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Microbial R&D-scale Fermentation Services and Development Challenges
Fermentation is a process in which engineered microorganisms produce a large number of value-added intermediates or chemicals in a designed bioreactor. These products can be food supplements, medicines, industrial platform compounds, etc. As part of the upstream process, fermentation occurs before recovery, purification, preparation, filling and packaging in the biomanufacturing workflow. Creative Biogene has many years of experience in fermentation process development, and the services it provides are designed to provide customers with laboratory-level and pilot-scale fermentation services, as well as upstream and downstream processing development for R&D projects. Humans have been conducting fermentation experiments for thousands of years. However, bringing fermentation to an industrial scale is not simple. From technical barriers to regulations, industrial companies face many challenges. Fermentation is a biological process, and several parameters in the fermentor
23-01-2021  |  007x  |  Industry news
Microbial R&D-scale Fermentation Services and Development Challenges
Fermentation is a process in which engineered microorganisms produce a large number of value-added intermediates or chemicals in a designed bioreactor. These products can be food supplements, medicines, industrial platform compounds, etc. As part of the upstream process, fermentation occurs before recovery, purification, preparation, filling and packaging in the biomanufacturing workflow. Creative Biogene has many years of experience in fermentation process development, and the services it provides are designed to provide customers with laboratory-level and pilot-scale fermentation services, as well as upstream and downstream processing development for R&D projects. Humans have been conducting fermentation experiments for thousands of years. However, bringing fermentation to an industrial scale is not simple. From technical barriers to regulations, industrial companies face many challenges. Fermentation is a biological process, and several parameters in the fermentor
23-01-2021  |  005x  |  Industry news
Application of CRISPR/Cas9 Technology in The Generation of Gene Knock
Knock-in mice are an important research model in which foreign genes or DNA fragments are introduced into the mouse genome and transmitted to the next generation. From the study of gene function to the production of therapeutic humanized antibodies, knock-in mice have a wide range of applications. Genome editing in mice initially relied on random integration of target vectors in embryonic stem cells, and then injection of target clones into donor mouse blastocysts. Later, engineered nucleases were developed to make genome editing more precise. Typical engineered nucleases include ZFN, TALEN and CRISPR. All three nucleases can induce double-strand breaks in the genome. Then, the repair pathway in the cell will be activated, which will eventually lead to knockout of the NHEJ gene or when the donor DNA is present, it is a knock-in mouse for HDR. As a state-of-the-art technology, CRISPR/Cas9 has become the main method for generating genome-edited mice. The CRISPR/Cas9 genome
23-01-2021  |  009x  |  Industry news
Development Base and Future Trends of RNA Drug Research
RNA used to be considered just a molecule that passed information between genes and proteins. In fact, at the beginning of life, RNA is the only living molecule, which can store information and also has the function of an enzyme. It took millions of years of evolution and evolution to produce DNA and protein molecules. In addition to acting as a messenger (mRNA) for protein synthesis, RNA also has a very important regulatory function, such as non-transcribed RNA includes miRNA, siRNA, lncRNA, piwiRNA, etc. Among them, there are more than 400 miRNA molecules alone, regulating at least one-third of human genes. Since the discovery of the DNA double helix structure, scientists began research on the realization of "programmed" pharmaceuticals based on the genetic information contained in nucleic acids and the base-pairing law. The earliest beginning of RNA drug research includes antisense nucleic acid (ASO), small interfering nucleic acid (siRNA), aptamer, aptamer, snRNA,
23-01-2021  |  007x  |  Industry news
Culture Process and Applications of Human Alveolar Epithelial Type II
Type II alveolar epithelial cells (AT2) play a key role in maintaining the integrity and function of the alveoli. Until recently, the role of damage to the epithelial repair mechanism after injury in the pathogenesis of idiopathic pulmonary fibrosis has been confirmed, and AT2 cells have been transferred to the focus of attention. Therefore, it has become necessary to use primary human AT2 cells instead of cell lines for in vitro experiments. Alveolar epithelial cells include two types of special epithelial cells, namely alveolar epithelial type I cells (AT1), which cover about 93% of the alveolar surface area and conduct gas exchange through them, and type II alveolar epithelial cells (AT2) that constitute alveolar cells 60%, and is a producer of different surface active proteins. AT2 cells play a key role in maintaining the integrity and function of the alveoli and serve as AT1 cell progenitors. The damage to the lungs of substances such as cigarette smoke, viruses
22-01-2021  |  014x  |  Industry news
The Cryo-EM Structure of Glucocorticoids
The team of Xu Huaqiang, a researcher at the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences, the team of Jinpeng Sun, a professor of Shandong University, and the team of Professor Zhang Yan of Zhejiang University, have analyzed the cryo-EM structure of glucocorticoid and its membrane receptor GPR97 and Go protein complex for the first time. The first resolved high-resolution structure of adhesion-like GPCRs with ligands and G protein complexes, related research results are published on Nature. Adhesion G protein-coupled receptors (aGPCRs) are members of the GPCR superfamily. They play key molecular switches in some important physiological processes of the organism, such as brain development and water and salt regulation, inflammation and cell fate determination. Compared with other members of the GPCR superfamily, in addition to the classic 7-pass transmembrane core (7TM), aGPCRs also have a longer extracellular region, which constitutes a domain
22-01-2021  |  015x  |  Industry news
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