consumers once entering the market. FDA, industry associations and other regulatory bodies have
15-06-2020  |  164x  |  Industry news  | 
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