Development Base and Future Trends of RNA Drug Research
RNA used to be considered just a molecule that passed information between genes and proteins. In fact, at the beginning of life, RNA is the only living molecule, which can store information and also has the function of an enzyme. It took millions of years of evolution and evolution to produce DNA and protein molecules. In addition to acting as a messenger (mRNA) for protein synthesis, RNA also has a very important regulatory function, such as non-transcribed RNA includes miRNA, siRNA, lncRNA, piwiRNA, etc. Among them, there are more than 400 miRNA molecules alone, regulating at least one-third of human genes. Since the discovery of the DNA double helix structure, scientists began research on the realization of "programmed" pharmaceuticals based on the genetic information contained in nucleic acids and the base-pairing law.
The earliest beginning of RNA drug research includes antisense nucleic acid (ASO), small interfering nucleic acid (siRNA), aptamer, aptamer, snRNA,