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Larotrectinib, First TRK Inhibitor Approved by the FDA for Solid Tumors
Larotrectinib, First TRK Inhibitor Approved by the FDA for Solid Tumors
Larotrectinib approved for solid tumors with NTRK MUTATION On November 26, 2018, the US Food and Drug Administration (FDA) approved larotrectinib (Vitrakvi; Loxo Oncology), the first drug approved for the treatment of adults and pediatric patients with solid tumors that have an NTRK gene fusion without a known acquired resistance mutation, are metastatic or where surgical resection is likely to result in severe morbidity, and have no satisfactory alternative treatments or that have progressed after treatment. Larotrectinib received accelerated approval based on overall response rate and duration of response data. Further clinical trials are required to confirm the clinical benefit of larotrectinib. Commenting on this approval, FDA Commissioner Scott Gottlieb, MD, said, “Today’s approval marks another step in an important shift toward treating cancers based on their tumor genetics rather than their site of origin in the body.” Mechanism of action Larotrectinib is
17-09-2020  |  007x  |  Industry news  | 
ADCs Effectively Targets Surface Protein Of Neuroblastoma In Children
ADCs Effectively Targets Surface Protein Of Neuroblastoma In Children
Physician-scientists in the Cancer Center at Children`s Hospital of Philadelphia (CHOP) have developed a preclinical, potent therapy attached to an antibody that targets a surface protein expressed in most childhood neuroblastomas, effectively killing cancer cells. The researchers published their findings in Science Translational Medicine on Mar. 14, 2019. Antibody-drug conjugates or ADCs are a class of biopharmaceutical drugs designed as a targeted therapy for treating cancer. Unlike chemotherapy, ADCs are intended to target and kill tumor cells while sparing healthy cells. "If there is an ultimate `bad guy` of neuroblastoma cell surface proteins--present on most tumors, but not on healthy tissues, and also vulnerable to immunotherapeutic targeting--this just may be it," said study leader Yael Mossé, MD, a pediatric oncologist and researcher at Children`s Hospital of Philadelphia (CHOP). "In 2008, we discovered mutations in the anaplastic lymphoma kinase (ALK) gene
16-09-2020  |  024x  |  Industry news  | 
CPhI Annual Report 2020 Part 1: 2025 will see cell and gene therapy capacit
Continuous Bioprocessing growing quickly, but from a low base, with virtually all manufacturers now using at l Amsterdam, 16 September 2020: CPhI Annual Report – launched ahead of the first CPhI Festival of Pharma (5-16 October, 2020), the world’s largest digital pharma Expo – predicts dramatic growth of new mAb production in China, capacity shortages for cell and gene therapies in the USA, and the widespread global adoption of single-use technologies, but only limited continuous bioprocessing. Three CPhI experts from BioPlan Associates – Vicky Qing XIA, Leo Cai Yang and Eric Langer – explore the rapidly changing global biologics markets, with special reference to the implications for contract outsourcing and China’s continued emergence as a hub for both bio innovation and contract services. Remarkably, China is predicted to continue its rapid bio growth rates, with more than 10 new mAbs predicted to be launched per year in the country by 2025. In fact, the total market size will quadruple by 2025, reaching 120bn RMB, and rising further to 190bn RMB by 2030. “As most
16-09-2020  |  015x  |  Industry news
Probiotics for Industrial and Scientific Research Use
Probiotics for Industrial and Scientific Research Use
Creative Enzymes, a professional and experienced supplier of probiotics, mainly provides enzyme-related products and services. With the continuous expansion of business areas and scale, they have set foot in other areas and established a sound probiotic production and supply chain. Based on high-quality products and services, as well as the unique advantages of large-scale production, its probiotic products are widely favored by industrial customers and scientific research customers. Favorable effects caused by probiotics have been being revealed since the discovery of probiotics. The market of probiotics is rapidly growing due to the increasing demands from the public who are paying more attention to fitness and wellness. A report claims about 1.6 percent of US adults have experience of using probiotics products in the past 30 years. Probiotics are even ranked third in most commonly used dietary supplements other than vitamins and minerals. “Creative Enzymes has a
15-09-2020  |  037x  |  Industry news  | 
Customized Antimicrobial Functional Materials Suitable for Wide Application
Customized Antimicrobial Functional Materials Suitable for Wide Application
For a long time, harmful bacteria have caused great harm to people`s production and life. For example, pathogenic Escherichia coli O157:H7, mad cow disease, foot-and-mouth disease, anthracnose, etc. have caused shocking infections and lead to worries about deterioration of ecological and microbial environment. So countries around the world pay more attention to the research of antibacterial agents. Antibacterial materials are emerging international functional materials in the 1990s. They can provide other materials and products the function of inhibiting and killing microorganisms, and have become an emerging industry worldwide. Creative Diagnostics has long been a leading provider of various kinds of magnetic particles, nanoparticles, quantum dots, beads based kits and devices, etc., now it has expanded the product array to customized antimicrobial functional materials, mainly including: ·Antimicrobial Nanopowder Nano-silver based antimicrobial additives, guanidine-containing
15-09-2020  |  023x  |  Product news  | 
Do I need an Indigo transmitter or just an Indigo probe? Vaisala Indigo family is a modular solution with interchangeable probes, smart transmitters&Indigo Insight.
Do I need an Indigo transmitter or just an Indigo probe?
Vaisala Indigo family is a modular solution with interchangeable probes, smart transmitters&Indigo Insight. The Vaisala Indigo family is a modular solution with interchangeable probes, smart transmitters, and Indigo Insight PC software. There are many probe options to choose from measuring several parameters: humidity, temperature, dew point, carbon dioxide, moisture in oil, and vaporized hydrogen peroxide. The probes can be attached to three different transmitters: the Indigo 201, Indigo 202, and Indigo 520. But when is a probe sufficient on its own – and when do you need both a probe and a transmitter? Indigo-compatible smart probes are based on our well established technology and include everything required to perform measurements – the probes are actually already transmitters. The Indigo-probes have been designed to take users into consideration. Small details are important, for example, standardized cables and an indicator light in the sensor body that shows if the probe is powered. The light also indicates if the communication link is working. When it starts blinking,
15-09-2020  |  082x  |  Product description  | 
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